Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery

Abstract

Figure 11. Schematic illustration of pullulan conjugated with deoxycholic acid (DOCA) (PUL-DOCA), and PUL-DOCA grafted with N α -Boc-Lhistidine (bHis) (PUL-DOCA-bHis); TEM images of PUL-DOCA-bHis NGs at pH 8.5 (a) and 6.2 (b). Adapted with permission from ref 148.

A redox strategy to tailor the release properties of Fe(III)-alginate aerogels for oral drug delivery

“…The erosion rate of alginate gels can be effectively tuned by the use of redox responsive crosslinking agents (Bawa, Pillay, Choonara, & du Toit, 2009;Li, Maciel, Rodrigues, Shi, & Tomas, 2015). It was shown that chemically crosslinked alginate hydrogels are sensitive for the reduction of the linking disulfide bonds.…”

“…It was shown that chemically crosslinked alginate hydrogels are sensitive for the reduction of the linking disulfide bonds. The degradation of the hydrogel is triggered by a reductive environment, which induces the release of the incorporated active agent (Li et al, 2015;Maciel et al, 2013). Another promising strategy to produce redox responsive hydrogels is to crosslink alginate chains by a redox active metal ion which radically changes its affinity towards alginate when its oxidation state changes.…”

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)&ndash;polyethylene glycol&ndash;folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

“…In the last few decades, rapid development of biodegradable polymeric carriers has attracted considerable attention, because of their versatile functional construction and biocompatibility for wide applications in biomedicine, such as drug delivery, gene delivery, tissue engineering, diagnosis, antibacterial/antifouling properties, and medical devices. [1][2][3][4][5][6][7][8][9] With regard to security, with rational design, biodegradable polymeric carriers are able to degrade into friendly biological catabolites, which is particularly important to reduce systemic cytotoxicity caused by the carrier. On the other hand, simplex biodegradable carriers cannot always meet rigorous demands, owing to the extremely hostile and complex environments in vivo.…”

Preparation of pH-Responsive Poly(aspartic acid) Nanogels in Inverse Emulsion

“…recognition factors) are immobilized onto their surface [5,6]. Well-known approaches for preparing nanogels include photolithographic and micromolding techniques, microfluidics, free radical heterogeneous polymerization in dispersion, nanoprecipitation and emulsion techniques [2,[7][8][9]. Water-in-oil (inverse) emulsion technique is the most widely used since it does not require any complicated equipment and the size of the resultant nanogels can be easily controlled.…”

“…intermolecular disulfide formation by the oxidation of thiol-groups [10]). Several examples are summarized in recent reviews of Matyjaszewski [2], Li [8] and Landfester [11] for the preparation of nanogels in the size range of 100-500 nm by inverse emulsion technique. Recently nanogels have been prepared mostly from natural polymers, e.g.…”