Biodistribution of poly clustered superparamagnetic iron oxide nanoparticle labeled mesenchymal stem cells in aminoglycoside induced ototoxic mouse model

Ahn, Ye Ji; Yun, Wan Su; Choi, Jin Woo; Kim, Woo Cheol; Lee, Su Hoon; Park, Jeong Eun; Key, Joe L.; Seo, Young Joon

doi:10.1007/s13534-020-00181-6

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…Recent studies have demonstrated that SPIO NPs could be endocytosed by SGNs to promote the development of growth cones and neurite extension of SGNs with or without a magnetic field (Hu et al, 2021). In a study by Ye et al, SPIO NPs, after being endocytosed by mesenchyme stem cells (MSCs), induced the migration and homing of MSCs toward mouse cochleae under an external magnetic field, either by intratympanic or tail vein administration (Ahn et al, 2021). The movement of SPIO NPs relies on the magnetic field, a relatively less traumatic operation, which undoubtedly provides novel options for the application of stem cells in the inner ear as well as the neurite growth direction of regenerated SGNs.…”

Section: Superparamagnetic Iron Oxidementioning

confidence: 99%

Current advances in biomaterials for inner ear cell regeneration

Lu,

Wang,

Meng

et al. 2024

Front. Neurosci.

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Inner ear cell regeneration from stem/progenitor cells provides potential therapeutic strategies for the restoration of sensorineural hearing loss (SNHL), however, the efficiency of regeneration is low and the functions of differentiated cells are not yet mature. Biomaterials have been used in inner ear cell regeneration to construct a more physiologically relevant 3D culture system which mimics the stem cell microenvironment and facilitates cellular interactions. Currently, these biomaterials include hydrogel, conductive materials, magneto-responsive materials, photo-responsive materials, etc. We analyzed the characteristics and described the advantages and limitations of these materials. Furthermore, we reviewed the mechanisms by which biomaterials with different physicochemical properties act on the inner ear cell regeneration and depicted the current status of the material selection based on their characteristics to achieve the reconstruction of the auditory circuits. The application of biomaterials in inner ear cell regeneration offers promising opportunities for the reconstruction of the auditory circuits and the restoration of hearing, yet biomaterials should be strategically explored and combined according to the obstacles to be solved in the inner ear cell regeneration research.

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Section: Superparamagnetic Iron Oxidementioning

confidence: 99%

Current advances in biomaterials for inner ear cell regeneration

Lu,

Wang,

Meng

et al. 2024

Front. Neurosci.

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“…Among all nanoparticles, SPIONs are the most extensively used nanomaterials to increase MSCs homing tendency without affecting their viability, proliferation and differentiation[ 31 , 32 ]. MSCs labeled with SPIONs exhibit enhanced homing due to magnetic attraction[ 50 ]. Several research groups have investigated the homing and tracking of MSCs after being labelled with SPIONs.…”

Section: Mnps To Enhance the Homing Of Transplanted Mscsmentioning

confidence: 99%

Prodigious therapeutic effects of combining mesenchymal stem cells with magnetic nanoparticles

Abu‐El‐Rub¹,

Khasawneh²,

Almahasneh³

2022

WJSC

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Mesenchymal stem cells (MSCs) have gained wide-ranging reputation in the medical research community due to their promising regenerative abilities. MSCs can be isolated from various resources mostly bone marrow, Adipose tissues and Umbilical cord. Huge advances have been achieved in comprehending the possible mechanisms underlying the therapeutic functions of MSCs. Despite the proven role of MSCs in repairing and healing of many disease modalities, many hurdles hinder the transferring of these cells in the clinical settings. Among the most reported problems encountering MSCs therapy in vivo are loss of tracking signal post-transplantation, insufficient migration, homing and engraftment post-infusion, and undesirable differentiation at the site of injury. Magnetic nano particles (MNPs) have been used widely for various biomedical applications. MNPs have a metallic core stabilized by an outer coating material and their ma gnetic properties can be modulated by an external magnetic field. These magnetic properties of MNPs were found to enhance the quality of diagnostic imaging procedures and can be used to create a carrying system for targeted delivery of therapeutic substances mainly drug, genes and stem cells. Several studies highlighted the advantageous outcomes of combining MSCs with MNPs in potentiating their tracking, monitoring, homing, engraftment and differentiation. In this review, we will discuss the role of MNPs in promoting the therapeutic profile of MSCs which may improve the success rate of MSCs transplantation and solve many challenges that delay their clinical applicability.

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“…No adverse effect on hearing was observed after intratympanic injection of ferrocene-loaded nanocarriers into guinea pigs, indicating the possibility of future applications in inner ear theranostics [ 540 ]. Magnetic guidance of IONP-labeled stem cells could increase the number of cells in the target area, and thus most likely improve the therapeutic effect in the treatment of ear damage, e.g., after exposure to ototoxic substances [ 541 ].…”

Section: Other Soft Tissue Regeneration and Engineeringmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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Biodistribution of poly clustered superparamagnetic iron oxide nanoparticle labeled mesenchymal stem cells in aminoglycoside induced ototoxic mouse model

Cited by 10 publications

References 29 publications

Current advances in biomaterials for inner ear cell regeneration

Current advances in biomaterials for inner ear cell regeneration

Prodigious therapeutic effects of combining mesenchymal stem cells with magnetic nanoparticles

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

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