Biodegradable microparticles preparation by double emulsification—Solvent extraction method: A Systematic study

Baena-Aristizábal, Claudia M.; Fessi, Hatem; Elaı̈ssari, Abdelhamid; Mora-Huertas, Claudia Elizabeth

doi:10.1016/j.colsurfa.2015.11.067

Cited by 21 publications

(10 citation statements)

References 51 publications

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“…The size of nanoparticles decreased clearly with the increase in the rate of homogenization, as confirmed by previous studies (Tcholakova et al, 2003;Tan and Nakajima, 2005). The stirring speed is a key factor during the emulsification stage to obtain smaller particle size due the high shear force (Baena-Aristizabal et al, 2016). Tween 80 acted as a stabilizer in the external aqueous phase and the concentration of Tween 80 played an important role in determining the size of the nanoparticles.…”

Section: Particle Size and Zeta Potentialsupporting

confidence: 80%

Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles

Alp¹,

Çırak²,

Demirbilek³

et al. 2017

Turk J Biol

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Folic acid (FA)-functionalized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles were prepared to enhance the delivery efficiency of the anticancer drug etoposide for the clinical treatment of osteosarcoma. PHBV nanoparticles were synthesized by emulsification/solvent evaporation technique and obtained in the size range of 200-250 nm and zeta potential range of -21 and -27 mV. Encapsulation efficiency and in vitro drug release were studied. The cytotoxic, apoptotic, and necrotic effects of PHBV nanoparticles were also investigated using Saos-2 osteosarcoma cells. The results obtained in this study demonstrate that etoposideloaded and FA-functionalized PHBV nanoparticles can be successfully used for targeted treatment of osteosarcoma.

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Section: Particle Size and Zeta Potentialsupporting

confidence: 80%

Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles

Alp¹,

Çırak²,

Demirbilek³

et al. 2017

Turk J Biol

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“…A graph of viscosity ratio of the internal phase to the external phase shows that a minimum viscosity ratio may be required before particle size increases. Results are discussed with respect to effects of viscosity of primary W/O emulsion and polymer solution, as influenced by the solvent uptake by primary W/O emulsion …”

Section: Resultsmentioning

confidence: 99%

“…Solvent evaporation of dichloromethane was faster than that of the others. The ability of the organic solvent to diffuse seems to be a key factor for the possibility of coalescence phenomena during polymer precipitation and particle formation …”

Section: Resultsmentioning

confidence: 99%

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Effect of solvent type on preparation of ethyl cellulose microparticles by solvent evaporation method with double emulsion system using focused beam reflectance measurement

Muhaimin

Bodmeier

2017

Polym. Int

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The purpose of this study was to investigate the effect of solvent type on the solidification rate of ethyl cellulose (EC) microparticles and particle size/distribution of emulsion droplets/hardened microparticles during the solvent evaporation process using focused beam reflectance measurement (FBRM). EC microparticles were prepared with a water-in-oil-in-water solvent evaporation method using various solvents, including dichloromethane, dichloromethane-methanol (1:1), ethyl acetate and chloroform. The particle size/distribution of the emulsion droplets/hardened microparticles was monitored using FBRM. The morphology of EC microparticles was characterized using scanning electron microscopy (SEM). The transformation of the emulsion droplets into solid microparticles for all solvents occurred within the first 10-90 min. The square weighted mean chord length of EC microparticles prepared using chloroform was smallest, but the chord count was not the highest. The chord length distribution (CLD) measured by FBRM showed that a larger mean particle size gave longer CLD and a lower peak of particle number. SEM data revealed that the morphology of microparticles was influenced by the type of solvent. FBRM can be employed for online monitoring of the shift in the microparticle CLD and detect transformation of emulsion droplets into solid microparticles during the solvent evaporation process. The microparticle CLD and transformation process were strongly influenced by solvent type.

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“…Solvent evaporation of dichloromethane is faster than that of ethyl acetate. The ability of the organic solvent to diffuse seems to be a key factor for the possibility of coalescence phenomena during polymer precipitation and particle formation [57]. When the dispersed phase (PLGA in ethyl acetate) is introduced directly into the continuous or aqueous phase, a sudden extraction of a large quantity of ethyl acetate from the dispersed phase leading to precipitation of the polymer as an aggregate [58].…”

Section: Organic Solventmentioning

confidence: 99%

PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery

Butreddy

Gaddam

Kommineni

et al. 2021

IJMS

116

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Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide (PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled drug delivery to reduce dosing frequency and to improve the therapeutic effects. Biopharmaceuticals such as proteins and peptides are encapsulated in the microspheres to increase their bioavailability and provide a long release period (days or months) with constant drug plasma concentration. The biodegradable and biocompatible properties of PLGA/PLA polymers, including but not limited to molecular weight, end group, lactide to glycolide ratio, and minor manufacturing changes, could greatly affect the quality attributes of microsphere formulations such as release profile, size, encapsulation efficiency, and bioactivity of biopharmaceuticals. Besides, the encapsulated proteins/peptides are susceptible to harsh processing conditions associated with microsphere fabrication methods, including exposure to organic solvent, shear stress, and temperature fluctuations. The protein/peptide containing LAI microspheres in clinical use is typically prepared by double emulsion, coacervation, and spray drying techniques. The purpose of this review is to provide an overview of the formulation attributes and conventional manufacturing techniques of LAI microspheres that are currently in clinical use for protein/peptides. Furthermore, the physicochemical characteristics of the microsphere formulations are deliberated.

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Biodegradable microparticles preparation by double emulsification—Solvent extraction method: A Systematic study

Cited by 21 publications

References 51 publications

Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles

Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles

Effect of solvent type on preparation of ethyl cellulose microparticles by solvent evaporation method with double emulsion system using focused beam reflectance measurement

PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery

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