Bioelimination of histamine in epithelia of the porcine proximal colon of pigs

Aschenbach, Jörg R.; Honscha, K. U.; Vietinghoff, Vivica von; Gäbel, Gotthold

doi:10.1007/s00011-008-8091-9

Cited by 15 publications

(11 citation statements)

References 51 publications

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“…Another possible hypothesis is that the pro- or anti-inflammatory effect of histamine is concentration dependent. However, this possibility seems unlikely in the host since histamine is rapidly degraded by two intestinal enzymes, histamine-N-methyl transferase and diamine oxidase [44]. A more intriguing hypothesis for histamine's anti-inflammatory property is that the effect of histamine is determined by the expression and activation of histamine receptors on the target host cell [45].…”

Section: Discussionmentioning

confidence: 99%

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

et al. 2012

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Beneficial microbes and probiotic species, such as Lactobacillus reuteri, produce biologically active compounds that can modulate host mucosal immunity. Previously, immunomodulatory factors secreted by L. reuteri ATCC PTA 6475 were unknown. A combined metabolomics and bacterial genetics strategy was utilized to identify small compound(s) produced by L. reuteri that were TNF-inhibitory. Hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC) separation isolated TNF-inhibitory compounds, and HILIC-HPLC fraction composition was determined by NMR and mass spectrometry analyses. Histamine was identified and quantified in TNF-inhibitory HILIC-HPLC fractions. Histamine is produced from L-histidine via histidine decarboxylase by some fermentative bacteria including lactobacilli. Targeted mutagenesis of each gene present in the histidine decarboxylase gene cluster in L. reuteri 6475 demonstrated the involvement of histidine decarboxylase pyruvoyl type A (hdcA), histidine/histamine antiporter (hdcP), and hdcB in production of the TNF-inhibitory factor. The mechanism of TNF inhibition by L. reuteri-derived histamine was investigated using Toll-like receptor 2 (TLR2)-activated human monocytoid cells. Bacterial histamine suppressed TNF production via activation of the H2 receptor. Histamine from L. reuteri 6475 stimulated increased levels of cAMP, which inhibited downstream MEK/ERK MAPK signaling via protein kinase A (PKA) and resulted in suppression of TNF production by transcriptional regulation. In summary, a component of the gut microbiome, L. reuteri, is able to convert a dietary component, L-histidine, into an immunoregulatory signal, histamine, which suppresses pro-inflammatory TNF production. The identification of bacterial bioactive metabolites and their corresponding mechanisms of action with respect to immunomodulation may lead to improved anti-inflammatory strategies for chronic immune-mediated diseases.

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Section: Discussionmentioning

confidence: 99%

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

et al. 2012

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“…Histamine released from mast cells and that eliminated from plasma via OCT [27,56] as well as that from food intake may enhance the inflammation level and markedly contribute to severity of IBD [55]. Anti-inflammatory drugs as 5-aminosalicylic acid (5-ASA, mesalazine), corticosteroids, NSAID (non-steroidal anti-inflammatory drugs), immune-suppressor drugs (infliximab, cyclosporine, azathioprine) and antibiotics are currently used for IBD treatment [57].…”

Section: Role Of Histamine In Enteric Dysfunctionsmentioning

confidence: 99%

“…Hypothetical presentation of histamine bioelimination by orally administered DAO and catalase. Histamine from plasma is up taken by enterocytes via OCT (Organic Cationic Transporters) and may be catabolized by vesicular DAO (Diamine Oxidase) and MAO (Monoamine Oxidase) or by HNMT (Histamine Methyl Transferase) to form IA (Imidazole Acetaldehyde), MIAA(1-Methyl-4-ImidazoleAcetic Acid), IAA (Imidazole-4-Acetic Acid), MH (Methyl-Histamine) or is eliminated by enterocyte's tight junction in intestinal lumen with possibility of reabsorption (via OCT) by enterocyte cells for further catabolism[56]. Orally administered DAO may decompose Histamine and the re-uptake is thus prevented.…”

mentioning

confidence: 99%

Plant Histaminase as Bioactive Agent to Lower the Histamine Level: A Mini-Review

Alexandru¹,

Djatougbévi²,

Tchoumi³

et al. 2017

J Gastroenterol Res

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Histamine is a biogenic amine originating endogenously or exogenously from Histidine by enzymatic decarboxylation. Endogenous histamine is mostly generated by basophils and mast cells that, when activated, will release histamine that is involved in various regulatory processes but also will induce multiple allergic effects (hypotension, tachycardia, vascular risks) including anaphylactic shock and possible death. For some histamine related symptoms (itching, asthma, hyperacidity), there are antihistaminic drugs (e.g. Desloratadine-Aerius ® , Loratadine-Claritin ® , Ranitidine-Zantac ®) whereas for anaphylaxis, epinephrine (EpiPen ®) is required. Exogenous histamine, frequently associated to fermented food and beverages, some fruits, fish, may induce a food histaminosis and trigger pseudo-allergic phenomena for which there is no current treatment available. Histamine may also exert some pro-inflammatory effects, particularly damaging for subjects with Inflammatory Bowel Diseases (IBD) as Crohn's Disease (CD) and Ulcerative Colitis (UC), mostly treated with anti-inflammatory drugs. Histamine deleterious effects and those produced as side-effects of antihistaminic drugs (allergic phenomena) or of anti-inflammatory drugs are inconvenient (nausea, diarheea, dizziness). For this reason, novel enzymatic strategies with Diamine Oxidase (DAO, histaminase) to decrease the histamine levels in allergic reactions to food and in ulcerative colitis were recently proposed. This may alleviate the symptoms associated with IBD and food allergens. The therapeutic concept is that histaminase will decrease the level of histamine in the intestine by oxidation, involving the dissolved oxygen. Since the by-product of the DAO reaction is hydrogen peroxide (H 2 O 2), a pro-oxidant agent generating undesirable oxidative damaging effects, a combination of catalase and vegetal histaminase in tablet formulations for oral administration was proposed. Catalase will decompose H 2 O 2 generating in situ more oxygen, promoting thus the decomposition of histamine under histaminase action. Thus, the dual enzymatic histaminase + catalase tablets, could contribute to a healthier intestinal mucosa.This DAO approach seems a non-toxic way to improve the treatment IBD and related inflammatory pathologies.

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“…In contrast to thymus and lymph node, rather large quantities of N-methylhistamineas compared to histamine were found in the intestine . This may indicate a large proportion of secreted histamine in this tissue, most probably produced by tissueresident mast cells and metabolized by histamine N-methyltransferase, which has been reported to be active in the intestine of mice, humans and pigs [25][26][27]. Such relatively high amounts of secreted histamine in the intestine of Balb/c mice may be due to a permanent inflammation of the intestine.…”

Section: Intestinementioning

confidence: 99%

Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c

et al. 2011

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HPLC-mass spectrometry is a useful method for the highly sensitive and simultaneous detection of histamine and N-methylhistamine. Histamine is present in virtually all organs, not only in those traditionally associated with histamine-mediated disease. Highest concentrations are found in stomach, lymph node, and thymus; medium concentrations in heart, spleen, and kidney; and lowest concentrations detected in intestine, brain, liver, and lung.

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Bioelimination of histamine in epithelia of the porcine proximal colon of pigs

Abstract: A basolateral organic cation transporter facilitates histamine secretion into the intestinal lumen and delivers histamine to catabolism by HMT and/or vesicular DAO. Histamine is partially released back into the blood after initial biotransformation to 1-MH.

Cited by 15 publications

References 51 publications

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

Plant Histaminase as Bioactive Agent to Lower the Histamine Level: A Mini-Review

Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c

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