Biodistribution and radiation dosimetry of 82Rb at rest and during peak pharmacological stress in patients referred for myocardial perfusion imaging

Abstract

The current effective dose estimate in CAD patients is four times lower than the values reported previously by the ICRP, and about 35% lower than previous in vivo studies in young healthy subjects.

High-precisionγ-ray spectroscopy of the cardiac PET imaging isotopeRb82and its impact on dosimetry

“…The low effective dose received by patients reported in Ref. [5] does not appear to be due to any deficiency in the actual nuclear decay scheme, and so must be attributed to biological effects. We believe this result is somewhat fortuitous, due to a cancellation between renormalization and the contribution of the new gamma γ-rays, and other medical isotopes may show considerable modification to their dosimetric properties when contemporary spectroscopy is performed.…”

“…There are currently significant discrepancies in estimates of the absorbed dose from 82 Rb treatment [4]. A recent study [5] finds the effective dose four times lower than that recommended by the International Commission on Radiological Protection (ICRP) [6]. There are two components involved in calculating the absorbed dose: a nuclear physics component factoring in the revelant properties of the decay (half-life, γ-and β energies and intensities) and a kinetic component which involves exactly how the radiation is transported and cataloged in the different tissues and organs.…”

Status of cardiovascular PET radiation exposure and strategies for reduction: An Information Statement from the Cardiovascular PET Task Force

“…11 However, achieving these doses requires close adherence to imaging standards and adapting protocols to meet the needs of each patient. Laboratories should be aware that recommended patient doses can vary based on PET instrumentation.…”

Current Status of Myocardial Perfusion PET in the United States

“…A typical rest/stress Tc-99m SPECT exposes a patient to about 12 mSv of radiation, compared to about 3 for a rest/stress PET study (13)(14)(15). This is an important consideration for younger patients, and for those with chronic CAD who are likely to receive high radiation burdens during their years of coping with this chronic disease.…”