Biodegradable polyurethane/graphene oxide scaffolds for soft tissue engineering:<i>in vivo</i>behavior assessment

Ivanoska-Dacikj, Aleksandra; Bogoeva‐Gaceva, Gordana; Krumme, Andres; Tarasova, Elvira; Scalera, Chiara; Stojkovski, Velimir; Gjorgoski, Icko; Ristoski, Trpe

doi:10.1080/00914037.2019.1655754

Cited by 24 publications

(31 citation statements)

References 36 publications

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“…Furthermore, based on the collection of consecutive SEM images registered after FIB cutting and subsequent reconstruction of the investigated area, it is possible to obtain 3D information regarding particle shape and position inside electrospun fibers ( Cherpinski et al, 2019 ). Particles included inside the fibers affect their mechanical properties by increasing elastic modulus and tensile strength, changing their stiffness, and creating a more rigid scaffold ( Ramier et al, 2014 ; Kouhi et al, 2018 ; Ivanoska-Dacikj et al, 2020 ), but the availability of the bioactive compound is limited since they are inside and dependent on polymer degradation. A too high concentration of ceramic filler in blend electrospinning ( Kouhi et al, 2018 ; Ivanoska-Dacikj et al, 2020 ) can deteriorate mechanical properties, even below values for solely polymer fibers.…”

Section: Discussionmentioning

confidence: 99%

“…Particles included inside the fibers affect their mechanical properties by increasing elastic modulus and tensile strength, changing their stiffness, and creating a more rigid scaffold ( Ramier et al, 2014 ; Kouhi et al, 2018 ; Ivanoska-Dacikj et al, 2020 ), but the availability of the bioactive compound is limited since they are inside and dependent on polymer degradation. A too high concentration of ceramic filler in blend electrospinning ( Kouhi et al, 2018 ; Ivanoska-Dacikj et al, 2020 ) can deteriorate mechanical properties, even below values for solely polymer fibers. A similar effect of decreased mechanical performance was observed for fibers covered with an excess of particles, like in the case of applying electrospraying ( Ramier et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

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Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

Karbowniczek

Kaniuk

Berniak

et al. 2021

Front. Bioeng. Biotechnol.

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Hybrid materials combining organic and inorganic compounds used as scaffolds are highly beneficial in bone regeneration. In this study, we successfully produced by blend electrospinning poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) scaffolds enriched with hydroxyapatite (HA) particles to biomimic bone tissue for improved and faster regeneration processes. The morphology, fiber diameters, and composition of the scaffolds were investigated by scanning electron microscopy (SEM) techniques followed by focused ion beam (FIB) sectioning to verify HA particles integration with PHBV fibers. In vitro cell culture was performed for 7 days and followed with the cell proliferation test (CellTiter-Blue® Assay). Additionally, cell integration with the scaffold was visualized by confocal and SEM imaging. We developed a simple way of obtaining hybrid scaffolds by electrospinning PHBV solution with HA particles without any post-processing. The PHBV + HA scaffold enhanced cell proliferation and filopodia formation responsible for cell anchoring within the created 3D environment. The obtained results show the great potential in the development of hybrid scaffolds stimulating bone tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

Karbowniczek

Kaniuk

Berniak

et al. 2021

Front. Bioeng. Biotechnol.

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“…Here, in particular, silver stands out attributed to its distinctive physiochemical properties, and its demonstrated toxicity towards bacteria, fungi, virus, leishmania, malaria, and neoplastic [139]. A recent in-vivo study demonstrated that aqueous solution of colloidal Ag alone enabled effective sterilization of biodegradable PU based scaffolds [140]. The compressed-PU facial masks were modified with the hydrophobic coating to obtain the selfcleaning characteristic [141], to address the wetting and blocking water spatter in protective textiles used during COVID-19.…”

Section: Smart Textiles For Protective Clothingmentioning

confidence: 99%

Smart textiles and wearable technologies – opportunities offered in the fight against pandemics in relation to current COVID-19 state

Ivanoska-Dacikj

Stachewicz

2020

Reviews on Advanced Materials Science

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Recent outbreak of the COVID-19 pandemic has changed the world dramatically, posing profound challenges to our healthcare infrastructure, economic systems, social and cultural life but also to our freedom. What this pandemic made us realize so far, is that, despite the tremendous advances in medicine and pharmacy, in the initial moments, which are crucial in the containment of spreading of any pandemic, the key role is played by the non-pharmaceutical measures. These measures are the ones that bridge the time between pandemic outbreaks and the development of drugs or vaccines and are crucial for the number of human lives spared. Smart textiles and novel materials as part of the personal protective equipment (PPE) and telemedicine are crucial factors in the healthcare system. Here, we present an overview on the use of textiles in the fight against pandemics, in the past and current COVID-19, we analyze the morphology of the commonly used face masks, made of cotton and typically used polypropylene (PP). We also present the perspective that smart textiles, wearable technologies and novel materials are offering in the fight against future pandemics, mainly as part of the personal protective equipment and telemedicine.

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“…Its setup is very simple (consisting of a high-voltage power supply, a syringe pump and a grounded collector) and can be easily implemented not only on a lab scale, but also in large-scale production. Both synthetic (such as polyglycolides [13], polylactides [14], polycaprolactone [13,15] and polyurethane [16][17][18][19]) and natural polymers (such as collagens [20], gelatine [14], alginates [21], chitosans [20,22] and silk fibroin [14]) have been electrospun to be used for biomedical application. The success of electrospun scaffolds in tissue engineering application depends on how closely they mimic the native ECM in terms of composition, structure and porosity [3], but also conductivity [23].…”

Section: Introductionmentioning

confidence: 99%

Electrospun PEO/rGO Scaffolds: The Influence of the Concentration of rGO on Overall Properties and Cytotoxicity

Ivanoska-Dacikj

Makreski

Geškovski

et al. 2022

IJMS

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Reduced graphene oxide (rGO) is one of the graphene derivatives that can be employed to engineer bioactive and/or electroactive scaffolds. However, the influence of its low and especially high concentrations on scaffolds’ overall properties and cytotoxicity has yet to be explored. In this study, polyethylene oxide (PEO)-based scaffolds containing from 0.1 to 20 wt% rGO were obtained by electrospinning. Morphological, thermal and electrical properties of the scaffolds were characterized by SEM, Raman spectroscopy, XRD, DSC and electrical measurements. The diameter of the fibers decreased from 0.52 to 0.19 µm as the concentration of rGO increased from 0.1 wt% to 20 wt%. The presence of rGO above the percolation threshold (5.7 wt%) resulted in a significantly reduced electrical resistivity of the scaffolds. XRD and Raman analysis revealed delamination of the graphene layers (interlayer spacing increased from 0.36 nm to 0.40–0.41 nm), and exfoliation of rGO was detected for the samples with an rGO concentration lower than 1 wt%. In addition, an evident trend of increasing cell viability as a function of the rGO concentration was evidenced. The obtained results can serve as further guidance for the judicious selection of the rGO content incorporated into the PEO matrix for constructing electroactive scaffolds.

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Biodegradable polyurethane/graphene oxide scaffolds for soft tissue engineering:in vivobehavior assessment

Cited by 24 publications

References 36 publications

Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

Smart textiles and wearable technologies – opportunities offered in the fight against pandemics in relation to current COVID-19 state

Electrospun PEO/rGO Scaffolds: The Influence of the Concentration of rGO on Overall Properties and Cytotoxicity

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