Biodegradable Implantable Sensors: Materials Design, Fabrication, and Applications

Ashammakhi, Nureddin; Hernández, Ana López; Unluturk, Bige D.; Quintero, Sergio; Barros, Natan Roberto de; Apu, Ehsanul Hoque; Shams, Abdullah Bin; Ostrovidov, Serge; Li, Jinxing; Contag, Christopher H.; Gomes, Antoinette S.; Holgado, Miguel

doi:10.1002/adfm.202104149

Cited by 73 publications

(71 citation statements)

References 194 publications

(245 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, biofluids (sweat, tears, saliva, and interstitial fluid (ISF)) and exhaled breath play a very important role in wearable device–based biosensing application as all of those can be readily sampled without disrupting the outermost protecting layers of the body’s skin (the stratum corneum). Besides, exhaled breath has also received much attention in the past decade as it contains thousands of components which arise from the lungs, nasal cavities, and have systemic origins in blood [ 5 , 9 – 11 ]. Moreover, implantable devices also attract considerable interest in the recent past.…”

Section: Introductionmentioning

confidence: 99%

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

et al. 2022

View full text Add to dashboard Cite

Given the huge economic burden caused by chronic and acute diseases on human beings, it is an urgent requirement of a cost-effective diagnosis and monitoring process to treat and cure the disease in their preliminary stage to avoid severe complications. Wearable biosensors have been developed by using numerous materials for non-invasive, wireless, and consistent human health monitoring. Graphene, a 2D nanomaterial, has received considerable attention for the development of wearable biosensors due to its outstanding physical, chemical, and structural properties. Moreover, the extremely flexible, foldable, and biocompatible nature of graphene provide a wide scope for developing wearable biosensor devices. Therefore, graphene and its derivatives could be trending materials to fabricate wearable biosensor devices for remote human health management in the near future. Various biofluids and exhaled breath contain many relevant biomarkers which can be exploited by wearable biosensors non-invasively to identify diseases. In this article, we have discussed various methodologies and strategies for synthesizing and pattering graphene. Furthermore, general sensing mechanism of biosensors, and graphene-based biosensing devices for tear, sweat, interstitial fluid (ISF), saliva, and exhaled breath have also been explored and discussed thoroughly. Finally, current challenges and future prospective of graphene-based wearable biosensors have been evaluated with conclusion. Graphical abstract Graphene is a promising 2D material for the development of wearable sensors. Various biofluids (sweat, tears, saliva and ISF) and exhaled breath contains many relevant biomarkers which facilitate in identify diseases. Biosensor is made up of biological recognition element such as enzyme, antibody, nucleic acid, hormone, organelle, or complete cell and physical (transducer, amplifier), provide fast response without causing organ harm.

show abstract

Section: Introductionmentioning

confidence: 99%

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The recent emergence of biodegradable materials offers an opportunity to transform health technologies by enabling sensors that naturally degrade after usage [31][32][33]. The eco-friendly systems developed from degradable materials could also help mitigate significant environmental problems by reducing electronic or medical waste generated, thus also reducing the carbon footprint [34,35].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Invasion Chemotaxis Platform for 3D Neurovascular Co-Culture

Sokullu

Cücük

Sarabi

et al. 2022

Fluids

View full text Add to dashboard Cite

Advances in microfabrication and biomaterials have enabled the development of microfluidic chips for studying tissue and organ models. While these platforms have been developed primarily for modeling human diseases, they are also used to uncover cellular and molecular mechanisms through in vitro studies, especially in the neurovascular system, where physiological mechanisms and three-dimensional (3D) architecture are difficult to reconstruct via conventional assays. An extracellular matrix (ECM) model with a stable structure possessing the ability to mimic the natural extracellular environment of the cell efficiently is useful for tissue engineering applications. Conventionally used techniques for this purpose, for example, Matrigels, have drawbacks of owning complex fabrication procedures, in some cases not efficient enough in terms of functionality and expenses. Here, we proposed a fabrication protocol for a GelMA hydrogel, which has shown structural stability and the ability to imitate the natural environment of the cell accurately, inside a microfluidic chip utilizing co-culturing of two human cell lines. The chemical composition of the synthesized GelMA was identified by Fourier transform infrared spectrophotometry (FTIR), its surface morphology was observed by field emission electron microscopy (FESEM), and the structural properties were analyzed by atomic force microscopy (AFM). The swelling behavior of the hydrogel in the microfluidic chip was imaged, and its porosity was examined for 72 h by tracking cell localization using immunofluorescence. GelMA exhibited the desired biomechanical properties, and the viability of cells in both platforms was more than 80% for seven days. Furthermore, GelMA was a viable platform for 3D cell culture studies and was structurally stable over long periods, even when prepared by photopolymerization in a microfluidic platform. This work demonstrated a viable strategy to conduct co-culturing experiments as well as modeling invasion and migration events. This microfluidic assay may have application in drug delivery and dosage optimization studies.

show abstract

“…Due to their unique optical, magnetic, electronic, and chemical properties and capacity for multiplexing, nanoparticles have been useful in diagnostics, drug delivery and biomedical imaging. [1][2][3] NPs have also been used to advance tissue engineering, regenerative medicine, and stem cell biology by developing an effective cell/tissue-biomaterial interface to support biological functions. 1,4,5 In particular, particles with both magnetic and electric properties have attracted specific interest because of the tremendous potential for targeted drug delivery and control of biological functions.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] NPs have also been used to advance tissue engineering, regenerative medicine, and stem cell biology by developing an effective cell/tissue-biomaterial interface to support biological functions. 1,4,5 In particular, particles with both magnetic and electric properties have attracted specific interest because of the tremendous potential for targeted drug delivery and control of biological functions. For example, superparamagnetic iron oxide has been extensively used as a T 2 -weighted magnetic resonance imaging (MRI) contrast agent.…”

Section: Introductionmentioning

confidence: 99%