Bioelectronics with nanocarbons

Rastogi, Sahil Kumar; Kalmykov, Anna; Johnson, Nicholas; Cohen‐Karni, Tzahi

doi:10.1039/c8tb01600c

Cited by 41 publications

(65 citation statements)

References 180 publications

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“…2, D, II, and E, II) demonstrates how variation of the experimental parameters can precisely control the 3D-SR-BAs’ curvature. This allows direct monitoring of electrical activity of 50- to 200-μm-diameter spheroids, thus improving the biosensor-cell interface while maintaining the spheroids’ integrity ( 16 ).…”

Section: Resultsmentioning

confidence: 99%

“…The patch-clamp technique is limited by its recording sites ( 11 ), and its use in multiplexed recording from spheroids has not been demonstrated. While the microfabricated planar (2D) FETs ( 14 ) and MEAs ( 15 ) allow multiplexed detection on a scale not possible with micropipette technology ( 16 ), both MEAs and FETs are confined to 2D substrates that renders 3D electrical recording immensely challenging (Fig. 1) ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

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Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids

et al. 2019

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Cell-cell communication plays a pivotal role in coordination and function of biological systems. Three-dimensional (3D) spheroids provide venues to explore cellular communication for tissue development and drug discovery, as their 3D architecture mimics native in vivo microenvironments. Cellular electrophysiology is a prevalent signaling paradigm for studying electroactive cells. Currently, electrophysiological studies do not provide direct, multisite, simultaneous investigation of tissues in 3D. In this study, 3D self-rolled biosensor arrays (3D-SR-BAs) of either active field-effect transistors or passive microelectrodes were implemented to interface human cardiac spheroids in 3D. The arrays provided continuous and stable multiplexed recordings of field potentials with high sensitivity and spatiotemporal resolution, supported with simultaneous calcium imaging. Our approach enables electrophysiological investigation and monitoring of the complex signal transduction in 3D cellular assemblies toward an organ-on-an-electronic-chip (organ-on-e-chip) platform for tissue maturation investigations and development of drugs for disease treatment, such as arrhythmias.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids

et al. 2019

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“…Carbon nanotubes (CNTs), hollow 1D nanostructures of rolled-up sheets of graphene, have outstanding physical and chemical characteristics which have made them key-players for photovoltaics [ 146 , 147 ], wearable electronics [ 148 ], drug delivery [ 149 ] and bioelectronics [ 150 ], showing differences and similarities to 2D-based counterparts [ 151 ]. They can be single- or multiwalled CNTs (SWCNTs and MWCNTs, respectively) depending on the number of graphene layers.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

“…CNTs can be synthesized by different approaches, such as arc discharge, laser ablation, and chemical vapour deposition (CVD) [ 152 ]. Importantly CNT synthesis can be compromised by impurities, such as carbonaceous materials and metals, that are removed by washes with acid solutions, and sonication in organic solvents [ 150 ]. Presently, the toxic effects of CNT are not fully understood, being influenced by many parameters, i.e., the amount of exposure, dose, dimensions, and surface functionalization [ 152 ].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

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On the Interaction between 1D Materials and Living Cells

Arrabito

Aleeva

Ferrara

et al. 2020

JFB

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One-dimensional (1D) materials allow for cutting-edge applications in biology, such as single-cell bioelectronics investigations, stimulation of the cellular membrane or the cytosol, cellular capture, tissue regeneration, antibacterial action, traction force investigation, and cellular lysis among others. The extraordinary development of this research field in the last ten years has been promoted by the possibility to engineer new classes of biointerfaces that integrate 1D materials as tools to trigger reconfigurable stimuli/probes at the sub-cellular resolution, mimicking the in vivo protein fibres organization of the extracellular matrix. After a brief overview of the theoretical models relevant for a quantitative description of the 1D material/cell interface, this work offers an unprecedented review of 1D nano- and microscale materials (inorganic, organic, biomolecular) explored so far in this vibrant research field, highlighting their emerging biological applications. The correlation between each 1D material chemistry and the resulting biological response is investigated, allowing to emphasize the advantages and the issues that each class presents. Finally, current challenges and future perspectives are discussed.

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Nanoelectronics for Minimally Invasive Cellular Recordings

Pei

Tian

2019

Adv Funct Materials

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Advances in cellular recordings using engineered devices have greatly increased our understanding in biological systems. These recordings have been an essential part in a broad variety of fields ranging from neuroscience and cardiology to cell biology and have been applied both in research and clinical applications. To provide less tissue damage, reduce foreign-body response, and enhance long-term signal stability, the engineered devices need to be minimally invasive. Pursuing these goals, recently, nanoelectronic probes with improved mechanical, chemical, and biocompatible properties have been developed. Moreover, innovative and automated insertion techniques of neural probes have been reported, further progressing towards a high-bandwidth brain-machine interface system. In this progress report, recent progress in materials, device designs, and implementation techniques aiming for minimally invasive cellular recordings (both in vivo and in vitro) is highlighted, and future directions in these areas are proposed.

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Bioelectronics with nanocarbons

Abstract: Smart bioelectronics fabricated from nanocarbons have the potential to enable seamless integration with electrogenic cells and tissues.

Cited by 41 publications

References 180 publications

Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids

Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids

On the Interaction between 1D Materials and Living Cells

Nanoelectronics for Minimally Invasive Cellular Recordings

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