Biodistribution of the radiopharmaceutical sodium pertechnetate after biliopancreatic bypass with a duodenal switch

Araújo‐Filho, Irami; Rêgo, Amália Cínthia Meneses; Brandão-Neto, José; Villarim-Neto, Arthur; Egito, Eryvaldo Sócrates Tabosa do; Azevedo, Ítalo Medeiros; Medeiros, Aldo Cunha

doi:10.1590/s1516-89132007000600024

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…Vegetal extracts and synthetic drugs can generate metabolites capable to promote morphological and/or physiological modifications in treated animals. Several authors have demonstrated that the biodistribution of radiopharmaceuticals may be altered by natural and/or synthetic drugs, diets and surgery 6,8,12,13,14,15 . We have previously shown that the antiparasitic drugs glucantime and mefloquine can alter the biodistribution in vivo of 99m Tc-methylenediphosphonic acid ( 99m Tc-MDP) in Wistar rats 8,12 .…”

Section: Discussionmentioning

confidence: 99%

Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats

et al. 2009

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PURPOSE: Aloe vera is a tropical plant popularly known in Brazil as babosa. We have investigated the effect of aqueous extract of Aloe vera on the biodistribution of Na99mTcO4 and laboratorial parameters in Wistar rats. METHODS: Twelve animals were divided into treated and control groups. In the treated group, Aloe vera was given by gavage (5mg/mL/day) during 10 days. The control group received sorbitol by the same way and period. One hour after the last dose, we injected 0.1mL of Na99mTcO4 by orbital plexus. After 60 min, all the animals were killed. Samples were harvested from the brain, liver, heart, muscle, pancreas, stomach, femur, kidneys, blood, testis and thyroid and the percentage of radioactivity (%ATI/g) was determined. Biochemical dosages were performed. RESULTS: There was a significant increase of %ATI/g in blood, femur, kidneys, liver, stomach, testis and thyroid and also in blood levels of AST and ALT. A significant decrease in levels of glucose, cholesterol, triglycerides, creatinine and urea occurred. The statistical analyses were performed by Mann-Whitney test and T-Student test (p<0.05). CONCLUSION: The aqueous extract of Aloe vera facilitated the uptake of Na99mTcO4 in organs of rats and it was responsible to a high increase of levels of AST and ALT.

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Section: Discussionmentioning

confidence: 99%

Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats

et al. 2009

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“…Several experimental models have been used to evaluate the properties of synthetic and natural drugs [6][7][8] . The biodistribution of radiopharmaceuticals in the animal organism can be changed with concomitant use of drugs natural and/or synthetic, certain diets, parasitic infections, the use of cigarettes and surgery, as demonstrated in studies described by Araújo-Filho et al 15 and Rêgo et al 16 . Changes in biodistribution of sodium pertechnetate (Na 99m TcO 4 ) in organs of rats were observed after treatment with natural products such as Artemisia vulgaris extract 17 and Aloe vera extract 7 .…”

Section: Organsmentioning

confidence: 99%

Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

et al. 2014

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“…The biological behavior of radiopharmaceuticals used for diagnosis in nuclear medicine is well established in the scientific literature. There is evidence that radiopharmaceutical biodistribution may be altered by infectious diseases, procedures, cigarette smoking, surgery, food or natural and synthetic drugs [20][21][22][23][24] . The present study demonstrated that the uptake of Na 99m TcO 4 was not altered…”

Section: Discussionmentioning

confidence: 99%

The malarial infection can alter the normal biodistribution of a radiopharmaceutical?

Holanda

Barbosa²,

Rocha³

et al. 2015

J Surg Clin Res

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Objective: Infection with Plasmodium berghei is a model of murine malaria widely used in experimental studies, similar to Plasmodium falciparum in humans. The aim of this study was to investigate in vivo the influence of P. berghei infection on the biodistribution of sodium pertechnetate (Na 99m TcO 4 ) in mice. Methods: 14 Swiss mice were divided into two groups: control (n=7) and treated (n=7). Treated group were inoculated with 1x10 5 P. berghei infected red blood cells each. On the 15 th day, the infected group and the control group received 0.1 mL (0.66 MBq) of Na 99m TcO 4 . After 40 minutes, all animals were killed and kidney, liver, stomach and blood samples were isolated and the percentage of radioactivity per gram of tissue (%ATI/g) was determined. Parts of tissue samples were used for histological analysis. Data were compared by t-Student test and Mann-Whitney test, considering p<0.05 statistically significant. Results: No statistically significant difference in uptake of ATI%/g was observed in any of the organs. Statistically significant histological changes were seen in the liver of the infected group (cell vacuolization and necrosis) and in the kidney (alterations in the parietal cells and mesangial cells). Conclusions: Although the histopathological finding of necrosis has been a significant result, this change did not alter the uptake of technetium-99m at the site of infection. The parasitic infection by acute malaria or the degree of liver injury probably will not affect the performance of nuclear medicine examinations. The malarial infection can alter the normal biodistribution of a radiopharmaceutical? Holanda, CMC et al J Surg Cl Res -Vol. 5 (2) 2014:69-79 70 RESUMO Objetivo: A infecção por Plasmodium berghei é um modelo murino de malária amplamente utilizado em estudos experimentais, semelhante ao de Plasmodium falciparum nos seres humanos. Este estudo objetivou investigar in vivo a influência da infecção pelo P. berghei na biodistribuição do pertecnetato de sódio (NaTc 99m O 4 ) em camundongos. Métodos: 14 camundongos suiços foram divididos em dois grupos: controle (n=7) e tratado (n=7). O grupo tratado foi inoculado com 1x10 5 hemácias saguineas infectadas por P. Berghei. No 15º dia, o grupo infectado e o grupo controle receberam 0,1 mL (0,66 MBq) de NaTc 99m O 4 . Após 40 minutos, os animais foram sacrificados e amostras de rim, fígado, estômago e sangue foram isolados e a percentagem de radioatividade por grama de tecido (% ATI/g) foi determinada. Amostras dos tecidos foram também utilizadas para análise histológica. Os dados foram comparados pelo teste t de Student e Mann-Whitney, considerando-se p<0,05 estatisticamente significativo. Resultados: não houve diferença estatisticamente significativa na captação do %ATI/g em nenhum dos órgãos estudados. Alterações histológicas estatisticamente significativas foram observadas no fígado do grupo infectado (vacuolização celular e necrose) e no rim (alterações nas células parietais e células mesangiais). Conclusões: Embora o achado histopatológi...

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Biodistribution of the radiopharmaceutical sodium pertechnetate after biliopancreatic bypass with a duodenal switch

Abstract: Study with the purpose to examine the effects of duodenal switch (DS),

Cited by 13 publications

References 43 publications

Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats

Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats

Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

The malarial infection can alter the normal biodistribution of a radiopharmaceutical?

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