Biodistribution and PET imaging of 89-zirconium labeled cerium oxide nanoparticles synthesized with several surface coatings

McDonagh, Philip Reed; Sundaresan, Gobalakrishnan; Yang, Likun; Sun, Minghao; Mikkelsen, Ross B.; Zweit, Jamal

doi:10.1016/j.nano.2018.04.002

Cited by 26 publications

(17 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The bone uptake is indicative of 89 Zr detaching from the radio-conjugate and accumulation in bone. This observation has been reported in other studies [27] [28] [29]. The overall biodistribution of [ 89 Zr]-DFO-SB5 (specific for SAS1B) and [ 89 Zr]-DFO-3A4 (presumed to be non-specific for SAS1B) is similar across several tissues, including blood.…”

Section: Discussionsupporting

confidence: 86%

Labeling of Anti-SAS1B with Zirconium-89 as a Novel Immune-PET Probe for Uterine Cancer Imaging

Elmekharam¹,

Sundaresan²,

Thadigiri³

et al. 2021

JBM

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 86%

Labeling of Anti-SAS1B with Zirconium-89 as a Novel Immune-PET Probe for Uterine Cancer Imaging

Elmekharam¹,

Sundaresan²,

Thadigiri³

et al. 2021

JBM

Self Cite

View full text Add to dashboard Cite

“…Cerium oxide NPs have unique surface chemistry. Cerium oxide NPs coated with 89 Zr , a clinical PET isotope, for PET imaging and in vivo biodistribution were synthesized and showed great potential to be used in PET imaging [ 62 ].…”

Section: Medical Imagingmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

View full text Add to dashboard Cite

Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

show abstract

“…McDonagh et al [57] deve synthesis of several coated Cerium oxide nanoparticles (CONPs) and an efficient intrinsic core labeling of CONPs with the clinical PET isotope, zirconium PET imaging and ex-vivo biodistribution. The result demonstrated, poly (acrylic acid) coated CONPs shown excellent candidacy for clinical implementation due to their enhanced renal clearance and low reticuloendothelial system uptake.…”

Section: Itron Emission Tomography (Pet)mentioning

confidence: 99%

A literature review on multimodality molecular imaging nanoprobes for cancer detection

Shahbazi‐Gahrouei

Khaniabadi

Shahbazi-Gahrouei

et al. 2019

Polish Journal of Medical Physics and Engineering

View full text Add to dashboard Cite

Molecular imaging techniques using nanoparticles have significant potential to be widely used for the detection of various types of cancers. Nowadays, there has been an increased focus on developing novel nanoprobes as molecular imaging contrast enhancement agents in nanobiomedicine. The purpose of this review article is to summarize the use of a variety of nanoprobes and their current achievements in accurate cancer imaging and effective treatment. Nanoprobes are rapidly becoming potential tools for cancer diagnosis by using novel molecular imaging modalities such as Ultrasound (US) imaging, Computerized Tomography (CT), Single Photon Emission Tomography (SPECT) and Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI), and Optical Imaging. These imaging modalities may facilitate earlier and more accurate diagnosis and staging the most of cancers.

show abstract

Biodistribution and PET imaging of 89-zirconium labeled cerium oxide nanoparticles synthesized with several surface coatings

Cited by 26 publications

References 55 publications

Labeling of Anti-SAS1B with Zirconium-89 as a Novel Immune-PET Probe for Uterine Cancer Imaging

Labeling of Anti-SAS1B with Zirconium-89 as a Novel Immune-PET Probe for Uterine Cancer Imaging

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

A literature review on multimodality molecular imaging nanoprobes for cancer detection

Contact Info

Product

Resources

About