Biodegradable polymer brush as nanocoupled interface for improving the durability of polymer coating on metal surface

Bedair, Tarek M.; Cho, Youngjin; Joung, Yoon Ki; Han, Dong Keun

doi:10.1016/j.colsurfb.2014.08.025

Cited by 24 publications

(9 citation statements)

References 41 publications

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“…Also, the blood compatibility test exhibited that the nanocoupled modified sample contains a fewer number of platelet adhered on the surface as compared to the unmodified Co-Cr plate or coated sample. Moreover, the elution of sirolimus from the PLLA brush-modified sample showed a control release (Bedair et al 2014a).…”

Section: Biodegradable Polymer-coated Desmentioning

confidence: 94%

“…In addition, Cho et al (2014) suggested strongly the nanocoupling strategy to address the cracking issue of polymer coating on DES by introducing the RA-PCL brush on the surface of Co-Cr stent (Cho et al 2014). Bedair et al (2014a) also studied the effect of polymer brushes on the durability of the polymer/drug coating. The surface modification steps of Co-Cr were shown in Scheme 7.…”

Section: Biodegradable Polymer-coated Desmentioning

confidence: 99%

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Coating defects in polymer-coated drug-eluting stents

Bedair¹,

Cho²,

Park³

et al. 2014

Biomaterials and Biomedical Engineering

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Vascular stenting has a great attention as a treatment for coronary arteries diseases as compared with percutaneous balloon angioplasty. In-stent restenosis and thrombosis are side effects resulting from using bare metal stent (BMS). Employing platelet therapy allowed to reduce the rate of thrombosis, however, the rate of restenosis remains a major problem. In 2002, drug-eluting stents (DESs) were introduced as an effort to reduce the restenosis. The commercially available DESs continue to suffer from coating defects that might lead to a series of adverse effects. Most importantly, multiple concerns remain regarding the polymer coating integrity on metal surfaces or the relation of polymer irregularities to longterm adverse events.

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Section: Biodegradable Polymer-coated Desmentioning

confidence: 94%

Section: Biodegradable Polymer-coated Desmentioning

confidence: 99%

Coating defects in polymer-coated drug-eluting stents

Bedair¹,

Cho²,

Park³

et al. 2014

Biomaterials and Biomedical Engineering

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“…Recently, our group focused on studies of polymer brushes effects as an interface for the adhesion and durability of a biodegradable polymer for DES [22,23]. According to our previous works, the thickness of 16 nm of PCL-brushes increased the adhesion of the coating to the substrate more effectively than 10 nm [22].…”

Section: Introductionmentioning

confidence: 98%

Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

Bedair

et al. 2015

Journal of Colloid and Interface Science

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“…degradable or non-degradable, and (iii) anti-proliferative drug(s) such as sirolimus (SRL) or paclitaxel. 9,10 Polymer coating for DES is used to control the elution of therapeutic drugs within a period of time. However, many complications are associated with the use of polymers for DES application.…”

Section: Introductionmentioning

confidence: 99%

Sustained drug release using cobalt oxide nanowires for the preparation of polymer-free drug-eluting stents

et al. 2018

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Polymer-based drug-eluting stents (DESs) represented attractive application for the treatment of cardiovascular diseases; however, polymer coating has caused serious adverse responses to tissues such as chronic inflammation due to acidic by-products. Therefore, polymer-free DESs have recently emerged as promising candidates for the treatment; however, burst release of drug(s) from the surface limited its applications. In this study, we focused on delivery of therapeutic drug from polymer-free (or -less) DESs through surface modification using cobalt oxide nanowires (CoO NWs) to improve and control the drug release. The results demonstrated that CoO NWs could be simply fabricated on cobalt-chromium substrate by ammonia-evaporation-induced method. The CoO NWs were uniformly arrayed with diameters of 50-100 nm and lengths of 10 µm. It was found that CoO NWs were comparatively stable without any delamination or change of the morphology under in vitro long-term stability using circulating system. Sirolimus was used as a model drug for studying in vitro release behavior under physiological conditions. The sirolimus release behavior from flat cobalt-chromium showed an initial burst (over 90%) after one day. On the other hand, CoO NWs presented a sustained sirolimus release rate for up to seven days. Similarly, the polymer-less specimens on CoO NWs substrates sustained sirolimus release for a longer-period of time when compared to flat Co-Cr substrates. In summary, the current approach of using CoO NWs-based substrates might have a great potential to sustain drug release for drug-eluting implants and medical devices including stents.

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Biodegradable polymer brush as nanocoupled interface for improving the durability of polymer coating on metal surface

Cited by 24 publications

References 41 publications

Coating defects in polymer-coated drug-eluting stents

Coating defects in polymer-coated drug-eluting stents

Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

Sustained drug release using cobalt oxide nanowires for the preparation of polymer-free drug-eluting stents

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