Biodegradable and Bioabsorbable Materials for Osteosynthesis Applications: State‐of‐the‐Art and Future Perspectives

Cifuentes, Sandra C.; Benavente, Rosario; Lieblich, Marcela; González-Carrasco, José Luis

doi:10.1002/9781119441632.ch88

Cited by 11 publications

(8 citation statements)

References 178 publications

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“…The choice of the bioresorbable material is one of the crucial factors for the design of novel bone implants. The latter must fulfil additional requirements compared to permanent implants available on the market, e.g., to be metabolized by the human body without leaving any trace and gradually lose their mechanical strength during the healing process until bone regeneration [ 1 ]. More particularly, they must be designed to degrade at a rate that will slowly transfer load from the implant to the healing bone [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

et al. 2021

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The present work highlights the crucial role of the interfacial compatibilization on the design of polylactic acid (PLA)/Magnesium (Mg) composites for bone regeneration applications. In this regard, an amphiphilic poly(ethylene oxide-b-L,L-lactide) diblock copolymer with predefined composition was synthesised and used as a new interface to provide physical interactions between the metallic filler and the biopolymer matrix. This strategy allowed (i) overcoming the PLA/Mg interfacial adhesion weakness and (ii) modulating the composite hydrophilicity, bioactivity and biological behaviour. First, a full study of the influence of the copolymer incorporation on the morphological, wettability, thermal, thermo-mechanical and mechanical properties of PLA/Mg was investigated. Subsequently, the bioactivity was assessed during an in vitro degradation in simulated body fluid (SBF). Finally, biological studies with stem cells were carried out. The results showed an increase of the interfacial adhesion by the formation of a new interphase between the hydrophobic PLA matrix and the hydrophilic Mg filler. This interface stabilization was confirmed by a decrease in the damping factor (tanδ) following the copolymer addition. The latter also proves the beneficial effect of the composite hydrophilicity by selective surface localization of the hydrophilic PEO leading to a significant increase in the protein adsorption. Furthermore, hydroxyapatite was formed in bulk after 8 weeks of immersion in the SBF, suggesting that the bioactivity will be noticeably improved by the addition of the diblock copolymer. This ceramic could react as a natural bonding junction between the designed implant and the fractured bone during osteoregeneration. On the other hand, a slight decrease of the composite mechanical performances was noted.

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Section: Introductionmentioning

confidence: 99%

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

et al. 2021

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“…In this context, Magnesium metal, with natural biodegradability properties, has been incorporated into biodegradable polymeric matrices, such as PLA (polylactic acid), as a new strategy to both improve the mechanical properties of the polymer and to control the degradation rate of Mg [5; 6]. With regards to the neat polymer, Mg enhances its mechanical properties, particularly the creep strength [7] and biocompatibility [8]. Mg regulates the mesenchymal stem cell (MSC) behaviour at the interface and the inflammatory response mediated by macrophages and also enhances the osteogenic commitment, as assayed by evaluation of the alkaline phosphatase [9].…”

Section: Introductionmentioning

confidence: 99%

Impact of PLA/Mg films degradation on surface physical properties and biofilm survival

Fernández-Calderón

Romero-Guzmán

Ferrández-Montero

et al. 2020

Colloids and Surfaces B: Biointerfaces

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“…An osteoconductive material is a material able to serve as a scaffold onto which bone cells, such as osteoblasts and osteoclasts, can attach, migrate, grow and/or divide [ 217 ]. The main properties of biodegradable materials for osteosynthesis are excellent mechanical properties, control over degradation time, and biocompatibility [ 218 ]. Generally, membranes for osteosynthesis are made of biopolymers from natural sources, such as collagen, chitosan and cellulose, and synthetic sources, such as expanded polytetrafluoroethylene (e-PTFE), poly lactic acid (PLA), and polycaprolactone (PCL) [ 219 , 220 , 221 ].…”

Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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Biodegradable and Bioabsorbable Materials for Osteosynthesis Applications: State‐of‐the‐Art and Future Perspectives

Cited by 11 publications

References 178 publications

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

Impact of PLA/Mg films degradation on surface physical properties and biofilm survival

Polymeric Membranes for Biomedical Applications

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