Biodegradation Control of Chitosan Materials by Surface Modification with Copolymers of Glycidyl Methacrylate and Alkyl Methacrylates

Abstract

Chitosan is one of promising polymer from natural polysaccharides, which is an environmentally friendly compound from renewable raw materials. Chitosan has biodegradability, biocompatibility, and exhibits antimicrobial, antibacterial, and other activities. In this article, we report the rst use of copolymers based on glycidyl methacrylate and ( uoro)alkyl methacrylates as material surface wettability modi ers based on a chitosan, and we show that grafting of copolymers allows an increase in the hydrophobicity of lms with contact angles up to 114° and up to 154° for aerogels. The resulting chitosan aerogels have high porosity with a pore size of 100-200 µm and the pore walls are 0.6-0.7 µm-thick lm formations. Our study of lyophilic properties of modi ed chitosan substrates showed a change in the hydrophobicity of the materials as a function of length of the hydrocarbon radical in the side groups of ( uoro)alkyl methacrylates in the copolymers. Additionally, the rate of biodegradation of the resulting materials decreased with an increase in the number of hydrophobic groups in the modi er. Obtained chitosan materials with hydrophobic coatings have potential as a protective layer for wound dressings with an extended service life.

Chitosan-Based Hydrogel in the Management of Dermal Infections: A Review

“…Biodegradation control: Chitosan hydrogels can undergo rapid enzymatic degradation in the presence of chitosanases and lysozymes, limiting their long-term stability and durability [166]. Controlling the biodegradation rate is essential to match the intended application, allowing sufficient time for tissue regeneration or drug release while maintaining the structural integrity of the hydrogel.…”