Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis <i>via</i> scintigraphy

Raj, Pooja Mongia; Raj, Rakesh; Kaul, Ankur; Mishra, Anil K.; Ram, Alpana

doi:10.1039/c8ra01898g

Cited by 47 publications

(26 citation statements)

References 68 publications

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“…Other options such as chitosan, a chitin derivative, have been shown to increase epithelial permeability by affecting TJs. When formulated as a cationic coating for nanostructured lipid carriers, researchers have observed increased delivery across a membrane and stronger pharmacological response [ 75 , 76 , 77 ]. Given the constrictions imposed by mucus on the types of drugs, this can provide a broad range of drugs access to this administration route.…”

Section: Factors Affecting Intranasal Drug Deliverymentioning

confidence: 99%

Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System

Crowe

Hsu

2022

Pharmaceutics

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Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies. The development of neuroprotective or curative therapies is limited by a variety of factors, but none more than the highly selective blood-brain barrier. Intranasal administration can bypass this barrier completely and allow direct access to brain tissues, enabling a large number of potential new therapies ranging from bioactive peptides to stem cells. Current research indicates that merely administering simple solutions is inefficient and may limit therapeutic success. While many therapies can be delivered to some degree without carrier molecules or significant modification, a growing body of research has indicated several methods of improving the safety and efficacy of this administration route, such as nasal permeability enhancers, gelling agents, or nanocarrier formulations. This review shall discuss promising delivery systems and their role in expanding the clinical efficacy of this novel administration route. Optimization of intranasal administration will be crucial as novel therapies continue to be studied in clinical trials and approved to meet the growing demand for the treatment of patients with neurological diseases.

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Section: Factors Affecting Intranasal Drug Deliverymentioning

confidence: 99%

Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System

Crowe

Hsu

2022

Pharmaceutics

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“…They found that the mucoadhesive property of chitosan allowed these NPs to predominantly accumulate in the intestinal mucosa with a gastric retention time of 8 h and the majority of radioactivity observed in the colon after 24 h. There was minimal systemic absorption and accumulation in internal organs [146]. Similarly, colon-targeted curcumin-loaded chitosan NPs coated with Eudragit FS 30D were found to retain highly in the colon with little accumulation in other organs [147]. Navarro et al reported less than 1% accumulation of chitosan NPs in the spleen, liver, kidneys, heart, lungs, and brain after oral administration of fluorescent tagged FITC-PLGA-chitosan NPs daily for 7 days and attributed these findings to chitosan's mucoadhesive properties and the rapid elimination from the systemic circulation [148].…”

Section: Effect Of Mucosal Routes Of Administrationmentioning

confidence: 99%

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

et al. 2021

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The unique properties of chitosan make it a useful choice for various nanoparticulate drug delivery applications. Although chitosan is biocompatible and enables cellular uptake, its interactions at cellular and systemic levels need to be studied in more depth. This review focuses on the various physical and chemical properties of chitosan that affect its performance in biological systems. We aim to analyze recent research studying interactions of chitosan nanoparticles (NPs) upon their cellular uptake and their journey through the various compartments of the cell. The positive charge of chitosan enables it to efficiently attach to cells, increasing the probability of cellular uptake. Chitosan NPs are taken up by cells via different pathways and escape endosomal degradation due to the proton sponge effect. Furthermore, we have reviewed the interaction of chitosan NPs upon in vivo administration. Chitosan NPs are immediately surrounded by a serum protein corona in systemic circulation upon intravenous administration, and their biodistribution is mainly to the liver and spleen indicating RES uptake. However, the evasion of RES system as well as the targeting ability and bioavailability of chitosan NPs can be improved by utilizing specific routes of administration and covalent modifications of surface properties. Ongoing clinical trials of chitosan formulations for therapeutic applications are paving the way for the introduction of chitosan into the pharmaceutical market and for their toxicological evaluation. Chitosan provides specific biophysical properties for effective and tunable cellular uptake and systemic delivery for a wide range of applications.

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“…In vivo distribution revealed good accumulation of chitosan nanoparticles in the colonic region. 24 Histone particles showed high positive surface charge (+24.6 ± 1.7 mV), as shown in Figure S2. Critically, histone exhibited strong mucoadhesion properties, and it showed 23.9 ± 0.5% binding to excised rat colon, whereas the negatively charged albumin nanoparticles showed only 2.3 ± 1.3% (Figure 2I).…”

Section: ■ Results and Discussionmentioning

confidence: 89%

“…Similarly, curcumin loaded chitosan nanoparticles were prepared by ionic gelation and solvent evaporation method. In vivo distribution revealed good accumulation of chitosan nanoparticles in the colonic region . Histone particles showed high positive surface charge (+24.6 ± 1.7 mV), as shown in Figure S2.…”

Section: Resultsmentioning

confidence: 92%

Cross-linked Histone as a Nanocarrier for Gut Delivery of Hydrophobic Cargos

Mabrouk

Zhang

Zidan

et al. 2021

ACS Appl. Mater. Interfaces

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Delivering hydrophobic molecules through the intestine can be challenging due to limited cargo solubility and the harsh biochemical environment of the stomach. Here, we show that a protein-based nanocarrier system based on the abundant protein histone and the natural cross-linker genipin can deliver hydrophobic cargos, such as dyes and therapeutic molecules, through the gastrointestinal tract. Using hydrophobic near-infrared dyes as model cargos, a panel of potential protein carriers was screened, and histone was identified as the one with the best loading capability. The resulting nanoparticles had a positive ζ potential and were mucoadhesive. Cross-linking of the amine-rich nanocarrier with genipin was particularly effective relative to other proteins and increased the stability of the system during incubation with pepsin. Cross-linking was required for successful delivery of a hydrophobic dye to the colon of mice after oral gavage. To assess the platform for therapeutic delivery, another hydrophobic model compound, curcumin, was delivered using cross-linked histone nanoparticles in a murine colitis model and significantly alleviated the disease. Taken together, these results demonstrate that histone is a cationic, mucoadhesive, and cross-linkable protein nanocarrier that can be considered for oral delivery.

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Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

Cited by 47 publications

References 68 publications

Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System

Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

Cross-linked Histone as a Nanocarrier for Gut Delivery of Hydrophobic Cargos

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