Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

Deng, Chao; Jiang, Yanjiao; Cheng, Ru; Meng, Fenghua; Zhong, Zhiyuan

doi:10.1016/j.nantod.2012.08.005

Cited by 540 publications

(399 citation statements)

References 116 publications

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“…11 Functionalization of the outer space of the polymeric nanomicelles to modify its physicochemical or biological properties is of great value from the perspective of design and development of intelligent nano-drug delivery systems, which can be accomplished by constructing micelles with a variety of end-functionalized copolymers. To date, strategic modification of polymeric micelles with functional peptides, saccharides, antibodies, and aptamers on their periphery has been reported, 12,13 with attempt to enhance tumor accumulation, penetration, and retention. The folate receptor, which is expressed normally at the luminal surface of polarized epithelia, 14,15 has been found to be overexpressed in some solid tumors, such as ovarian, endometrial, colorectal, breast, lung, and renal cell carcinoma as well as brain metastases derived from epithelial cancer, and neuroendocrine carcinoma.…”

Section: Introductionmentioning

confidence: 99%

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment

Chen¹,

Zhang²,

Huang³

et al. 2015

IJN

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The therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor-overexpressing tumors treatment was investigated in this study. Due to its high structural similarity to folic acid and the high expression of folate receptor in most solid tumors, MTX serves as not only a cytotoxic agent but also a homing ligand. Cellular uptake and the endocytic mechanism studies of MTX-conjugated mixed micelles were performed in folate receptor-rich KBv and folate receptor-deficient A-549 cancer cells. Additionally, the efficacy and safety studies of F127/P105-MTX in KBv tumor-bearing mice were evaluated. Results indicate that F127/P105-MTX significantly enhanced the cellular uptake in KBv cells as compared to that of conventional non-MTX-conjugated mixed micelles. Moreover, the results showed that F127/P105-MTX can be internalized by both caveolae- and clathrin-mediated endocytosis in energy-dependent and folate receptor-dependent manners. The in vitro and in vivo antitumor efficacies of F127/P105-MTX were significantly enhanced in comparison with MTX-entrapped mixed micelles. Furthermore, no acute toxicities to hematological system and major organs have been observed after intravenous administration during the regimen. Therefore, our results suggest that F127/P105-MTX could be an effective and safe nano-drug delivery system for cancer therapy, especially for the folate receptor-rich cancer treatment.

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Section: Introductionmentioning

confidence: 99%

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment

Chen¹,

Zhang²,

Huang³

et al. 2015

IJN

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“…NPs are synthesized in order to deliver a drug to the right place at the right time in adequate concentration [5][6][7][8]. The proteins are also widely used for encapsulation and transportation of different drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic and kinetic characterization of pH-dependent interactions between bovine serum albumin and ibuprofen in 2D and 3D systems

Csapó

Juhász

Varga

et al. 2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Biodegradable micelles are derived from aliphatic polycarbonates and polyesters, which are the most potent agents for clever and targeted delivery of effective lipophilic antitumor drugs such as paclitaxel (PTX) and doxorubicin (DOX) [39][40][41][42]. However, the therapeutic efficacy of degradable micellar drug formulations remains low due to poor stability in the body, less uptake of cancer cells and slow drug release in cancer cells [43,44]. A high level in vivo stability is essential to avoid the premature medications release, improve cancer targetability and reduce systemic toxicity [45][46][47].…”

Section: Galactose Receptormentioning

confidence: 99%

Liposomes and Nanotechnology in Drug Development: Focus On Pancreatic Cancer

Malik¹,

Jin²,

Raheem³

et al. 2017

JGPLD

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Pancreatic cancer usually has high morbidity and mortality and rests one of the most challenging cancers to treat. 5 years survival rate is less than 6 percent overall for people with pancreatic cancer, because of very late diagnosis and absence of effective treatment. In a western world, pancreatic tumor is the fourth most common cause of death in a western world. The pancreatic tumor needs selective delivery of drugs to target cells, with no side effects is major goals of the recent investigations for the real treatment of the pancreatic tumor. Medication which targets pancreatic tumor cells specially and carriers which deliver medications to specific cells which are quickly dividing, development of these kind drugs is considered as magic for the management of pancreatic cancer. In latest years, liposomes and nanotechnology can show a vital character in the treatment of pancreatic tumor. Liposomes contain multiple characteristics, such as the ability to protect the material from degradation, the capacity for encapsulating many materials and capability for delivering materials intracellularly fusion with plasma membrane. Nanoparticles as a carrier offer a new style of delivery of the medications to target cells of a tumor and allow drugs for the binding to tumor cell membrane, to cytoplasmic and to nuclear receptor sites. It delivers high medication concentrations to specific cells with few side effects to other normal tissues. The general importance of this evaluation is to increase overall understanding of development of the therapeutic nanomedicine for the treatment of pancreatic tumors, agents delivered by nanoliposomes, liposomal nanomedicine in targeting cancer and safety issues.

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Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

Cited by 540 publications

References 116 publications

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment

Thermodynamic and kinetic characterization of pH-dependent interactions between bovine serum albumin and ibuprofen in 2D and 3D systems

Liposomes and Nanotechnology in Drug Development: Focus On Pancreatic Cancer

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Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

Cited by 540 publications

References 116 publications

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on&nbsp;the folate receptor-rich tumors treatment

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on&nbsp;the folate receptor-rich tumors treatment

Thermodynamic and kinetic characterization of pH-dependent interactions between bovine serum albumin and ibuprofen in 2D and 3D systems

Liposomes and Nanotechnology in Drug Development: Focus On Pancreatic Cancer

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Product

Resources

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The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment