Biodegradable bioelectronics for biomedical applications

Lee, Seunghyeon; Silva, Saimon Moraes; Aguilar, Lilith M Caballero; Eom, Taesik; Shim, Bong Sup

doi:10.1039/d2tb01475k

Cited by 12 publications

(6 citation statements)

References 170 publications

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“…Lastly, although this review pertains to implantable devices with extended lifetimes, it is worth noting recent interest in biodegradable substrates, which may be used to safely implement transient bioelectronics when permanent functionality is not required [174][175][176][177][178][179]. Similarly, though not yet meeting standards of high longevity, interest has been shown in the incorporation of 3D printing techniques into device fabrication, which may enable rapid development of customizable devices [180,181].…”

Section: Emerging Substrate Materials and Architecturesmentioning

confidence: 99%

Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations

Niemiec,

Kim

2023

Prog. Biomed. Eng.

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While the importance of thin form factor and mechanical tissue biocompatibility has been made clear for next generation bioelectronic implants, material systems meeting these criteria still have not demonstrated sufficient long-term durability. This review provides an update on the materials used in modern bioelectronic implants as substrates and protective encapsulations, with a particular focus on flexible and conformable devices. We review how thin film encapsulations are known to fail due to mechanical stresses and environmental surroundings under processing and operating conditions. This information is then reflected in recommending state-of-the-art encapsulation strategies for designing mechanically reliable thin film bioelectronic interfaces. Finally, we assess the methods used to evaluate novel bioelectronic implant devices and the current state of their longevity based on encapsulation and substrate materials. We also provide insights for future testing to engineer long-lived bioelectronic implants more effectively and to make implantable bioelectronics a viable option for chronic diseases in accordance with each patient’s therapeutical timescale.

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Section: Emerging Substrate Materials and Architecturesmentioning

confidence: 99%

Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations

Niemiec,

Kim

2023

Prog. Biomed. Eng.

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“…Transient electronics is an emerging field, with metal-, Si-, and organic-(semi)conductors-based electronics transience being demonstrated. 414 Organic conductors, especially conducting polymers, are particularly advantageous as they could be molecularly engineered for on-demand degradation under certain conditions or stimulations. 415 In the long term, fully noninvasive recording of deep physiological activities using wearable electronics is a goal.…”

Section: Future Prospectsmentioning

confidence: 99%

“…Transient devices need to be designed such that the device will only degrade after the predetermined lifetime of operation. Transient electronics is an emerging field, with metal-, Si-, and organic-(semi)conductors-based electronics transience being demonstrated . Organic conductors, especially conducting polymers, are particularly advantageous as they could be molecularly engineered for on-demand degradation under certain conditions or stimulations …”

Section: Summary and Future Prospectsmentioning

confidence: 99%

Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials

Zhang,

Zhu,

et al. 2023

Chem. Rev.

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Bioelectronic devices are designed to translate biological information into electrical signals and vice versa, thereby bridging the gap between the living biological world and electronic systems. Among different types of bioelectronics devices, wearable and implantable biosensors are particularly important as they offer access to the physiological and biochemical activities of tissues and organs, which is significant in diagnosing and researching various medical conditions. Organic conducting and semiconducting materials, including conducting polymers (CPs) and graphene and carbon nanotubes (CNTs), are some of the most promising candidates for wearable and implantable biosensors. Their unique electrical, electrochemical, and mechanical properties bring new possibilities to bioelectronics that could not be realized by utilizing metals-or silicon-based analogues. The use of organic-and carbon-based conductors in the development of wearable and implantable biosensors has emerged as a rapidly growing research field, with remarkable progress being made in recent years. The use of such materials addresses the issue of mismatched properties between biological tissues and electronic devices, as well as the improvement in the accuracy and fidelity of the transferred information. In this review, we highlight the most recent advances in this field and provide insights into organic and carbon-based (semi)conducting materials' properties and relate these to their applications in wearable/implantable biosensors. We also provide a perspective on the promising potential and exciting future developments of wearable/implantable biosensors.

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Section: Introductionmentioning

confidence: 99%

“…Such devices, that can be safely absorbed by the body after they have completed their therapeutic or diagnostic functions (transient bioelectronics), become appealing for medical applications as they eliminate the risks related to surgical retrieval and reduce the chronic foreign body reaction. 2,[5][6][7] Among materials used to establish electronic communication, conducting polymers (CPs) have become a popular choice due to their mixed ionic and electronic conductivity. 3,8,9 This indeed gives them the ability to convert ionic signals, typical of the biological world, to electronic signals, unlike inorganic materials, which are not permeable to ions.…”

Section: Introductionmentioning

confidence: 99%

A cross-linkable and resorbable PEDOT-based ink using a hyaluronic acid derivative as dopant for flexible bioelectronic devices

et al. 2023

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Biodegradable bioelectronics for biomedical applications

Abstract: Biodegradable polymers have been widely used in tissue engineering with the potential to be replaced by regenerative tissue. While conventional bionic interfaces are designed to be implanted in living tissue...

Cited by 12 publications

References 170 publications

Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations

Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations

Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials

A cross-linkable and resorbable PEDOT-based ink using a hyaluronic acid derivative as dopant for flexible bioelectronic devices

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