Biodegradable poly(polyol sebacate) polymers

Bruggeman, Joost P.; Bruin, Berend-Jan de; Bettinger, Christopher J.; Langer, Robert

doi:10.1016/j.biomaterials.2008.08.037

Cited by 208 publications

(265 citation statements)

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“…26 Since PGS was rstly reported, several other polyols have been polymerized with sebacic acid to cover a wide range of mechanical properties and expand the spectrum of biomedical applications for these materials. 16,27,30 The most attractive synthetic feature of PPS is that through altering the stoichiometry of the diacid and polyol as well as varying the polycondensation conditions, the mechanical properties and degradation rates can be easily tuned. Moreover, PPS have biodegradability under physiological conditions and acceptable biocompatibility comparable to PLGA, 16,31 and they have been reported as non-toxic based on in vitro 32 and in vivo studies.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] To overcome these shortcomings, the development of novel biodegradable polyester elastomers, which are able to control their elastic properties and exibility to better match with the elastic nature, biocompatibility and degradation prole of so tissues, has increased considerably. 16,17 Several researchers have synthesized polyester elastomers based on polyols such as 1,8-octanediol, ethylene glycol, butylene glycol, castor oil or glycerol, and carboxylic acids such as citric acid, ricinoleic acid, and sebacic acid, [18][19][20][21][22][23][24][25] which nd application in so-tissue engineering as nerve-guidance, drug delivery, tissue adhesives and scaffolds to repair or replace body tissues. [1][2][3][4]19,26,27 Poly(glycerol sebacate) (PGS) represents the most studied member of the poly-polyol sebacate (PPS) family, all of which are attractive because they are inexpensive and endogenous monomers found in human metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

et al. 2015

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A., 2008, 105, 2307). However, PPS generally display poor mechanical properties, in particular a low modulus, that limit the true potential of these materials in the biomedical field. Here, we introduce an approach to obtain nanocomposites based on poly(mannitol sebacate) (PMS) matrices reinforced with cellulose nanocrystals (CNCs) in order to improve the application range of these materials. Different strategies were used based on varying the feed ratios between mannitol : sebacic acid (1 : 1 and 1 : 2), crosslinking conditions and CNCs content, resulting in different degrees of crosslinking and, therefore, mechanical and degradation behavior. All of the developed nanocomposites displayed the expected mass loss during the degradation studies in simulated body fluid (SBF) similar to the neat matrix, however, doubling the sebacic acid feed ratio or extending the curing temperature and time, resulted in higher mechanical properties, structural integrity, and shape stability during a degradation time lessening mass loss rate. Changing mannitol : sebacic acid reaction ratios from 1 : 1 to 1 : 2 and for low crosslinking degree neat samples, the Young's modulus increases four-fold, while mass loss after 150 days of incubation is reduced by half. The Young's modulus range obtained with this process covers the range of human elastic soft tissues to tough tissues (0.7-200 MPa). IntroductionIn the past few years, there has been steady progress in the development of biodegradable polymers for application in the medical eld because these materials provide new opportunities to design less invasive and resorbable implants, tissue scaffolds, and medical devices that are able to avoid second revision surgeries, that limit the risk of infection and results in less trauma for the patient.5-8 Moreover, biodegradable polymeric systems which offer the possibility to tailor their mechanical properties from so to stiffer as well as the biodegradability ratio by varying the processing conditions also have additional advantages. Medical devices based on different classes of biodegradable polymers such as polyesters, polyanhydrides and polyurethanes have been widely investigated and some of them are commercially available as resorbable sutures, drug delivery systems, vascular gras, wafers and orthopaedic xation devices based, among others, on polylactic acid (PLA), polyglycolic acid (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(3-caprolactone) (PCL), poly(p-dioxanone) (PDO), or poly(trimethylene carbonate) (PTMC).9,10 However, most of these polymeric systems have degradation rates that are not optimal for short-medium term applications. For example, it takes more than 24 months for poly(caprolactones) and poly(Llactic acid) to degrade in a biological environment, and from 2 to 24 months, depending on the ratio, for copolymers of polylactic acid (PLA) and polyglycolic acid (PGA). Also, the degradation rate for polyanhydrides is slow, around 12 months. 6,9,11 Moreover, these polymers have a lack of exibility and elasticity at bod...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

et al. 2015

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“…We extended the previous fabrication and characterization of PLGA NGCs by performing direct and indirect contact cytotoxicity tests. Though PLGA is a well-established biomaterial, our use of neuronal cells extends previous studies on fibroblasts, [66][67][68] and is directly relevant to our intended application for neuronal regeneration. For both direct contact and extracts testing, no signs of cytotoxicity were found in terms of cell proliferation and cell viability.…”

Section: Novel Device Features and Characterizationmentioning

confidence: 59%

A Novel Internal Fixator Device for Peripheral Nerve Regeneration

Chuang

Wilson

Love

et al. 2013

Tissue Engineering Part C: Methods

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Recovery from peripheral nerve damage, especially for a transected nerve, is rarely complete, resulting in impaired motor function, sensory loss, and chronic pain with inappropriate autonomic responses that seriously impair quality of life. In consequence, strategies for enhancing peripheral nerve repair are of high clinical importance. Tension is a key determinant of neuronal growth and function. In vitro and in vivo experiments have shown that moderate levels of imposed tension (strain) can encourage axonal outgrowth; however, few strategies of peripheral nerve repair emphasize the mechanical environment of the injured nerve. Toward the development of more effective nerve regeneration strategies, we demonstrate the design, fabrication, and implementation of a novel, modular nerve-lengthening device, which allows the imposition of moderate tensile loads in parallel with existing scaffold-based tissue engineering strategies for nerve repair. This concept would enable nerve regeneration in two superposed regimes of nerve extension-traditional extension through axonal outgrowth into a scaffold and extension in intact regions of the proximal nerve, such as that occurring during growth or limb-lengthening. Self-sizing silicone nerve cuffs were fabricated to grip nerve stumps without slippage, and nerves were deformed by actuating a telescoping internal fixator. Poly(lactic co-glycolic) acid (PLGA) constructs mounted on the telescoping rods were apposed to the nerve stumps to guide axonal outgrowth. Neuronal cells were exposed to PLGA using direct contact and extract methods, and they exhibited no signs of cytotoxic effects in terms of cell morphology and viability. We confirmed the feasibility of implanting and actuating our device within a sciatic nerve gap and observed axonal outgrowth following device implantation. The successful fabrication and implementation of our device provides a novel method for examining mechanical influences on nerve regeneration.

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“…The degradation of polyphosphazenes and the linkage of reactive drug molecules to the polymer backbone are controlled by the side-group modification. Langer and coworkers reported a family of synthetic biodegradable Poly (Polyol Sebacate) (PPS) via the bulk polycondensation reactions of the polyol and sebacic acid monomers [20]. Material properties including the physicochemical and mechanical properties as well as the degradation rates of the obtained PPS can be tuned by altering the reacting stoichiometric ratio of monomers polyol and sebacic acid.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

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2015

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The essence of "nano-" science and technology is based on the finding that the properties of materials over the size range of 1-100 nm differ from those of the bulk material. The unique properties of these various types of intentionally produced nanomaterials provide them with novel electrical, catalytic, magnetic, mechanical, thermal, and imaging features that are highly desirable for applications in commercial, medical, military, and environmental sectors. These materials may also find their way into more complex nanostructures and systems. As new uses for materials with these special properties are identified, the number of products containing such nanomaterials and their possible applications continues to grow.In the fields of molecular biology and medicine, cancer has been the leading cause of death and a serious threat to the body health of *Corresponding author: Garry L Rempel, Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada; Tel: +1 5198884567, Extn: 32702; Fax: +1 5197464979; E-mail: grempel@uwaterloo.ca Citation: Wang H, Rempel GL (2015) Introduction of Polymer Nanoparticles for Drug Delivery Applications. J Nanotechnol Nanomed Nanobiotechnol 2: 008. human beings. Until now, the main techniques to fight cancer are non-targeted chemotherapy and radiation. However, it is unavoidable to prevent systematic side effects to the human body due to non-specific uptake by normal, healthy, noncancerous tissues because of the instinctive properties of the chemotherapy chemical agent featured with high toxicity and a lack of tumor specificity.In order to overcome the limitations of free chemotherapeutic agents, targeting of tumors with nanoparticulate drug carriers has received much attention and expectance [1,2]. Nanocarriers can offer many avenues over free drugs for the following aspects [3]: (1) protect the drug from premature degradation; (2) prevent drugs from prematurely interacting with the biological environment; (3) enhance absorption of the drugs into a selected tissue (for example, solid tumour); (4) control the pharmacokinetic and drug distribution profile; and (5) improve intracellular penetration.Let us first recall the important moments in the short but rapid development history of drug delivery systems (Figure 1). Lipid is the first nanotechnology based drug delivery system, which was discovered in the 1960s and later known as liposomes [4]. After that, biomaterials made of a variety of organic and inorganic substances were developed for drug delivery. In 1976, the first controlled release polymer drug delivery system was reported [5]. In 1980, pH stimuli drug delivery systems to trigger drug release [6] and cell specific targeting of liposomes were reported [7,8]. In 1987, the first long circulating liposome named "stealth liposomes" was described [9]. Subsequently, the use of Polyethylene Glycol (PEG) was known to increase circulation times for liposomes [10] and polymer nanoparticles [11] in 1990 and 1994, respe...

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Biodegradable poly(polyol sebacate) polymers

Cited by 208 publications

References 28 publications

Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

A Novel Internal Fixator Device for Peripheral Nerve Regeneration

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