Biodegradable polymer composites based on synthetic and natural polymers of various classes

Роговина, С. З.

doi:10.1134/s1811238216010100

Cited by 52 publications

(29 citation statements)

References 58 publications

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Section: Introductionmentioning

confidence: 99%

“…The creation of composites of synthetic polymers with polymers produced from the natural raw materials attracts a great interest, since it reduces the dependence on inevitably depleting oil stocks as a source for production of synthetic polymers. 1,2 Among the polymers synthesized from the natural monomers, of particular interest is polylactide (PLA), a linear aliphatic polyester formed at polymerization (polycondensation) of lactic acid, which is a product of the enzymatic fermentation of corn, sugar beet, potato, and so forth. [3][4][5] The PLA has good mechanical properties comparable with the characteristics of the synthetic polymers, it is stable to the action of oil and ultraviolet (UV) radiation, but it demonstrates brittleness and low fracture toughness.…”

Section: Introductionmentioning

confidence: 99%

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Production and investigation of structure and properties of polyethylene–polylactide composites

Роговина

Прут

Aleksanyan

et al. 2019

J of Applied Polymer Sci

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Under conditions of shear deformations, low‐density polyethylene (LDPE) and polylactide (PLA) composites are obtained in rotor disperser. The production of these composites allows one to use polymers derived from natural raw and to reduce the cost of the materials on their base. The addition of rigid PLA leads to increase in elastic modulus from 200 for LDPE to 1190 for LDPE–PLA (50:50 wt %) composites and in tensile strength from 13.3 for LDPE to 17.8 for LDPE–PLA. By differential scanning calorimetry method, it is shown that LDPE and PLA are incompatible. Using X‐ray diffraction analysis, it is found that degree of crystallinity of composites decreases from 46.1 at 50:50 wt % to 36.9 at 80:20 wt % component ratios with the rise in LDPE content. Tests on fungus resistance show that the composites containing 50 wt % PLA are more resistant than the composites containing 30 wt % PLA. First by gel‐permeation chromatography method, it is shown that composite degradation after exposure in soil is accompanied by the PLA chain scission and depolymerization with formation of monomers and dimers (M w of PLA decreases from 118,860 to 80,100). The obtained composites can be applied as packaging materials. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47598.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Production and investigation of structure and properties of polyethylene–polylactide composites

Роговина

Прут

Aleksanyan

et al. 2019

J of Applied Polymer Sci

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“…Currently, a new approach to the development of polymer materials is being formed, consisting in the need to obtain polymers that retain performance only during the consumption period, and then experience the decomposition process under the influence of environmental factors [1][2], This approach should be applied to polymer devices and products, both in electronic and in ordinary household sphere [3 -5]. When processing and operating polymer materials under the influence of environmental factors (ultraviolet radiation, moisture, oxygen, ozone, etc.…”

Section: Introductionmentioning

confidence: 99%

Study of the effect of photooxidative processes on the surface morphology and physico-mechanical characteristics of biodegradable materials based on secondary polypropylene and chalk additives

et al. 2020

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When processing and operating polymer materials under the influence of environmental factors (ultraviolet radiation, moisture, oxygen, ozone, etc.), a change in their properties is often observed. This research is devoted to the study of the effect of chalk additives on morphology and topography, as well as the physical and mechanical properties of samples based on recycled polypropylene raw materials after exposure to UV radiation in air. In order to confirm the occurrence of photo oxidative processes, the data of two methods were used: modified iodometric analysis and IR spectroscopy. The physical and mechanical properties of polymer composites before and after photo aging were determined on standard 1 mm thick blades. To study the surface changes of experimental polymer composites under the influence of ultraviolet radiation, atomic force microscopy was used. The result of the experiment is the proof that the chalk additive interferes with the intensive course of photo-oxidative degradation. In general, the introduction of a chalk additive in a small amount (2 to 10 weight parts) allows maintaining the strength characteristics of composites based on recycled polypropylene raw materials after exposure to UV radiation in air, probably because of crosslinking of macromolecules due to the intermolecular interaction of hydro peroxide groups accumulated by the polymer, as well as involving only surface layers of composite samples in the photo oxidation process. Moreover, the analysis of AFM images of samples subjected to ultraviolet irradiation for 18 hours shows that the surface becomes smoother. This is confirmed by the calculation of the root mean square roughness and the maximum height of the roughness. Further irradiation for additional 18 hours leads to an increase in roughness, which indicates a change in the supra molecular structure in the surface layers of polypropylene as a result of photo oxidative transformations. Therefore, from the obtained composites, one can expect the maintenance of operational characteristics during the period of consumption, followed by decomposition under the influence of environmental factors.

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“…Many strategies involve different forms of immobilization of the drug in microspheres or hydrogels [1][2][3][4][5][6], e.g., through cross-linking of various molecules to generate biodegradable microsphere polymers, which trap the active drug compound. There is a large range of polymers with different biodegradation and drug release profiles [7,8], including both micelles [9], peptide nanorods [10] and composites of polysaccharides and polylactides [11]. Delivery of self-assembled peptides may offer another strategy to generate an injectable drug with extended release.…”

Section: Introductionmentioning

confidence: 99%

Release of Pharmaceutical Peptides in an Aggregated State: Using Fibrillar Polymorphism to Modulate Release Levels

Madsen

Christiansen

Giehm

et al. 2019

Colloids and Interfaces

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Traditional approaches to achieve sustained delivery of pharmaceutical peptides traditionally use co-excipients (e.g., microspheres and hydrogels). Here, we investigate the release of an amyloidogenic glucagon analogue (3474) from an aggregated state and the influence of surfactants on this process. The formulation of peptide 3474 in dodecyl maltoside (DDM), rhamnolipid (RL), and sophorolipid (SL) led to faster fibrillation. When the aggregates were subjected to multiple cycles of release by repeated resuspension in fresh buffer, the kinetics of the release of soluble peptide 3474 from different surfactant aggregates all followed a simple exponential decay fit, with half-lives of 5–18 min and relatively constant levels of release in each cycle. However, different amounts of peptide are released from different aggregates, ranging from 0.015 mg/mL (3475-buffer) up to 0.03 mg/mL (3474-DDM), with 3474-buffer and 3474-RL in between. In addition to higher release levels, 3474-DDM aggregates showed a different amyloid FTIR structure, compared to 3474-RL and 3474-SL aggregates and a faster rate of degradation by proteinase K. This demonstrates that the stability of organized peptide aggregates can be modulated to achieve differences in release of soluble peptides, thus coupling aggregate polymorphism to differential release profiles. We achieved aggregate polymorphism by the addition of different surfactants, but polymorphism may also be reached through other approaches, including different excipients as well as changes in pH and salinity, providing a versatile handle to control release profiles.

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Biodegradable polymer composites based on synthetic and natural polymers of various classes

Cited by 52 publications

References 58 publications

Production and investigation of structure and properties of polyethylene–polylactide composites

Production and investigation of structure and properties of polyethylene–polylactide composites

Study of the effect of photooxidative processes on the surface morphology and physico-mechanical characteristics of biodegradable materials based on secondary polypropylene and chalk additives

Release of Pharmaceutical Peptides in an Aggregated State: Using Fibrillar Polymorphism to Modulate Release Levels

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