Biodegradable poly(ɛ-caprolactone)–poly(ethylene glycol) copolymers as drug delivery system

Synthesis and evaluation of biodegradable PCL/PEG nanoparticles for neuroendocrine tumor targeted delivery of somatostatin analog

“…Approval from the Food and Drug Administration makes PEG as one of the promising polymers, for its systemic consumption, which is widely applied in biomedical fields. PEG polymer can prevent protein absorption and improve the biocompatibility for blood contact compound (Lewis et al, 1990;Wei et al, 2009). In the malignancy of the pancreas surgery, radiation, and chemotherapy are of limited effectiveness, and there is essentiality, in developing new therapies (Von Hoff et al, 1998;Van Cutsem et al, 1995;Greenlee et al, 2000;Gou et al, 2009;Chanana et al, 2009).…”

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

“…Some drug delivery systems that employ a biodegradable polymer, such as nanoparticles delivering anticancer agents, are commercially available. PCL-PEG-PCL copolymers are biodegradable, easy to produce, have an amphiphilic character, and have strong potential application in drug delivery systems (16)(17)(18).…”

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice

“…Controlled drug delivery systems have achieved long-term maintenance of therapeutic drug levels and received increased medical and public acceptance. Biodegradable polymers have been the most attractive merit, because they do not require removal after the drug has been released (Wei et al, 2009). As described previously, the biodegradable fiber implants have been developed for the favorable release profile.…”