1995
DOI: 10.1002/bit.260480610
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Biodegradation of nitrobenzene through a hybrid pathway in Pseudomonas putida

Abstract: The biodegradation of nitrobenzene was attempted by using Pseudomonas putida TB 103 which possesses the hybrid pathway combining the tod and the tol pathways. Analysis of the metabolic flux of nitrobenzene through the hybrid pathway indicated that nitrobenzene was initially oxidized to cis-1,2-dihydroxy-3-nitrocyclohexa-3,5-diene by toluene dioxygenase in the tod pathway and then channeled into the tol pathway, leading to the complete biodegradation of nitrobenzene. A crucial metabolic step redirecting the met… Show more

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Cited by 14 publications
(4 citation statements)
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“…Nitrobenzene was also thought to belong to this group until relatively recently but there is now direct evidence of the formation of nitrobenzene cis-dihydrodiol with a number of TDO-containing organisms. 47,48 However, in spite of these exceptions, the dioxygenase enzymes are capable of accepting arene substrates with a remarkably wide range of substituent types; from electron-donating groups (e.g. methoxy) to strongly electron-withdrawing groups (e.g.…”
Section: Classification Of Substratesmentioning
confidence: 99%
“…Nitrobenzene was also thought to belong to this group until relatively recently but there is now direct evidence of the formation of nitrobenzene cis-dihydrodiol with a number of TDO-containing organisms. 47,48 However, in spite of these exceptions, the dioxygenase enzymes are capable of accepting arene substrates with a remarkably wide range of substituent types; from electron-donating groups (e.g. methoxy) to strongly electron-withdrawing groups (e.g.…”
Section: Classification Of Substratesmentioning
confidence: 99%
“…Nitrobenzene (NB), one of the recalcitrant nitroaromatic compounds, has been reported to be mineralized by microorganisms through oxidative (25) and partial reductive pathways (11,24). In addition, construction of a hybrid pathway for the degradation of NB was attempted with Pseudomonas putida TB103 (13). Recently, Pseudomonas pseudoalcaligenes JS45 was reported to have a partial reductive pathway, and several enzymes involved in NB catabolism were purified and characterized (10,12,19,37).…”
mentioning
confidence: 99%
“…These compounds have been listed as priority pollutants by the European Economic Community. Much effort has been dedicated to the microbial degradation of nitro-and chloroaromatic compounds, and their degradative pathways have been revealed in detail (5,11,14,22,23,27,30,32). Even though biodegradation of 3-CNB by sludge samples was attempted (18), studies on the microbial degradation of CNBs have been rare.…”
mentioning
confidence: 99%
“…strain JS150 (11). In our previous work, a hybrid pathway for the degradation of NB was designed in P. putida TB103 (14). In this pathway, NB was initially oxidized to NB-cis-dihydrodiol by toluene dioxygenase, and then this intermediate was converted to catechol by the action of toluate cis-dihydrodiol dehydrogenase.…”
mentioning
confidence: 99%