Biodegradable composite scaffolds of poly(lactic‐co‐glycolic acid) 85:15 and nano‐hydroxyapatite with acidic microclimate controlling additive

Abstract

The aim of this study was to prepare and characterize biodegradable scaffolds of poly(lactic-co-glycolic acid) (PLGA 85:15) and nano-hydroxyapatite (HA) containing magnesium carbonate (MC) as acidic microclimate controlling additive. Porous and nonporous scaffolds of PLGA 85:15 and nano-HA containing MC were prepared by solvent casting and particulate leaching method. Scaffolds were degraded at pH 7.4 phosphate buffer for 90 days. At regular intervals, pH of the degradation medium, release of degradation products, mass loss, water sorption, and tensile strength were measured. The results showed that the pH of the degradation medium significantly decreased with control specimens, whereas the scaffolds with MC did not show significant changes. In addition, acidic monomer release from the scaffolds with MC was found to be less, whereas the water sorption was found to be significantly higher. The tensile strength of the scaffold was found to be dependent on the concentration of HA and porosity. These results indicate that incorpora-

Effect of PLGA Concentration in Electrospinning Solution on Biocompatibility, Morphology and Mechanical Properties of Nonwoven Scaffolds

“…PLGA scaffolds with high molecular weight and amorphous structure could be excellent carriers for drug delivery and provide long-term release of one to six months [48]. The LA/GA monomer ratio used here (85/15) is very common for PLGA scaffolds and has been shown to be effective for the regeneration of nerves [68], bone [69,70] and soft tissue [71,72].…”

Polymer-based porous microcarriers as cell delivery systems for applications in bone and cartilage tissue engineering

“…Therefore, cell and tissue compatibility of poly(alpha hydroxy acid)-based cell seeded microcarriers is limited by inflammatory responses in the body. In order to overcome this side effect and repair defective tissue, poly(alpha hydroxy acids) are often combined with other basic biomaterials (such as type II collagen and bioceramics of tricalcium phosphate and HA powders) to create a neutral microenvironment [175][176][177][178][179]. In addition, biocompatibility and biological performance of poly(alpha hydroxy acid)-based cell-seeded microcarriers can be further enhanced by modifying the microcarrier surface with bioactive moieties such as peptides and proteins [83,152].…”