Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods

Wang, Yanjie; Strohm, Eric M.; Sun, Yong; Wang, Zhaoxia; Zheng, Yuanyi; Wang, Zhigang; Kolios, Michael C.

doi:10.1364/boe.7.004125

Cited by 35 publications

(26 citation statements)

References 47 publications

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“…The authors claimed that the developed NPs may be used in vivo and in vitro for the diagnosis of different tumors. Wang et al [95] prepared optical activated NPs for photoacoustic/fluorescent imaging in cancer diagnosis. The NPs consisted of perfluorohexane liquid and gold nanoparticles (GNPs) in the core stabilized by a poly(lactide-co-glycolic acid) (PLGA) polymer.…”

Section: Diagnosis Of Cancermentioning

confidence: 99%

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Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

et al. 2020

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Cancer is a life-threatening disease killing millions of people globally. Among various medical treatments, nano-medicines are gaining importance continuously. Many nanocarriers have been developed for treatment, but polymerically-based ones are acquiring importance due to their targeting capabilities, biodegradability, biocompatibility, capacity for drug loading and long blood circulation time. The present article describes progress in polymeric nano-medicines for theranostic cancer treatment, which includes cancer diagnosis and treatment in a single dosage form. The article covers the applications of natural and synthetic polymers in cancer diagnosis and treatment. Efforts were also made to discuss the merits and demerits of such polymers; the status of approved nano-medicines; and future perspectives.

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Section: Diagnosis Of Cancermentioning

confidence: 99%

“…First of all, the polymeric micelles were introduced as drug delivery carriers in the early 1980s by Helmut Ringsdorf [162]. Besides, Genexol-PM formulation has got Food and Drugs Administration (FDA) consent for use in breast cancer treatment [95]. Some reviews have appeared on the use of micelles for drugs delivery [33,35].…”

Section: Polymeric Micellesmentioning

confidence: 99%

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

et al. 2020

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“…In vitro imaging of unstained CAKI-2 cells. Biological cells grown in culture are widely used in the study of drug efficacy, genome modification, and development of theranostic agents 48 . Adherent cells tend to have a ʽfried-eggʼ appearance; with an increased thickness near the nucleus that tapers toward the cell periphery 49,50 .…”

Section: Description Of the F-mode Techniquementioning

confidence: 99%

Photoacoustic F-Mode imaging for scale specific contrast in biological systems

et al. 2019

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In photoacoustic (PA) imaging, time domain reconstruction techniques are the current gold standard for image formation. While these techniques provide high-resolution spatial maps of optical absorption, they neglect the structural information encoded in the frequency domain of the broadband PA signals. In this work, we introduce a frequency domain technique for PA image formation, termed F-Mode. By leveraging information contained in the frequency content of PA signals, F-Mode can be used to generate images with scale-specific contrast. To demonstrate the robustness of our technique, we apply F-Mode to datasets acquired using both PA tomography and PA microscopy systems, utilizing linear array and singleelement transducers with central frequencies ranging from 40-400 MHz. Here we show that the technique can be used to: differentiate between vessels and microspheres of different size in phantoms, enhance visualization of organelles in cultured cells, and selectively display single blood vessels in vivo in zebrafish larvae.

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“…In contrast, the incorporation of lactide units tends to retard the degradation. Wang et al used PLGA to fabricate a biodegradable nanoparticle agent through the double emulsion method [77]. Herein, PLGA positioned in a polymer shell and imparted biodegradability as well as sufficient mechanical properties to the nanoparticles.…”

Section: Biodegradable Polymers As Pa Agentsmentioning

confidence: 99%

Biodegradable Contrast Agents for Photoacoustic Imaging

et al. 2018

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Over the past twenty years, photoacoustics—also called optoacoustics—have been widely investigated and, in particular, extensively applied in biomedical imaging as an emerging modality. Photoacoustic imaging (PAI) detects an ultrasound wave that is generated via photoexcitation and thermoelastic expansion by a short nanosecond laser pulse, which significantly reduces light and acoustic scattering, more than in other typical optical imaging and renders high-resolution tomographic images with preserving high absorption contrast with deep penetration depth. In addition, PAI provides anatomical and physiological parameters in non-invasive manner. Over the past two decades, this technique has been remarkably developed in the sense of instrumentation and contrast agent materials. In this review, we briefly introduce state-of-the-art multiscale imaging systems and summarize recent progress on exogenous bio-compatible and -degradable agents that address biomedical application and clinical practice.

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Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods

Cited by 35 publications

References 47 publications

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

Photoacoustic F-Mode imaging for scale specific contrast in biological systems

Biodegradable Contrast Agents for Photoacoustic Imaging

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