Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

Bedair, Tarek M.; Yu, Seung Jung; Im, Seyoung; Park, Bang Ju; Joung, Yoon Ki

doi:10.1016/j.jcis.2015.08.051

Cited by 26 publications

(14 citation statements)

References 49 publications

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“…Compared to conventional liquid phase‐based methods, the solvent‐free process can generate polymer coatings of relatively high purity, which is essential for bioengineering, as some residual impurities produce harmful side effects in cells and proteins. In addition, the thin iCVD polymer films remained durable and robust in aqueous conditions (water, buffer, and medium), rendering them suitable for monitoring cellular behaviors or interactions occurring between biomolecules that require monitoring for long periods Such advantageous characteristics of the iCVD process have been exploited for tissue regeneration, thermos‐responsive functionalization for cell sheet engineering, biosensors, and functional coatings for biomedical devices …”

Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

“…a) The thermo‐responsive and anti‐fouling properties of a pNIPAM‐coated titanium implant via iCVD process . b) Schematic illustrations of the iCVD modified Co–Cr alloy surface fabrications and their effect on the stability of the SRL‐in‐PDLLA coating layer . a) reproduced with permission .…”

Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

“…Bedair et al also investigated effects of the wettability and thickness of the interfacial layer on the coating morphology and drug release characteristics of drug‐eluting stents (DESs) (Figure b) . Through piCVD, HEMA imbues the Co‐Cr surface with hydroxyl surface functionality.…”

Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

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Initiated Chemical Vapor Deposition: A Versatile Tool for Various Device Applications

et al. 2017

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Advances in device technology have been accompanied by the development of new types of materials and device fabrication methods. Considering device design, initiated chemical vapor deposition (iCVD) inspires innovation as a platform technology that extends the application range of a material or device. iCVD serves as a versatile tool for surface modification using functional thin film. The building of polymeric thin films from vapor phase monomers is highly desirable for the surface modification of thermally sensitive substrates. The precise control of thin film thicknesses can be achieved using iCVD, creating a conformal coating on nano-, and microstructured substrates such as membranes and microfluidics. iCVD allows for the deposition of polymer thin films of high chemical functionality, and thus, substrate surfaces can be functionalized directly from the iCVD polymer film or can selectively gain functionality through chemical reactions between functional groups on the substrate and other reactive molecules. These beneficial aspects of iCVD can spur breakthroughs in device fabrication based on the deposition of robust and functional polymer thin films. This review describes significant implications of and recent progress made in iCVD-based technologies in three fields: electronic devices, surface engineering, and biomedical applications.

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Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

Section: Icvd For Biomedical Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Initiated Chemical Vapor Deposition: A Versatile Tool for Various Device Applications

et al. 2017

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“… 1 Several studies to optimize the coating conditions 6 and to improve the stability of the drug-in-polymer matrix coating were developed for further enhancing the efficacy of DESs under in vitro as well as in vivo clinical studies. 7 – 11 …”

Section: Introductionmentioning

confidence: 99%

Recent advances to accelerate re-endothelialization for vascular stents

et al. 2017

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Cardiovascular diseases are considered as one of the serious diseases that leads to the death of millions of people all over the world. Stent implantation has been approved as an easy and promising way to treat cardiovascular diseases. However, in-stent restenosis and thrombosis remain serious problems after stent implantation. It was demonstrated in a large body of previously published literature that endothelium impairment represents a major factor for restenosis. This discovery became the driving force for many studies trying to achieve an optimized methodology for accelerated re-endothelialization to prevent restenosis. Thus, in this review, we summarize the different methodologies opted to achieve re-endothelialization, such as, but not limited to, manipulation of surface chemistry and surface topography.

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Synthesis of Poly(2-Hydroxyethyl Methacrylate)-based Hybrid Nanoparticles via Visible-Light-Initiated Radical Polymerization

Wang

et al. 2017

Journal of the Chinese Chemical Society

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We report a new, unique process for the design of poly(2‐hydroxyethyl methacrylate) (PHEMA)‐based hybrid materials, which involves the coating of PHEMA on TiO2 and TiO2 /Ag nanoparticle surface under visible light. New hybrid materials initiated under different conditions were prepared under visible light, which could be used for the theoretical design of nanohybrid materials. The hybrid materials thus prepared were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). The experimental results confirmed the successful synthesis of TiO2–PHEMA hybrid materials. Compared to other methods, the method reported here involving the direct combination of PHEMA on the TiO2 surface was simply catalyzed by visible light without the addition of initiators.

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Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

Cited by 26 publications

References 49 publications

Initiated Chemical Vapor Deposition: A Versatile Tool for Various Device Applications

Initiated Chemical Vapor Deposition: A Versatile Tool for Various Device Applications

Recent advances to accelerate re-endothelialization for vascular stents

Synthesis of Poly(2-Hydroxyethyl Methacrylate)-based Hybrid Nanoparticles via Visible-Light-Initiated Radical Polymerization

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