Furfural with a chemical formula of C 5 H 4 O 2 is a toxic compound which has several health problems for both humans and environment. It has a few exposure routes for entering the human body such as oral, dermal or nasal. In the present study, the efficacies of an integrated catalytic ozonation process (COP) and novel cyclic biological reactor (CBR) were explored for the removal of furfural from aqueous solutions. Activated carbon was purchased from Merck Company. It had a Brunauer, Emmett, and Teller (BET) specific surface area of 1100 m 2 /g, with an average micropore volume and size of 0.385 cm 3 /g and 595 µm, respectively. The results indicated that 30% pretreatment with COP could increase furfural and chemical oxygen demand (COD) removal efficiency with CBR 5.56% and 27.01%, respectively. With 70% pretreatment by COP, 98.57% furfural and 95.34% COD removal efficiencies happen in CBR. Generally, batch and continuous experiments showed that the integrated COP/CBR could be efficient in eliminating furfural from wastewater and thus may be a promising technique for treating furfural-containing wastewater.