Biodegradable hybrid polymeric membranes for ocular drug delivery

Jain, Dharmendra; Carvalho, Edmund; Banerjee, Rinti

doi:10.1016/j.actbio.2009.11.001

Cited by 67 publications

(35 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 PVA is used in 15 several ocular related applications. 48 Additionally it is the only strictly neutral commercial lens material (many lenses are based on hydroxyethyl methacrylate (HEMA) which although nominally neutral is known to disproportionate, yielding tracial methacrylic acid residues). In this set of experiments the range of dye structures has been extended to cover compounds shown in Table 1, in which modification of the same underlying ring structure produces an extended range of logP and logD values.…”

Section: Kinetics Of Release Into Sink Conditionsmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

View full text Add to dashboard Cite

The poor retention and efficacy of instilled drops as a means of delivering drugs to the ophthalmic environment is well-recognised. The potential value of contact lenses as a means of ophthalmic drug delivery and consequent improvement of pre-corneal retention is one obvious route to the development of a more effective ocular delivery system. Furthermore, the increasing availability and clinical use of daily disposable contact lenses provides the platform for the development of viable single-day use drug delivery devices based on existing materials and lenses. In order to provide a basis for the effective design of such devices, a systematic understanding of the factors affecting the interaction of individual drugs with the lens matrix is required. Because a large number of potential structural variables are involved it is necessary to achieve some rationalisation of the parameters and physicochemical properties (such as molecular weight, charge, partition coefficients) that influence drug interactions. Ophthalmic dyes and structurally related compounds based on the same core structure were used to investigate these various factors and the way in which they can be used in concert to design effective release systems for structurally different drugs. Initial studies of passive diffusional release form a necessary precursor to the investigation of the features of the ocular environment that over-ride this simple behaviour. Commercially available contact lenses of differing structural classifications were used to study factors affecting the uptake of the surrogate actives and their release under "passive" conditions. The interaction between active and lens material shows considerable and complex structure dependence which is not simply related to equilibrium water content (EWC). The structure of the polymer matrix itself was found to have the dominant controlling influence on active uptake; hydrophobic interaction with the ophthalmic dye playing a major role.3

show abstract

Section: Kinetics Of Release Into Sink Conditionsmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

View full text Add to dashboard Cite

show abstract

“…25 Ocular changes were scored for signs of lachrymation, irritation, erythema, edema, and any other ocular reactions until the end of the study. 26 After these examinations, the rabbits were euthanized, and their cornea, conjunctiva, and iris were removed and fixed in 4% formaldehyde, followed by the preparation of histological sections for viewing.…”

Section: Draize Testmentioning

confidence: 99%

Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions

Zhang¹,

Li²,

Ye³

et al. 2014

IJN

View full text Add to dashboard Cite

This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from −7.46 mV to +13.60 mV, by uniformly forming a spherical coating outside the NLC surface, as shown by transmission electron microscopy images. The EDU RS 100 on the NLC surface effectively improved the NLC stability by inhibiting particle size growth. The obtained EDU RS 100-GEN-NLC showed extended precorneal clearance and a 1.22-fold increase in AUC (area under the curve) compared with the bare NLC in a Gamma scintigraphic evaluation. The EDU RS 100 modification also significantly increased corneal penetration producing a 3.3-fold increase in apparent permeability coefficients (P app ) compared with references. Draize and cytotoxicity testing confirmed that the developed EDU RS 100-GEN-NLC was nonirritant to ocular tissues and nontoxic to corneal cells. These results indicate that the NLC surface modified by EDU RS 100 significantly improves the NLC properties and exhibits many advantages for ocular use.

show abstract

“…Solvent cast composite ocular inserts combining polyvinylalcohol and sodium carboxymethylcellulose have been reported for ocular delivery of ciprofloxacillin for topical infections using a rabbit model [92]. In this study, esterification of the polymers was confirmed by Fourier transform infra-red spectroscopy while surface smoothness of 7.3nm was obtained.…”

Section: Ocular Inserts (Films)mentioning

confidence: 59%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

View full text Add to dashboard Cite

There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

show abstract

Biodegradable hybrid polymeric membranes for ocular drug delivery

Cited by 67 publications

References 44 publications

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Contact Info

Product

Resources

About