Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives

Pitarresi, Giovanna; Palumbo, Fabio Salvatore; Giammona, Gaetano; Casadei, Maria Antonietta; Moracci, Franco Micheletti

doi:10.1016/s0142-9612(03)00332-6

Cited by 61 publications

(27 citation statements)

References 29 publications

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“…For this reason, we started our investigation with a set of experiences of photo-cross-linking reactions carried out on 7% solutions of DEX-MA with DD = 14 in these solvents to verify if the hydrogel formation occurred. These conditions of concentration and DD value, already used in other studies (Pitarresi et al 2003), assured a good yield for reactions carried out in water. The yields of the hydrogels, after exhaustive dialysis and freeze-drying, are reported in Table 1.…”

Section: Resultsmentioning

confidence: 66%

“…The methacrylic groups (λ max for DEX-MA in water = 288 nm) are reactive enough to give rise, without initiators, to the network formation in aqueous solutions of the polymer at an opportune concentration (Pitarresi et al 2001(Pitarresi et al , 2003. Compared with other methods, this procedure allows the use of the hydrogels without purification processes that are necessary to remove solvents, catalysts, or initiators usually employed in the other syntheses.…”

Section: Resultsmentioning

confidence: 99%

“…Dextran methacrylate (DEX-MA) was synthesized as already reported (Pitarresi et al 2003). To a solution of dextran (5.0 g) in DMSO (40 ml), DMAP (1.0 g) and GMA (0.73 g, 1 mol/6 mol of repetitive unit) were added.…”

Section: Synthesis Of Dex-mamentioning

confidence: 99%

“…The functionalization of dextran (DEX) with glycidyl methacrylate leads to the formation of a derivative (DEX-MA) that generates hydrogels for ultraviolet (UV) irradiation (Pitarresi et al 2003). 2-phenylpropionic acid, chosen as model of the NSAIDs, was derivatized by reaction with 2-hydroxyethyl methacrylate.…”

Section: Introductionmentioning

confidence: 99%

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Hydrogels of Dextran Containing Nonsteroidal Anti-Inflammatory Drugs as Pendant Agents

et al. 2007

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The oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal tract side effects. To reduce these effects and improve the therapeutic efficacy, NSAIDs are often formulated as controlled release systems. We have prepared a new formulation consisting of dextran hydrogels containing NSAIDs as pendant agents, through ultraviolet irradiation of solutions of dextran functionalized with methacrylic groups in the presence of the drug derivatized in the same way. Release studies of different drugs from this system, carried out in media simulating the gastrointestinal tract, have demonstrated that the amount of released drug is strictly related to the concentration of the polymer in the solution submitted to irradiation as well as to its derivatization degree. Our obtained data confirm that the system is able to realize a colon-specific drug delivery.

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Section: Resultsmentioning

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Section: Synthesis Of Dex-mamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hydrogels of Dextran Containing Nonsteroidal Anti-Inflammatory Drugs as Pendant Agents

et al. 2007

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“…PVA and several polysaccharides have been modified with acrylates and methacrylates by different ways [17][18][19][20]. The addition of unsaturations to polymers allows the reticulation of modified polymers without the addition of cross-linking agents [21][22][23][24][25][26]. The reaction may be carried out through the radical initiator pathway or by UV-light [27].…”

mentioning

confidence: 99%

Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization

Crispim¹,

Piai²,

Fajardo³

et al. 2012

Express Polym. Lett.

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This work reports the preparation of hydrogels based on PVA-GMA, PVA-GMA is poly(vinyl alcohol) (PVA) functionalized with vinyl groups from glycidyl methacrylate (GMA), and on PVA-GMA with different content of chondroitin sulfate (CS). The degrees of swelling of PVA-GMA and PVA-GMA/CS hydrogels were evaluated in distilled water and the swelling kinetics was performed in simulated gastric and intestinal fluids (SGF and SIF). PVA-GMA and PVAGMA/CS hydrogels demonstrated to be resistant on SGF and SIF fluids. The elastic modulus, E, of swollen-hydrogels were determined through compressive tests and, according to the obtained results, the hydrogels presented good mechanical properties. At last, the presence of CS enhances the hydrogel cell compatibility as gathered by cytotoxicity assays. It was concluded that the hydrogels prepared through this work presented characteristics that allow them to be used as biomaterial, as a carrier in drug delivery system or to act as scaffolds in tissue engineering as well

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UV‐Photocrosslinking of Inulin Derivatives to Produce Hydrogels for Drug Delivery Application

Tripodo

Pitarresi

Palumbo

et al. 2005

Macromolecular Bioscience

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In this work, INU, a natural polysaccharide, has been chemically modified in order to obtain new photocrosslinkable derivatives. To reach this goal, INU has been derivatized with MA thus obtaining four samples (INU-MA derivatives) as a function of the temperature and time of reaction. An aqueous solution of the derivative INU-MA1 was irradiated by using a UV lamp with an emission range from 250 to 364 nm and without using photoinitiators. The obtained hydrogel showed a remarkable water affinity but it underwent a partial degradation in simulated gastric fluid. To overcome this drawback, INU-MA1 was derivatized with SA thus obtaining the INU-MA1-SA derivative designed to produce a hydrogel showing a low swelling and an increased chemical stability in acidic medium. Ibuprofen, as a model drug, was loaded by soaking into INU-MA1 and INU-MA1-SA hydrogels and its release from these matrices was evaluated in simulated gastrointestinal fluids. INU-MA1 hydrogel showed the ability to quickly release the entrapped drug thus indicating its potential as a matrix for an oral formulation. INU-MA1-SA hydrogel showed a pH-responsive drug delivery. Therefore it is a promising candidate for controlled drug release in the intestinal tract.

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Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives

Cited by 61 publications

References 29 publications

Hydrogels of Dextran Containing Nonsteroidal Anti-Inflammatory Drugs as Pendant Agents

Hydrogels of Dextran Containing Nonsteroidal Anti-Inflammatory Drugs as Pendant Agents

Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization

UV‐Photocrosslinking of Inulin Derivatives to Produce Hydrogels for Drug Delivery Application

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