Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect

Abstract

Poly-ε-caprolactone (PCL) is a biodegradable aliphatic polyester that can be used in the field of biomaterials. Electrospinning is the name given to the process of producing micro and nanoscale fibers using electrostatically charged polymeric solutions under certain conditions. Almost all synthetic and naturally occurring polymers can undergo electrospinning using suitable solvents or mixtures prepared in certain proportions. In this study, silica aerogels were obtained by the sol-gel method. PCL-silica aerogel fibers were synthesized by adding 0.5, 1, 2, and 4% ratios in the PCL solution. Blood contact analysis was performed on the produced fibers with UV-VIS. According to the results obtained, 0.5, 1, 2, and 4% nano-silver were added to the fiber-containing 4% aerogel. Then, SEM-EDS and FTIR analyses were performed on all fibers produced. Antimicrobial tests were performed on fibers containing nano-silver. As a result, high-performance blood coagulation fibers were developed using PCL with aerogel, and an antimicrobial effect was achieved with nano-silver particles. It is thought that the designed surface will be preferred in wound dressing and biomaterial in tissue engineering, as it provides a high amount of cell adhesion with a small amount of blood and contains antimicrobial properties.

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

“…This enables one to tailor their properties, such as mechanical strength, porosity, and degradation rate, to specific biomedical applications. However, the method can be complex and may require the optimization of various parameters (e.g., reaction conditions and drying conditions) to achieve the desired scaffold characteristics [ 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. As shown in Figure 1 b, Wei Ma et al used chitosan nanofibers (CSNF), prepared using the pulping homogenization method combined with the sol–gel method, and further introduction of polyvinyl alcohol (PVA), to prepare chitosan nanofiber/nanosilica and chitosan nanofiber/nanosilica/PVA scaffolds [ 24 ].…”

Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene

“…Covalently cross-linked polymers obtained through the Diels-Alder reaction [14], non-covalently cross-linked non-toxic cryogels of chitosan and polyvinyl alcohol [15], gum arabic cryogels [16], nanofibers based on biodegradable poly-ε-caprolactone, and poly-Llactide obtained via centrifugal spinning or electrospinning [17][18][19][20][21] have been used as gels to prepare wound dressings. Hydrogels based on carboxymethyl cellulose [22] and its combination with carbomer 940 [23], carboxymethyl chitosan [24,25], and chitosan with bacterial cellulose [26] are used to treat chronic wounds and burns.…”