Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles

Alp, Esma; Çırak, Tamer; Demirbilek, Murat; Türk, Mustafa; Güven, Eylem

doi:10.3906/biy-1612-17

Cited by 9 publications

(9 citation statements)

References 25 publications

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“…The prepared microspheres were centrifuged at 3000 rpm for 5 min and the drug concentration in the supernatant was determined by a UV–visible spectrophotometer (Nanodrop1000, Thermo USA) at a wavelength of maximum ( λ max ) 263 nm. Drug EE of microspheres was calculated by the following formula [15]:

E E ()(, %) = \frac{normalTotal normalamount normalof normalSorafenib - normalAmount normalof normalfree normalSorafenib}{normalTotal normalamount normalof normalSorafenib} \times 100.

The release profile of sorafenib from microspheres was examined in PBS solution (pH 7.4) [16]. In brief, 0.25 mg/ml sorafenib was loaded into the prepared microspheres and microsphere‐sorafenib suspension was centrifuged at 3000 rpm for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment

Alpdemir

Vural

Kara

et al. 2020

IET nanobiotechnol.

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E E ()(, %) = \frac{normalTotal normalamount normalof normalSorafenib - normalAmount normalof normalfree normalSorafenib}{normalTotal normalamount normalof normalSorafenib} \times 100.

Section: Methodsmentioning

confidence: 99%

Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment

Alpdemir

Vural

Kara

et al. 2020

IET nanobiotechnol.

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“…Folate, a targeting ligand, was incorporated to facilitate the tumor uptake of nanoparticles. [15] The authors demonstrated the increase in direct antitumor activity of zoledronate by 80 to 85% in vivo, compared to free drug, which could be explained by the improved tumor uptake and the prolonged drug release kinetics. [47] Similarly, an intelligent nano drug delivery system composed of functional graphene oxide conjugated with folic acid, polyethylene glycol, and photosensitizer indocyanine green was developed for the delivery of MutT homolog 1 inhibitor and doxorubicin.…”

Section: Osteoarthritismentioning

confidence: 99%

“…[44] Advances in nanotechnology have led to the development of multifunctional nanomaterials as diagnostic and therapeutic agents which can target bone tumor and deliver drugs and genes selectively to the targeted cells. [15,45] Targeted delivery and controlled release of chemotherapeutic agents by nanocarriers prevent rapid clearance of the drug, prolong blood circulation time, enhance intra-tumoral accumulation, thereby, improving therapeutic efficacy and minimizing side effects. [45] A cisplatin-crosslinked, doxorubicin-loaded hyaluronic acid nanogel was reported for the effective treatment of osteosarcoma.…”

Section: Osteoarthritismentioning

confidence: 99%

“…[14] It has been utilized in a number of novel approaches including tissue engineering for bone regeneration, targeted drug delivery, surface modification of prosthesis and implants, and diagnostics in orthopedics. [15][16][17][18][19] In particular, nanotechnology-based drug delivery systems have influenced many areas of orthopedics. In the current review, we discuss recent advances on nano-based drug delivery systems in the field of orthopedics.…”

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confidence: 99%

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Nanotechnology-based drug delivery systems in orthopedics

Güven

2021

Jt Dis Relat Surg

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Nanotechnology is a multidisciplinary branch of science which involves the manipulation and control of matter at the nanometer scale to produce new structures, materials, and devices. The concept of nanotechnology was first introduced by Richard P. Feynman [1] in 1959. Since then, nanotechnology has become a research area which promises advancements in many aspects of human life, including electronics, agriculture, transportation, food industry, communication, energy, biological sciences, and medicine. Nanomedicine, the application of nanotechnology in the field of medicine, has the potential to make a great impact on human health and has already impacted and reshaped many aspects of clinical practice and research. Nanotechnology-based materials with unique physical, chemical, and biological characteristics offer a variety of new approaches for clinical practices ranging from prevention to treatment and diagnosis of many diseases and conditions. [2][3][4][5] Among all the applications of nanotechnology in medicine, nano-based drugIn recent years, nanotechnology has led to significant scientific and technological advances in diverse fields, specifically within the field of medicine. Owing to the revolutionary implications in drug delivery, nanotechnology-based drug delivery systems have gained an increasing research interest in the current medical field. A variety of nanomaterials with unique physical, chemical and biological properties have been engineered to develop new drug delivery systems for the local, sustained and targeted delivery of drugs with improved therapeutic efficiency and less or no toxicity, representing a very promising approach for the effective management of diseases. The utility of nanotechnology, particularly in the field of orthopedics, is a topic of extensive research. Nanotechnology has a great potential to revolutionize treatment, diagnostics, and research in the field of orthopedics. Nanophase drug delivery has shown great promise in their ability to deliver drugs at nanoscale for a variety of orthopedic applications. In this review, we discuss recent advances in the field of nanostructured drug delivery systems for orthopedic applications.

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“…Accordingly, HV content of PHBV was considered 2% and 8% (33)(34)(35)(36)(37), PEG/PHBV varied in the range of 15-25% (38)(39)(40)(41)(42), and two molecular weights of PEG (MW 3350 and 6000) were used for the study.…”

Section: Preparation and Optimization Of Bz-phbv Implantsmentioning

confidence: 99%

Fabrication, Optimization, and In Vitro and In Vivo Characterization of Intra-vitreal Implant of Budesonide Generally Made of PHBV

et al. 2020

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Drug delivery to vitreous in comparison with drug delivery to the other parts of the eye is complicated and challenging due to the existence of various anatomical and physiological barriers. Developing injectable intra-vitreal implant could be beneficial in this regard. Herein, poly(hydroxybutyrate-co-valerate) (PHBV) implants were fabricated and optimized using response surface method for budesonide (BZ) delivery. The acquired implants were characterized in regard to the stability of the ingredients during fabrication process, drug loading amount, and drug release pattern (in PBS-HA-A and in vitreous medium). According to this research and statistical analysis performed, first HV% (hydroxyvalerate) then molecular weight and ratio of PEG as pore former affect respectively release rate and burst strength of BZ with different coefficients. Drug release profile in rabbit eye correlated well with that of in vitro (R 2 = 0.9861, p 0.0001). No significant changes were seen in ERG waves, intraocular pressure, and histological studies during the in vivo part of the project. Using 8% HV, 20% PEG/PHBV, and higher molecular weight PEG (i.e., 6000), the optimum formulation was achieved. Toxicity and biocompatibility of the optimized formulation, which were evaluated in vivo, indicated the suitability of design implant for intra-vitreal BZ delivery.

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Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles

Cited by 9 publications

References 25 publications

Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment

Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment

Nanotechnology-based drug delivery systems in orthopedics

Fabrication, Optimization, and In Vitro and In Vivo Characterization of Intra-vitreal Implant of Budesonide Generally Made of PHBV

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