Biodegradable nanoparticles — From sustained release formulations to improved site specific drug delivery

Leroux, Jean‐Christophe; Allémann, Éric; Jaeghere, Fanny De; Doelker, Éric; Gurny, Robert

doi:10.1016/0168-3659(95)00164-6

Cited by 240 publications

(130 citation statements)

References 36 publications

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“…For degradable polymers, two different erosion mechanisms were proposed: homogeneous or bulk erosion and heterogeneous or surface erosion [79] (Figure 19). PLA and their copolymers in the form of nano-particles were used in the encapsulation process of many drugs, such as psychotic [80], restenosis [81], hormones [82], oridonin [83], dermatotherapy [84], and protein (BSA) [85]. Different methods were used to obtain these nano-particles, such as solvent evaporation, solvent displacement [86], salting out [80], and emulsion solvent diffusion [87].…”

Section: Drug Delivery Systemmentioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

602

306

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Abstract. Polylactic acid (PLA), one of the well-known biodegradable polyesters, has been studied extensively for tissue engineering and drug delivery systems, and it was also used widely in human medicine. A new method to synthesize PLA (ring-opening polymerization), which allowed the economical production of a high molecular weight PLA polymer, broadened its applications, and this processing would be a potential substitute for petroleum-based products. This review described the principles of the polymerization reactions of PLA and, then, outlined the various materials properties affecting the performance of PLA polymer, such as rheological, mechanical, thermal, and barrier properties as well as the processing technologies which were used to fabricate products based on PLA. In addition, the biodegradation processes of products which were shaped from PLA were discussed and reviewed. The potential applications of PLA in the medical fields, such as tissue engineering, wound management, drugs delivery, and orthopedic devices, were also highlighted.

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Section: Drug Delivery Systemmentioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

602

306

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“…It was reported that the drug release rate from the larger nanoparticles was slower than the small size nanoparticles. 23 These results suggest that differences in the particle size are a significant factor affecting the drug release rate in the nanoparticle system.…”

Section: Resultsmentioning

confidence: 71%

“…Generally, a surfactant must be used to make small-sized nanoparticles in conventional emulsion solvent evaporation systems 23 and the surfactant used can absorb onto the nanoparticle surface. 4 The absorbed surfactant is known to affect the particle size, the biodegradation rate, the biodistribution, and the physicochemical properties of the nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Testosterone-encapsulated Surfactant-free Nanoparicles of Poly(DL-lactide-co-glycolide): Preparation and Release Behavior

Jeong¹,

Shim²,

Song³

et al. 2002

Bulletin of the Korean Chemical Society

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Since surfactant or emulsifiers remained on the nanoparticle surface significantly affect the physicochemical properties, the biodegradation rate, the biodistribution, and the biocompatibility of nanoparticles, surfactantfree nanoparticles should be good candidate. surfactant-free PLGA nanoparticles were successfully prepared by both the dialysis method and the solvent diffusion method. The PLGA nanoparticles prepared using the solvent diffusion method has a smaller particle size than the dialysis method. The solvent diffusion method was better for a higher loading efficiency than the dialysis method but the nanoparticle yield was lower. Testosterone (TST) release from the PLGA nanoparticles was dependent on the particle size rather than the drug contents. Testosterone release from the PLGA nanoparticles prepared by the solvent diffusion method using acetone was faster than those prepared by the dialysis method. TST release from the PLGA nanoparticles prepared by the solvent diffusion method using acetone and the dialysis method using dimethylformamide (DMF) was completed for 4 days while the PLGA nanoparticles prepared by the dialysis method using acetone showed approximately 80% TST release after 4 days. Since the PLGA nanoparticle degradation ratio was below 20% within 5 days at all samples while TST release completed within 4 days, TST release was dependent on the diffusion mechanism rather than degradation.

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“…The targeting of the immune activating substances by particulate delivery directly to the lymph nodes, where the anticancer immune response is initiated, could help reduce unspecific adverse effects (Kranz et al, 2016). Furthermore, encapsulation in a polymer matrix allows the formulation of poorly hydrophilic drugs as injectable suspensions and may provide a delayed release to avoid tolerance (Leroux et al, 1996;Zeisser-Labouèbe et al, 2006). To date, a limited number of studies have reported the use of nanocarriers in imiquimod or resiquimod delivery for cancer immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulation

Widmer

Thauvin

Mottas

et al. 2018

International Journal of Pharmaceutics

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A B S T R A C TSmall-molecule agonists for the Toll-like receptors (TLR) 7 and 8 are effective for the immunotherapy of skin cancer when used as topical agents. Their systemic use has however been largely unsuccessful due to doselimiting toxicity. We propose a polymer-based nanodelivery system to target resiquimod, a TLR7 ligand, to the lymph node in order to focus the immunostimulatory activity and to prevent a generalized inflammatory response. We demonstrate successful encapsulation of resiquimod in methoxypoly(ethylene glycol)-b-poly(DLlactic acid) (mPEG-PLA) and mixed poly(DL-lactic-co-glycolic acid) (PLGA)/mPEG-PLA nanoparticles. We show that these particles are taken up mainly by dendritic cells and macrophages, which are the prime initiators of anticancer immune responses. Nanoparticles loaded with resiquimod activate these cells, demonstrating the availability of the immune-stimulating cargo. The unloaded particles are non-inflammatory and do not have cytotoxic activity on immune cells. Following subcutaneous injection in mice, mPEG-PLA and PLGA/mPEG-PLA nanoparticles are detected in dendritic cells and macrophages in the draining lymph nodes, demonstrating the targeting potential of these particles. Thus, polymer-based nanoparticles represent a promising delivery system that allows lymph node targeting for small-molecule TLR7 agonists in the context of systemic cancer immunotherapy.

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Biodegradable nanoparticles — From sustained release formulations to improved site specific drug delivery

Cited by 240 publications

References 36 publications

Properties and medical applications of polylactic acid: A review

Properties and medical applications of polylactic acid: A review

Testosterone-encapsulated Surfactant-free Nanoparicles of Poly(DL-lactide-co-glycolide): Preparation and Release Behavior

Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulation

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