Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL–PEG–PCL hydrogel. Part 2: Sol–gel–sol transition and drug delivery behavior

Thermosensitive Micelles from PEG-Based Ether-anhydride Triblock Copolymers

“…In situ gel-forming polymers have recently drawn attention as materials for minimally invasive therapy (50). In particular, thermo-gelling biodegradable polymers with a sol-gel transition point between the room temperature and the body temperature are expected to be useful for injectable polymer systems in biomedical applications.…”

Synthesis of amphiphilic [PEO(PCL)2] triarm star-shaped block copolymers: a promising system for in cell delivery

“…It generally varies from 10 to 16 nm with an average size of about 13 nm. In comparison with the linear di-and triblock copolymer counterparts (PEO-b-PCL and PCL-PEO-PCL) [41][42][43] the micelles formed by [PEO(PCL) 2 ] star-shaped block copolymers have a smaller diameter. Undoubtedly, the formation of polymeric micelles of smaller size and lower CMC values is due to the ability of these copolymers (miktoarm star with double solvophobic tails) to form stable micelles of a lower aggregation number [44].…”

Effect of Paclitaxel-loaded Nanoparticles on the Viability of Human Hepatocellular Carcinoma HepG2 Cells

“…Nevertheless, polyoxyethylene castor oil injection presently used in clinic causes many severe adverse reactions, such as hypersensitivity, toxic renal damage, neurovirulence and cardiotoxicity. To solve this problem, nanocarrier is attracted widespread attention (Chao et al, 2007;Gong et al, 2009). In this study, paclitaxel-loaded poly lactid-co-glycolic acid (PLGA) nanoparticles were prepared, and their inhibitory and apoptotic effects on human hepatocellular carcinoma (HCC) HepG2 cells were observed.…”