Gamma ray-induced synthesis of hyaluronic acid/chondroitin sulfate-based hydrogels for biomedical applications

Zhao, Linlin; Gwon, Hui-Jeong; Lim, Youn-Mook; Nho, Young Chang; Kim, So Yeon

doi:10.1016/j.radphyschem.2014.08.018

Cited by 18 publications

(8 citation statements)

References 41 publications

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“…This negatively charged glycosaminoglycan usually forms surface layers via electrostatic interactions with other natural or synthetic polymers. Moreover, CS could be modified with additional moieties, such as polylactide (123), acetyl groups (124), methacrylate (125)(126)(127) or fucose sugar (128), to form self-assembled carriers and enhance their drug loading capacity (129).…”

Section: Preparation Methods Of Chondroitin Sulfate-based Systemsmentioning

confidence: 99%

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

Martı́nez

Benito²,

Pérez³

et al. 2016

CPD

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Cancer has become one of the main causes of death in developed countries, and it is expected to be declared as the disease with the highest worldwide morbidity and mortality indexes in the coming decades. Nanomedicine aims to overcome some problems related to this prevalent disease, particularly the lack of efficient diagnostic and therapeutic tools. The most recent scientific advances, which have conducted to a more personalized medicine, were focused on the production of nanocarriers involved into the transport and the delivery of drugs to targeted cells. A wide variety of nanocarriers composed by different materials have been designed for their use as drug delivery systems. Polysaccharides have emerged as very useful biopolymers among all raw materials used in the preparation of these nanoplatforms. They are highly stable, non-toxic and biodegradable molecules, and also present some chemical properties which are very difficult to reproduce using artificial polymers. Anionic polymers, such as hyaluronic acid, heparin or alginate, present some structural and chemical characteristics which make them ideal polymers to prepare nanosystems with anticancer applications. This review will focus on the description of some anionic polysaccharides and the possibilities they offer towards the preparation of nanosystems with applications in cancer treatment and diagnostics.

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Section: Preparation Methods Of Chondroitin Sulfate-based Systemsmentioning

confidence: 99%

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

Martı́nez

Benito²,

Pérez³

et al. 2016

CPD

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“…This research shows how important radiation is in changing the structure and swelling properties of hydrogels, providing useful information about how these materials evolve and behave. In order to achieve a biocompatible matrix suitable for skin tissue engineering, gamma ray irradiation was used to create HA/chondroitin sulfate/polyacrylic acid hydrogel systems without needing additional initiating or crosslinking agents [52]. The production involved gamma ray exposure to facilitate free-radical copolymerization and the crosslinking of the glycosaminoglycans HA, CS, and the synthetic ionic polymer PAAc (as presented in Figure 2).…”

Section: Gamma Radiation-induced Hydrogel Synthesismentioning

confidence: 99%

A Comprehensive Review of Radiation-Induced Hydrogels: Synthesis, Properties, and Multidimensional Applications

Ahmed,

Islam,

Hasan

et al. 2024

Gels

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At the forefront of advanced material technology, radiation-induced hydrogels present a promising avenue for innovation across various sectors, utilizing gamma radiation, electron beam radiation, and UV radiation. Through the unique synthesis process involving radiation exposure, these hydrogels exhibit exceptional properties that make them highly versatile and valuable for a multitude of applications. This paper focuses on the intricacies of the synthesis methods employed in creating these radiation-induced hydrogels, shedding light on their structural characteristics and functional benefits. In particular, the paper analyzes the diverse utility of these hydrogels in biomedicine and agriculture, showcasing their potential for applications such as targeted drug delivery, injury recovery, and even environmental engineering solutions. By analyzing current research trends and highlighting potential future directions, this review aims to underscore the transformative impact that radiation-induced hydrogels could have on various industries and the advancement of biomedical and agricultural practices.

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“…另外, 由于AgNPs在伤口敷料中具有抗炎杀菌的作用, Alcântara等 [46] 通过辐射法制备了两种含有AgNPs的水凝胶(PVP/AgNPs和PVA/ AgNPs), 在辐照过程中, Ag + 还原形成纳米粒子, 图 13 豆苗在不含SAH水凝胶(a)及含SAH水凝胶(b)情况下的生长情况 [11] (网络版彩图) Figure 13 The growth of bean seedlings without SAH hydrogel (a) and with SAH hydrogel (b) [11] (color online). [59] 、人造皮肤 [60,61] 、生物分子、细胞的固定图 14 聚(NVP-co-AAP)水凝胶作为指关节(a)、手腕(b)、腿和脚(c)的固定支撑材料 [23] (网络版彩图) 图 15 Li 2 SO 4 -AG/PAM 双网络水凝胶的辐射合成及在超级电容器中的应用 [65] (网络版彩图) Figure 15 Radiation synthesis process of the Li 2 SO 4 -AG/PAM double network hydrogel electrolytes and its application in supercapacitors [65] (color online).…”

Section: 体自由基进一步与聚合物及纳米基材发生接枝共聚反应而形成水凝胶水溶液体系中水辐解生成的•Oh、unclassified

Research progress of radiation synthesis and application of hydrogels

Shi¹,

Lin²,

Peng³

et al. 2020

Sci. Sin.-Chim

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Gamma ray-induced synthesis of hyaluronic acid/chondroitin sulfate-based hydrogels for biomedical applications

Cited by 18 publications

References 41 publications

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications

A Comprehensive Review of Radiation-Induced Hydrogels: Synthesis, Properties, and Multidimensional Applications

Research progress of radiation synthesis and application of hydrogels

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