Biodegradable Polymer Scaffolds for Cartilage Tissue Engineering

Lu, Lichun; Zhu, Xun; Valenzuela, Richard G.; Currier, Bradford L.; Yaszemski, Michael J.

doi:10.1097/00003086-200110001-00024

Cited by 204 publications

(135 citation statements)

References 101 publications

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“…Beyond being a simple mechanical substrate, the scaffold interacts with cells, bioactive molecules and mechanical signals in a dynamic and synergistic manner to contribute to the process of regeneration [163]. The main characteristics of an ideal scaffold include sterility, biocompatibility, biodegradability and sufficient mechanical properties to support cell differentiation and matrix production.…”

Section: Scaffoldsmentioning

confidence: 99%

“…The main characteristics of an ideal scaffold include sterility, biocompatibility, biodegradability and sufficient mechanical properties to support cell differentiation and matrix production. Furthermore, the nature and type of defect determining the size and shape of the tissue to be regenerated together with the joint conditions of the patient must be taken into consideration when selecting the appropriate scaffold [163]. Finally, in the case of OA degeneration the choice of scaffold is particularly challenging due to the involvement of other joint tissues, namely synovium and subchondral bone, which are also affected by the disease.…”

Section: Scaffoldsmentioning

confidence: 99%

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Cartilage tissue engineering for degenerative joint disease☆

Nešić

Whiteside

Brittberg

et al. 2006

Advanced Drug Delivery Reviews

210

156

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Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages. Although many, mostly surgical techniques, are currently employed to treat cartilage lesions, none has given satisfactory results in the long term. Recent advances in biology and material science have brought tissue engineering to the forefront of new cartilage repair techniques. The combination of autologous cells, specifically designed scaffolds, bioreactors, mechanical stimulations and growth factors together with the knowledge that underlies the principles of cell biology offers promising avenues for cartilage tissue regeneration. The present review explores basic biology mechanisms for cartilage reconstruction and summarizes the advances in the tissue engineering approaches. Furthermore, the limits of the new methods and their potential application in the osteoarthritic conditions are discussed.

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Section: Scaffoldsmentioning

confidence: 99%

Section: Scaffoldsmentioning

confidence: 99%

Cartilage tissue engineering for degenerative joint disease☆

Nešić

Whiteside

Brittberg

et al. 2006

Advanced Drug Delivery Reviews

210

156

View full text Add to dashboard Cite

show abstract

“…Moreover, there is still immunological concern associated with naturally derived polymers. An additional problem limits the application of the natural polymeric materials scaffolds, there are still a question mark on their structure homogeneity and reproducibility [11,[35][36][37][42][43][44][45][46][47][48]. Metal and polymer drawbacks Bioceramic Scaffolds http://dx.doi.org/10.5772/intechopen.70194mentioned above lead to emerging of a new type of materials prevent the production of the wear debris and can be designed to more closely match the material properties of natural bone.…”

Section: Bioceramic Scaffold Materialsmentioning

confidence: 99%

Bioceramic Scaffolds

Amin¹,

Ewais²

2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Millions of peoples in the world suffer from their bone damage tissues by disease or trauma. Every day, thousands of surgical procedures are performed to replace or repair these tissues. The availability of these tissues is a big problem, and their costs are expensive. The repair of these defects has become a major clinical and socioeconomic need with the increase of aging population and social development. The emerge of tissue engineering (TE) is considered as a glimmer of hope to contribute in solving this problem. It aims at the regeneration of damaged tissues with restoring and maintaining the function of human bone tissues using the combination of cell biology, materials science, and engineering principles. In this chapter, the current state of the tissue engineering in particular bioceramic scaffolds was discussed. Concept of tissue engineering was explored. Bioceramic scaffold materials, their processing techniques, challenges taken into consideration the design of the scaffolds, and their in-vitro and in-vivo studies were highlighted. The scaffolds with extra-functionalities such as drug release ability and clinical applications were mentioned.

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“…Natural polymers that have been explored as bioactive scaffolds for cartilage tissue engineering include alginate, agarose, fibrin, hydroxyapatite (HA) , collagen, gelatin, chitosan, chondroitin sulfate, and cellulose. [11][12][13][14][15][16] Natural polymers can often interact with cells via cell surface receptors to regulate or direct cell functions. However, because of this interaction, these polymers may also stimulate an immune system response; thus, antigenicity and disease transfer are of concern when using these biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Novel nano-rough polymers for cartilage tissue engineering

Balasundaram¹,

Storey²,

Webster³

2014

IJN

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This study presents an innovative method for creating a highly porous surface with nanoscale roughness on biologically relevant polymers, specifically polyurethane (PU) and polycaprolactone (PCL). Nanoembossed polyurethane (NPU) and nanoembossed polycaprolactone (NPCL) were produced by the casting of PU and PCL over a plasma-deposited, spiky nanofeatured crystalline titanium (Ti) surface. The variables used in the process of making the spiky Ti surface can be altered to change the physical properties of the spiky particles, and thus, the cast polymer substrate surface can be altered. The spiky Ti surface is reusable to produce additional nanopolymer castings. In this study, control plain PU and PCL polymers were produced by casting the polymers over a plain Ti surface (without spikes). All polymer surface morphologies were characterized using both scanning electron microscopy and atomic force microscopy, and their surface energies were measured using liquid contact angle measurements. The results revealed that both NPU and NPCL possessed a higher degree of nanometer surface roughness and higher surface energy compared with their respective unaltered polymers. Further, an in vitro study was carried out to determine chondrocyte (cartilage-producing cells) functions on NPU and NPCL compared with on control plain polymers. Results of this study provided evidence of increased chondrocyte numbers on NPU and NPCL compared with their respective plain polymers after periods of up to 7 days. Moreover, the results provide evidence of greater intracellular protein production and collagen secretion by chondrocytes cultured on NPU and NPCL compared with control plain polymers. In summary, the present in vitro results of increased chondrocyte functions on NPU and NPCL suggest these materials may be suitable for numerous polymer-based cartilage tissue-engineering applications and, thus, deserve further investigation.

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Biodegradable Polymer Scaffolds for Cartilage Tissue Engineering

Cited by 204 publications

References 101 publications

Cartilage tissue engineering for degenerative joint disease☆

Cartilage tissue engineering for degenerative joint disease☆

Bioceramic Scaffolds

Novel nano-rough polymers for cartilage tissue engineering

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