Biodegradable interbody cages for lumbar spine fusion: Current concepts and future directions

Laubach, Markus; Kobbe, Philipp; Hutmacher, Dietmar W.

doi:10.1016/j.biomaterials.2022.121699

Cited by 39 publications

(29 citation statements)

References 350 publications

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“…On the other hand, there are certain limitations of clinical use of titanium implants in long bone defects in humans. Porous 3D scaffolds fabricated of titanium alloys induce osseointegration but material obstructs radiological control of ingrowth of newly formed bone in early postoperative period and in long-term follow up after surgery in clinics [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a scaffold-guided bone regeneration with use of highly porous biodegradable scaffolds providing long-term mechanical stability has been emerged [ 76 ]. Our earlier morphological studies demonstrated a positive effect of implant hydroxyapatite coating on the reparative bone formation in experimental fractures: porous surfaces contribute to a microvascular development followed by formation of dense trabecular structure on the implant surface without formation of a connective tissue envelope [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

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Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

et al. 2023

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Previously, 3D-printed bone grafts made of titanium alloy with bioactive coating has shown great potential for the restoration of bone defects. Implanted into a medullary canal titanium graft with cellular structure demonstrated stimulation of the reparative osteogenesis and successful osseointegration of the graft into a single bone-implant block. The purpose of this study was to investigate osseointegration of a 3D-printed degradable polymeric implant with cellular structure as preclinical testing of a new technique for bone defect restoration. During an experimental study in sheep, a 20 mm-long segmental tibial defect was filled with an original cylindrical implant with cellular structure made of polycaprolactone coated with hydroxyapatite. X-ray radiographs demonstrated reparative bone regeneration from the periosteum lying on the periphery of cylindrical implant to its center in a week after the surgery. Cellular structure of the implant was fully filled with newly-formed bone tissue on the 4th week after the surgery. The bone tissue regeneration from the proximal and distal bone fragments was evident on 3rd week. This provides insight into the use of bioactive degradable implants for the restoration of segmental bone defects. Degradable implant with bioactive coating implanted into a long bone segmental defect provides stimulation of reparative osteogenesis and osseointegration into the single implant-bone block.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

et al. 2023

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“…[134][135][136] Despite improved surgical methods and PEEK material properties, there remains a postoperative risk of developing pseudoarthrosis and infection. [137] A study of water sorption cages in the posterior lumbar approach reported that it still suffers from a high failure rate of up to 50%. [138] Therefore, although PEEK composites Reproduced under the terms of the CC BY 4.0 license.…”

Section: Interbody Fusion Cagementioning

confidence: 99%

“…[ 134–136 ] Despite improved surgical methods and PEEK material properties, there remains a postoperative risk of developing pseudoarthrosis and infection. [ 137 ] A study of water sorption cages in the posterior lumbar approach reported that it still suffers from a high failure rate of up to 50%. [ 138 ] Therefore, although PEEK composites have enhanced the ability of osseointegration and resistance to infection, the long‐term research on maintaining postoperative stability and better biocompatibility are still required.…”

Section: Biomedical Applications Of Peekmentioning

confidence: 99%

Research and Application of Medical Polyetheretherketone as Bone Repair Material

Zhang

et al. 2023

Macromolecular Bioscience

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Polyetheretherketone (PEEK) can potentially be used for bone repair because its elastic modulus is similar to that of human natural bone and good biocompatibility and chemical stability. However, its hydrophobicity and biological inertness limit its application in the biomedical field. Inspired by the composition, structure, and function of bone tissue, many strategies are proposed to change the structure and functionality of the PEEK surface. In this review, the applications of PEEK in bone repair and the optimization strategy for PEEK's biological activity are reviewed, which provides a direction for the development of multifunctional bone repair materials in the future.

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“…[42,43] It is evident from the literature that PCL has been employed for biological applications both in thin film and micro/nanostructured forms like electrospun (ES) fibers or 3D printed scaffolds. [44][45][46][47][48] While non-patterned thin films are frequently used as coatings on catheters and surgical devices, micro/nanostructuring is deemed to be crucial for modulating the local microenvironment of the implant host matrix to facilitate cell proliferation and tissue regeneration by mimicking the extracellular matrix. [49] The current work, therefore, involves fabricating PCL films and ES fibers that represent non-structured and structured scaffolds, respectively, and conferring them with antimicrobial properties by covalently immobilizing lysozyme onto the surfaces.…”

Section: Introductionmentioning

confidence: 99%

Probing the Effects of Antimicrobial‐Lysozyme Derivatization on Enzymatic Degradation of Poly(ε‐caprolactone) Film and Fiber

Maroju

Ganesan

Dutta

2023

Macromolecular Bioscience

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Surface derivatization is essential for incorporating unique functionalities into biodegradable polymers. Nonetheless, its precise effects on enzymatic biodegradation still lack comprehensive understanding. In this study, a facile solution‐based method is employed to surface derivatize poly(ε‐caprolactone) (PCL) films and electrospun fibers with lysozyme, aiming to impart antimicrobial properties and examine the impact on enzymatic degradation. The derivatized films and fibers have shown high antibacterial efficacy against E. coli and S. aureus. Through gravimetric analysis, it has been observed that the degradation rate experiences a slight decrease upon lysozyme derivatization. However, this reduction is effectively countered by the inclusion of Tween‐20, as affirmed by isothermal titration calorimetry. Comparing films and fibers, the latter undergoes degradation at a more accelerated pace, coupled with a rapid decline in molecular weight. This study provides valuable insights into the factors influencing the degradation of surface‐derivatized biopolymers through electrospinning, offering a simple strategy to mitigate biomaterial‐associated infections.This article is protected by copyright. All rights reserved

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Biodegradable interbody cages for lumbar spine fusion: Current concepts and future directions

Cited by 39 publications

References 350 publications

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study

Research and Application of Medical Polyetheretherketone as Bone Repair Material

Probing the Effects of Antimicrobial‐Lysozyme Derivatization on Enzymatic Degradation of Poly(ε‐caprolactone) Film and Fiber

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