Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges

Bonilla, Lorena; Ettcheto, Miren; Espina, Marta; García, María L.; Camins, Antoni; Souto, Eliana B.; Cano, Amanda

doi:10.1002/epi4.12567

Cited by 25 publications

(16 citation statements)

References 62 publications

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“…The surface charge of polymeric nanoparticles can be either positive or negative depending on the polymer composition, which determines their biological characteristics. Bio‐adhesiveness, cell penetration, and muco‐adhesiveness are also based on this feature 25 . PNPs can also be biologically active and transportable, depending on their structure.…”

Section: Synthetic Nano‐delivery Systems For Epilepsymentioning

confidence: 99%

Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives

Movahedpour,

Taghvaeefar,

Asadi‐Pooya

et al. 2023

CNS Neurosci Ther

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Epilepsy is a common chronic neurological disorder caused by aberrant neuronal electrical activity. Antiseizure medications (ASMs) are the first line of treatment for people with epilepsy (PWE). However, their effectiveness may be limited by their inability to cross the blood–brain barrier (BBB), among many other potential underpinnings for drug resistance in epilepsy. Therefore, there is a need to overcome this issue and, hopefully, improve the effectiveness of ASMs. Recently, synthetic nanoparticle‐based drug delivery systems have received attention for improving the effectiveness of ASMs due to their ability to cross the BBB. Furthermore, exosomes have emerged as a promising generation of drug delivery systems because of their potential benefits over synthetic nanoparticles. In this narrative review, we focus on various synthetic nanoparticles that have been studied to deliver ASMs. Furthermore, the benefits and limitations of each nano‐delivery system have been discussed. Finally, we discuss exosomes as potentially promising delivery tools for treating epilepsy.

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Section: Synthetic Nano‐delivery Systems For Epilepsymentioning

confidence: 99%

Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives

Movahedpour,

Taghvaeefar,

Asadi‐Pooya

et al. 2023

CNS Neurosci Ther

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“…In contrast, biodegradable NPs made of biocompatible lipids and polymers can be naturally degraded into non-toxic bioproducts in the human body. Moreover, they can be designed for their degradation only at the target site, remaining stable at off-target regions [ 129 ]. For example, PLA can be hydrolysed into lactic acid under physiological conditions and PLGA into lactic and glycolic acids and, after, being degraded into non-toxic products, such as water and carbon dioxide, that are easily excreted (reviewed in [ 130 ]).…”

Section: Critical Overviewmentioning

confidence: 99%

Fighting Epilepsy with Nanomedicines—Is This the Right Weapon?

et al. 2023

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Epilepsy is a chronic and complex condition and is one of the most common neurological diseases, affecting about 50 million people worldwide. Pharmacological therapy has been, and is likely to remain, the main treatment approach for this disease. Although a large number of new antiseizure drugs (ASDs) has been introduced into the market in the last few years, many patients suffer from uncontrolled seizures, demanding the development of more effective therapies. Nanomedicines have emerged as a promising approach to deliver drugs to the brain, potentiating their therapeutic index. Moreover, nanomedicine has applied the knowledge of nanoscience, not only in disease treatment but also in prevention and diagnosis. In the current review, the general features and therapeutic management of epilepsy will be addressed, as well as the main barriers to overcome to obtain better antiseizure therapies. Furthermore, the role of nanomedicines as a valuable tool to selectively deliver drugs will be discussed, considering the ability of nanocarriers to deal with the less favourable physical-chemical properties of some ASDs, enhance their brain penetration, reduce the adverse effects, and circumvent the concerning drug resistance.

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“…Bonilla et al, (2021) proposed nanoparticles with biodegradable properties for the treatment of epilepsy. 44 These particles have the potential for increased penetration and specific site delivery. In addition, advances are made to improve the effectiveness of nanoparticles.…”

Section: Future Perspective Of Nanobiotechnology In Pharmacology and ...mentioning

confidence: 99%

Past, Present and Future Perspective of Application of Nanobiotechnology in Pharmacology and Innovative Therapeutics

Mweetwa

Mampane

Kenaope

et al. 2022

MRAJ

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Nanobiotechnology is a multi-strategic approach that engineers biological components (atoms and molecules) at the nanoscales. The concept was introduced as an effective alternative with drug delivery and targeting properties. Nanobiotechnology has several applications in cancerous disease, autoimmune, inflammation, infectious, and viral diseases, and for the management of COVID-19. Nanoparticles have biomimetic properties, encapsulation, and safety formulation of drugs, and all these properties give them an advantage over conventional drug strategies. Nanobiotechnology research is currently progressive and needs extensive exploration and understanding for its potential use in future innovations. The present review studied the concept of nanobiotechnology, its origin, mechanism of drug delivery and targeting, applications, and future perspective in pharmacology and innovation to decipher its role in future advanced research.

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Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 25 publications

References 62 publications

Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives

Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives

Fighting Epilepsy with Nanomedicines—Is This the Right Weapon?

Past, Present and Future Perspective of Application of Nanobiotechnology in Pharmacology and Innovative Therapeutics

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