Biodegradable Electrosprayed NPs as Drug Carriers for Optimal Treatment of Orthopaedic Infections

Electrohydrodynamic atomisation driven design and engineering of opportunistic particulate systems for applications in drug delivery, therapeutics and pharmaceutics

“…A subsequent sustained release pattern is also important, as often the administration of high doses of antimicrobial agents is required in the infected area over a period of 6 -8 weeks. Emerging research following this study could focus on exploiting these electrosprayed nanoparticles for use in cytotoxicity studies as well as researching their interactions with different cell types such as mesenchymal stem cells or bone marrow stromal cells [213].…”

Silver-loaded poly(vinyl alcohol)/polycaprolactone polymer scaffold as a biocompatible antibacterial system

“…Electrospinning enables the production of fibers from a wide range of polymers 19,20 or polymers blends with antibacterial agents 1,5 while allowing control over the properties of the nanofiber mat, such as the fiber's size distribution, porosity, or mat thickness 19 . The main advantages of using electro-spraying in medicine include producing bioactive agents such as NPs 21 and droplets, which act as drug carriers 4,22,23 . Encapsulation, documented in scientific literature, involves a straightforward droplet preparation process: (1) homogeneously dissolve bio-agents in a polymer solution through stirring or ultrasonication, followed by easy electro-spraying, or (2) allow bio-agents to interact with droplets in the particle collection bath, facilitating cross-linking and the formation of new bonds 4,23 .…”