Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Abstract

Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.

The effect of foaming process with supercritical CO2 on the morphology and properties of 3D porous polylactic acid scaffolds

“…After the stress plateau and the significant decrease in the dimensions of the porous structures, there is a transition zone that indicates the beginning of the permanent plastic deformation due to cell collapse by elastic buckling, plastic yielding, or brittle crushing. [ 51 ] Significant change in the dimensions of the samples occurs as a result of densification of the porous material, [ 27 ] which may be associated with the densification of their internal structure, accompanied by the disappearance of the pores and this compacted form offers a higher stiffness to the scaffold. In the final part of the stress–strain curve, the modulus increases with the increase of strain.…”

“…At this critical point, the elastic deformation was ended due to local irreversible deformations such as microbuckling of the struts constructing pore structures. [ 51 ]…”

“…[ 49 ] The stress–strain curves present the same behavior as that of a bone, which presents both fragile and flexible properties during mechanical testing. [ 51 ] When the load is applied, a fragile material responds linearly and fails or breaks before experiencing any permanent deformation. [ 42 ] A flexible material will get into the plastic deformation area and will be considerably deformed before failure or break.…”

A Bibliometric Analysis of Electrospun Nanofibers for Dentistry

“…Besides, the trauma and tumor resection can also lead to the defects of periodontal tissues [ 79 , 80 ]. Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are the two effective methods of regenerating periodontal tissues [ 81 , 82 ]. Most of the membrane made of natural or synthetic polymer has good biocompatibility, biodegradability, osteoconduction, and osteoinductivity.…”

State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applications

“…Importantly, a variety of biodegradable polymers with excellent biocompatibility and that originate from both natural and synthesized sources have been successfully processed into electrospun nanofibers, including silk fibroin (SF), collagen, gelatin, polydioxanone (PPDO), polycaprolactone (PCL), polyglycolide (PGA), poly(L-lactic acid) (PLLA), poly(lactic-co-glycolic acid) (PLGA), poly(L-lactide-co-ε-caprolactone) (PLCL), etc. [ 31 , 32 ]. In addition, various drugs and bioactive ingredients can be easily encapsulated into the nanofibers through the electrospinning technique, which can impart nanofibers with predetermined biological behaviors [ 33 , 34 ].…”