Biodegradation of the ZnO:Eu nanoparticles in the tissues of adult mouse after alimentary application

Kiełbik, Paula; Kaszewski, Jarosław; Rosowska, Julita; Wolska, E.; Witkowski, B.S.; Gralak, Mikołaj Antoni; Gajewski, Zdzisław; Godlewski, M.; Godlewski, M

doi:10.1016/j.nano.2016.11.002

Cited by 40 publications

(38 citation statements)

References 24 publications

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“…5), the NP-related red fluorescence is very dim. This could be explained by the low NP content in kidney cells, similar to previous observations (5,12).…”

Section: Resultssupporting

confidence: 89%

“…4) indicate the possibility of the distribution of NP-lectin complexes via the portal vein to the liver, where some complexes undergo dissolution whereas others undergo further distribution (1,2). Although changes in the cell index between the time points shown in figure 4 for NP-lectin-positive cells were statistically insignificant, they were similar to fluctuations in free NPs in the liver during distribution and redistribution patterns of NPs described previously (1,2,5).…”

Section: Resultssupporting

confidence: 85%

“…In the field of biomedicine, one of the most researched applications are drug delivery systems (DDS) (7,8). Many NPs exhibit properties advantageous for DDS, such as the ease of modification, low toxicity, ability to penetrate physiological barriers, favourable biodistribution, biocompatibility and biodegradability (3,5,(9)(10)(11)(12)(13)(14)(15). Furthermore, NPs may also protect a drug from degradation and increase its biological stability, bioavailability and retention time.…”

Section: Praca Oryginalnamentioning

confidence: 99%

“…Marek Godlewski's team from the Institute of Physics, Polish Academy of Sciences (IP PAS), have developed NPs based on wide band-gap semiconductor metal oxides doped with rare earth metal ions to activate their fluorescence (3,5,(11)(12)(13). These NPs, in addition to their strong fluorescence, exhibit many properties important for DDS.…”

Section: Praca Oryginalnamentioning

confidence: 99%

“…Their surface can be easily modified because it is terminated by hydroxide groups. They exhibited low toxicity (2,5), could penetrate physiological barriers, including intestinal and blood-brain barrier and were widely distributed within the body (3,5,(11)(12)(13). In addition, these NPs were either biocompatible or biodegradable (5).…”

Section: Praca Oryginalnamentioning

confidence: 99%

See 4 more Smart Citations

Wide band-gap oxide nanoparticles as potential drug carriers

Lipinski

Kaszewski

Gajewski

et al. 2017

Medycyna Weterynaryjna

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SummaryRecent decades have brought rapid development in the field of nanotechnology, which has led to applications of nanoparticles in many industries. Unique properties of nanoparticles and their biocompatibility increase their potential as drug carriers in drug-delivery systems. Prof. Marek Godlewski's team from the Institute of Physics PAS has developed wide band-gap metal oxide nanoparticles doped with rare-earth metals for applications as fluorescent markers. The potential of those nanoparticles to cross the closed gut barrier after alimentary application has prompted their use in drug delivery systems. In this study, we show that after conjugation with a model bioactive substance, lectin (Phaseolus vulgaris), these nanoparticles retained their advantageous properties and, following oral administration (10 mg/ml in RO, 0.3 ml/mouse), entered a variety of organs in the mouse model. Internal organs collected at key time points were analysed under a scanning cytometer and a confocal microscope. The results show that the conjugation reduced, but did not completely abolish, the capacity of nanoparticles to penetrate physiological barriers (intestinal, blood-brain barrier) in the organism.

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“…5), the NP-related red fluorescence is very dim. This could be explained by the low NP content in kidney cells, similar to previous observations (5,12).…”

Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 85%

Section: Praca Oryginalnamentioning

confidence: 99%

Section: Praca Oryginalnamentioning

confidence: 99%

Section: Praca Oryginalnamentioning

confidence: 99%

See 3 more Smart Citations

Wide band-gap oxide nanoparticles as potential drug carriers

Lipinski

Kaszewski

Gajewski

et al. 2017

Medycyna Weterynaryjna

Self Cite

View full text Add to dashboard Cite

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Zinc Oxide Nanoparticles Incorporated in Poly‐Hydroxyethyl Methacrylate/Acrylamide Membrane Trigger the Key Events of Full‐Thickness Wound Healing in a Rabbit Model

Saha,

Roy,

Jana

et al. 2024

J Biomed Mater Res

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Zinc oxide nanoparticles are known to possess anti‐inflammatory, antibacterial, and antiseptic properties and find wide application in the preparation of topical ointments. Wound dressings in the form of hydrogels can replenish the wound microenvironment to aid the healing process in a multidimensional way. We have fabricated a composite hydrogel using 1–3 wt. % ZnO nano‐particles, synthesized by chelation reaction, and poly‐2‐hydroxyethyl methacrylate (pHEMA)/acrylamide, synthesized, and co‐polymerized in 8 kGy gamma irradiation. Developed powders and composite membranes have been thoroughly analyzed for XRD, FTIR, SEM–EDX mapping, DTA/TGA, particle size, shape, morphology, porosity, water uptake, and contact angle. Thermally stable phase‐pure ZnO spherical nanoparticles with an average crystallite size of 40 ± 2 nm have been used for fabricating well‐dispersed composite with contact angle varying 78o–88o. These membranes, when used in vivo, rendered a suitable environment conducive to tissue regeneration and ECM component deposition sequentially. Endowed with antibacterial properties, these hydrogels also demonstrated excelling swelling capacity which proved beneficial in maintaining a moist wound environment aiding in the healing process. An earlier wound closure was achieved with 2%–3% ZnO‐pHEMA/acrylamide hydrogels which demonstrate the potential of ZnO nanoparticles in signaling and instructing the wound bed milieu towards the efficient repair.

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Green Essence of Plant Resources Capped Zinc Oxide Nanoparticles: Renewable Distinctions, Size‐Shape‐Modulated Physicochemical Diversity and Emerging Biomedical‐Environmental Usefulness

Malik,

Rani,

Khan

et al. 2024

Part & Part Syst Charact

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The natural essence, biocompatibility, and pleiotropic functioning of plant polyphenols have swiftly emerged as integrated assets for biomedical and environmental applications of plant resources capped ZnO NPs. Simultaneous reducing cum capping abilities, synergistic edible prospects, and precursor‐plant extract stoichiometry‐driven robust size‐shape modulation are the major encouragements being explored for increasing recent interest in biomedical‐environmental applications of plant extracts (PEs) capped ZnO NPs. The structure‐function dynamics of extracts from leaves, roots, fruits, seeds, and whole plants sum up the multifaceted applications of polyphenols‐capped ZnO NPs. Recent interest in plant resources' biomedical and environmental utility capped ZnO NPs mandates discussing the correlative mechanisms for sustainable future insights. PEs capped ZnO NPs as drug carriers and sensing agents significantly moderate the toxic chemotherapeutic drug intake via enhanced tumor cell internalization, aided by synergistic immune‐modulating actions of constituent phytochemicals. On the environmental front, integrated antioxidant features of plant resources and ZnO NPs make them potent degrading agents for the sustainable degradation of persisting effluents. Keeping the above aspects in mind, this review article focuses on the correlative mechanisms underlying the biomedical and environmental remediation applications of plant resources made ZnO NPs. This article would augment the awareness of ZnO NPs multifaceted applications for consolidating the understanding of predictive mechanistic controls.

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Biodegradation of the ZnO:Eu nanoparticles in the tissues of adult mouse after alimentary application

Cited by 40 publications

References 24 publications

Wide band-gap oxide nanoparticles as potential drug carriers

Wide band-gap oxide nanoparticles as potential drug carriers

Zinc Oxide Nanoparticles Incorporated in Poly‐Hydroxyethyl Methacrylate/Acrylamide Membrane Trigger the Key Events of Full‐Thickness Wound Healing in a Rabbit Model

Green Essence of Plant Resources Capped Zinc Oxide Nanoparticles: Renewable Distinctions, Size‐Shape‐Modulated Physicochemical Diversity and Emerging Biomedical‐Environmental Usefulness

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