Biodegradable block copolymers

Kumar, Neeraj; Ravikumar, Majeti N. V.; Domb, Abraham J.

doi:10.1016/s0169-409x(01)00219-8

Cited by 277 publications

(171 citation statements)

References 111 publications

Supporting

Mentioning

168

Contrasting

Unclassified

Order By: Relevance

“…Biodegradable microspheres have been extensively used in pharmaceutical industry because of its advantages of protecting stability, controlled release, decreasing toxicity, and improving biological half time for bioactive agents [7,8]. Biodegradable polymers were the key factor for preparation of biodegradable microspheres, among which, synthetic biodegradable polymers occupy predominant roles and their applications have been dramatically expanded in the past decades [9].…”

Section: Introductionmentioning

confidence: 99%

Soluble starch–based biodegradable and microporous microspheres as potential adsorbent for stabilization and controlled release of coix seed oil

Peng

Xiong

Wang

et al. 2011

Eur Food Res Technol

View full text Add to dashboard Cite

Soluble starch-based biodegradable and microporous microspheres (SDM-Ms) were prepared by emulsion chemical cross-linking technique using trisodium trimetaphosphate (TSTP) as the cross-linker. The resultant amorphous SDM-Ms were excellently identified by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The internal rupture and surface-controlled erosion were the predominant degradation mechanisms for SDM-Ms. The obtained SDM-Ms were applied to adsorb coix seed oil (CSO) by immersing method. The adsorption capacity of CSO within SDM-Ms was determined, namely 0.5238 g/g, and the thermal stability was shown higher than that of the free CSO. A burst release appeared in the second hour, followed by controlled release. Diffusion, degradation, and erosion mechanisms might coexist for the full release processes. The soluble starch (Ss) was demonstrated a promising biodegradable polymer for preparing the porous microspheres. Meanwhile, after being adsorbed into the SDM-Ms, the CSO can be powerfully applied in food and pharmaceutical industries.

show abstract

Section: Introductionmentioning

confidence: 99%

Soluble starch–based biodegradable and microporous microspheres as potential adsorbent for stabilization and controlled release of coix seed oil

Peng

Xiong

Wang

et al. 2011

Eur Food Res Technol

View full text Add to dashboard Cite

show abstract

“…Poly(ethylene-covinyl acetate) and poly(oxyethylene-b-oxypropylene-b-oxyethylene) are block copolymers which have numerous and recognised applications in the development of CDDSs mainly because of their biocompatibility, processability (e.g. extrusion) and proved long-term release properties [22][23][24][25][26].…”

mentioning

confidence: 99%

Supercritical solvent impregnation of poly(ɛ-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(ɛ-caprolactone)/poly(ethylene-vinyl acetate) blends for controlled release applications

Natu

Gil

Sousa

2008

The Journal of Supercritical Fluids

View full text Add to dashboard Cite

Please cite this article as: M.V. Natu, M.H. Gil, H.C. de Sousa, Supercritical Solvent Impregnation of Poly( -caprolactone/poly(oxyethylene-b-oxypropylene-boxyethylene) and Poly( -caprolactone/poly(ethylene-vinyl acetate) Blends for Controlled Release Applications, The Journal of Supercritical Fluids (2007Fluids ( ), doi:10.1016Fluids ( /j.supflu.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractPoly(ε-caprolactone) blends were successfully impregnated with timolol maleate, an antiglaucoma drug, using a Supercritical Solvent Impregnation (SSI) technique. Supercritical fluid impregnation efficiency results suggested that the best impregnating conditions were obtained when a cosolvent was used and when specific drug-polymer interactions occurred as a consequence of different chemical structures due to polymer blending. Pressure can be either a favourable factor, when there is enough drug affinity for the polymers, or an unfavourable factor when weaker bonding is involved. In order to determine the relative * ManuscriptPage 2 of 40 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 hydrophilicity/hydrophobicity of the blends, contact angle analysis was performed, while crystallinity determination was also useful to understand the obtained release profiles.Drug loading, heterogeneous/homogeneous dispersion of drug inside the matrix, hydrophilicity, crystallinity, all seem to influence the obtained drug release rates. The "in vitro" release results suggested that a sustained drug release rate can be obtained by changing the SSI operational conditions and by modulating the composition of blends, as a mean to control crystallinity, hydrophilicity and drug affinity for the polymer matrix. After a first day burst release, all samples showed a sustained release profile (1.2-4 µg/ml/day, corresponding to a mass of 3-10 µg/day) which is between the therapeutic and toxic levels of timolol maleate, during a period of 1 month. These drug-loaded polymeric matrices can be a feasible alternative treatment modality for the conventional repeated daily administration of eye drops.

show abstract

“…Therefore, the outer hydrophilic corona can be functionalized with several moieties, such as folate, monoclonal antibodies, monosaccharides (mannose, glucose, fructose), among others (Torchilin 2001, 2002, Zhang et al 2014. When the PMs have reached their targets and for the release of the drugs, degradable or stimuli-responsive micelles have been developed (Katayama et al 2001, Kumar et al 2001, Neradovic et al 2001, Kakizawa et al 1999. The role of polymeric micelles to improve the efficiency of several PS in PDT treatment is shown in some recent works that will be discussed below.…”

Section: Polymeric Micellesmentioning

confidence: 99%

An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

Mesquita

Dias

Gamelas

et al. 2018

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.

show abstract

Biodegradable block copolymers

Cited by 277 publications

References 111 publications

Soluble starch–based biodegradable and microporous microspheres as potential adsorbent for stabilization and controlled release of coix seed oil

Soluble starch–based biodegradable and microporous microspheres as potential adsorbent for stabilization and controlled release of coix seed oil

Supercritical solvent impregnation of poly(ɛ-caprolactone)/poly(oxyethylene-b-oxypropylene-b-oxyethylene) and poly(ɛ-caprolactone)/poly(ethylene-vinyl acetate) blends for controlled release applications

An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

Contact Info

Product

Resources

About