Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans

Abstract

For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [F]Mefway PET scan.

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors

“…Other human PET studies suggested an estimated effective dose of 40.23 μSv/MBq 137 and optimal imaging timing of 60−80 min 138 for [ 18 F]trans-27, and this radioligand was demonstrated to metabolize through the gastrourinary tract. 137 In a recent PET study with major depressive episode patients, 139 [ 18 F]trans-27 could efficiently evaluate the 5-HT 1A receptor density but failed to discriminate the therapeutic response. As a result, [ 18 F]trans-27 exhibited great potential in clinical PET studies of neurologic and psychiatric disorders that affect the mesial temporal lobe.…”

“…Fortunately, no accumulation of the radioactivity was observed in the bone (no substantial in vivo defluorination). Other human PET studies suggested an estimated effective dose of 40.23 μSv/MBq and optimal imaging timing of 60–80 min for [ 18 F] trans - 27 , and this radioligand was demonstrated to metabolize through the gastrourinary tract . In a recent PET study with major depressive episode patients, [ 18 F] trans - 27 could efficiently evaluate the 5-HT 1A receptor density but failed to discriminate the therapeutic response.…”