Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites

Pighinelli, Luciano; Kucharska, Magdalena; Wiśniewska‐Wrona, Maria; Gruchała, Bogdan; Brzoza-Malczewska, Kinga

doi:10.3390/ijms13067617

Cited by 14 publications

(12 citation statements)

References 19 publications

(12 reference statements)

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“…In the spectrum of the HAp sample, the peaks that are observed, Figure 1, 839 (cm 1 ) that correspond to deformation modes of phosphate groups (O-P-H) bonds, associated with energy level and the kind of neighbourhood that are linked with the rotational type of the bond O-H. In 3570 cm -1 and 3464 cm -1 is observed also the OH -group peak, referring to the way they stretch.…”

Section: Resultsmentioning

confidence: 98%

“…Bone consists of 69% calcium phosphate (mainly hydroxyapatite), 21% collagen, 9% water and 1% other constituents. It has a composite nature which is built up of mainly ceramic (hydroxyapatite) and polymer (collagen), with a complex hierarchical microstructure very difficult to imitate which gives most of the superior mechanical properties to bone [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Properties of Hydrochloric Chitosan Solutions Modified With Nano- Calcium Phosphate Complex.

Pighinelli¹,

Mf²,

Rl³

2015

J Tissue Sci Eng

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Nature itself uses materials like cellulose to provide the structure of plants, chitin as the exoskeleton of several insects and molluscs, collagen for mechanical support in connective tissues and so on. At present, the socioeconomic situation of the modern world has raised the interest in renewable materials to use in regenerative medicine. The composition of Chitosan and/or Calcium Phosphates are derived from the junction of two or more different materials, containing organic and inorganic materials, including characteristics of both materials like bioactivity and biodegradability and biocompatibility with human tissues.The chemical characteristics of chitosan and nano B-TCP / HAp complex showed that both of the components organic and inorganic exist in the material showing a good stability of the nano-ceramic formation in the chitosan salt solutions. All complex by Zeta-Potential, showing also a new method of preparations nanoparticles of calcium phosphates in chitosan solution from commercial calcium phosphates in micro size. These materials can be used in future for medical applications as a base for scaffolds production and as implants in regenerative medicine.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Properties of Hydrochloric Chitosan Solutions Modified With Nano- Calcium Phosphate Complex.

Pighinelli¹,

Mf²,

Rl³

2015

J Tissue Sci Eng

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“…The importance of natural polymers, such as microcrystalline chitosan, and minerals, such as hydroxyapatite (HAp) and tricalcium phosphate (TCP), has grown significantly due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. The excellent biocompatibility, biofunctionality, and nonantigenic property make the chitosan (Ch) and its derivatives, such as a microcrystalline chitosan (MCCh), an ideal material for tissue regeneration [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan was chosen as a biomaterial because of its biocompatibility, biodegradability, and nontoxicity [18,19]. It can be used as an individual compound in a carrier [13,14] or in combination with other polymers (fibrin, gelatin, collagen, and heparin) [20][21][22][23][24] and inorganic substances [15,16]. Ch is a biodegradable cationic polysaccharide composed of (1 → 4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit) which is known to accelerate wound healing and bone formation [15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Microcrystalline Chitosan and Fibrin Membranes as Platelet-Derived Growth Factor-BB Carriers with Amoxicillin

Bodek

Nowak

Kozakiewicz

et al. 2015

International Journal of Polymer Science

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The aim of this study was to describe the mechanical and sorption features of homogeneous and composite membranes which consist of microcrystalline chitosan (MCCh) and fibrin (Fb) in various proportions as well as thein vitrokinetics of platelet-derived growth factor-BB (PDGF-BB) released from ten types of membranes in the presence or absence of amoxicillin (Am). The films were characterized by Fourier transform infrared (FTIR) spectroscopy, mechanical tests: breaking strength (Bs) and elongation at break (Eb), as well as SEM images, and swelling study. The influence of the form of samples (dry or wet) on Young’s modulus (E) was also examined. The homogeneous MCCh (M1) and composite M3 and M4 (MCCh : Fb = 2 : 1 and 1 : 1) membranes were characterized by good sorption properties and higher mechanical strength, when compared with Fb (M2) membrane. Connecting MCCh with Fb decreases release of PDGF-BB and increases release of Am. The most efficient release of PDGF-BB was observed in the case of M4 (the optimum MCCh : Fb ratio was 1 : 1) membrane. It was found that the degree of PDGF-BB release from the membrane is influenced by the physicochemical and mechanical characteristics of the films and by its affinity to growth factor PDGF-BB.

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“…MCCh is a safe and effective biopolymer for the achievement of hemostasis at puncture sites . This natural polysaccharide shows unique biostimulating properties, that is, the reconstruction and vascularization of damaged tissues . The most important and the most extraordinary property MCCh is that the films from the aqueous dispersion directly formed.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

Nowak

Szterk

Szymborski

et al. 2015

J of Applied Polymer Sci

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In this article, we present a potential use of biodegradable polymers as a drug‐delivery system designed for alveolar osteitis (AO) management. The release characteristics of lidocaine hydrochloride from alginate or hyaluronate xerogels, which covered the microcrystalline chitosan scaffold, were examined as drug carriers, wound dressings, and potential devices in bone regeneration. The materials were characterized by Fourier transform infrared spectroscopy to confirm that there was no additional covalent bonding between the polymeric membranes and the anesthetic agent. Surface‐eroding matrices (ca. 120 μm) encapsulated the main substance, and the morphologies of all of the structures were measured by scanning electron microscopy. Positive results were obtained, and the data suggested an important impact of materials selection on the physicochemical properties and drug release. Additionally, the mechanical properties, such as the hardness, adhesiveness, springiness, and cohesiveness, of the tested materials were evaluated. A study of the swelling confirmed one of the assumptions that the materials could be used as a potential wound dressing and emphasized the resistance of the materials in the condition imitating the movement of the masticatory system. A cytotoxicity test of the formulations was performed to prove the materials’ nontoxicity. The aim of this study was to design and propose an in vitro evaluation of a new drug formulation as a potential application for the treatment of AO. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42991.

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Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites

Cited by 14 publications

References 19 publications

Properties of Hydrochloric Chitosan Solutions Modified With Nano- Calcium Phosphate Complex.

Properties of Hydrochloric Chitosan Solutions Modified With Nano- Calcium Phosphate Complex.

Evaluation of Microcrystalline Chitosan and Fibrin Membranes as Platelet-Derived Growth Factor-BB Carriers with Amoxicillin

In vitro evaluation of polymeric formulations designed for use in alveolar osteitis

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