Biodegradable and injectable cure-on-demand polyurethane scaffolds for regeneration of articular cartilage

In vitroinvestigations of a novel wound dressing concept based on biodegradable polyurethane

“…The evaluated scaffolds are soft wound surface adaptable and can be simply cut with knives or scissors in any desired shape before application. Injectable PUR scaffolds offer more flexibility in terms of tissue repair [27, 28] and better adaptability to the wound bed in the case of the skin [29]. However, it can be expected that access to the foam-shaped scaffolds described herein from the tissue side is improved due to the high porosity with defined partially interconnected pores, which are shape stable for several days.…”

Anti-Inflammatory Strategies in Cartilage Repair

“…Of the synthetic polymers, those derived from poly(a-hydroxy esters), 136 poly(propylene fumarates), 137 polyurethanes, 138 PGA, 139 and poly(lactideco-glycolide) 140 have been used for cartilage regeneration; however, inflammatory reaction due to synthetic scaffolds that impaired the quality of regenerated cartilage has also been reported in some studies. 141,142 Natural matrix scaffolds Naturally occurring polymers as scaffolds offer options for cartilage tissue engineering due to biocompatibility, biodegradability, low toxicity of degradation by-products, and plasticity in processing into a variety of material formats.…”

Gamma ray-induced synthesis of hyaluronic acid/chondroitin sulfate-based hydrogels for biomedical applications

“…The enzymatic degradation of the hydrogels was determined by monitoring the mass loss of the hydrogels as a function of the time they were exposed to an enzyme solution (Kim and Healy, 2003;Sun et al, 2013;Werkmeister et al, 2010). Each HA/ CS/PAAc hydrogel sample (dimensions ¼ 2.0 Â 5.0 Â 5.0 mm 3 ) was immersed in PBS (pH 7.4) in a shaking water bath at 37 1C.…”