Bioengineered gold nanoparticles using Cynodon dactylon extract and its cytotoxicity and antibacterial activities

Vinayagam, Ramachandran; Santhoshkumar, Murali; Lee, Jun Young; Ernest, David; Kang, Sang Gu

doi:10.1007/s00449-021-02527-5

Cited by 22 publications

(9 citation statements)

References 53 publications

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“…Recently, inorganic NPs have been effectively utilized in nanobactericidal and nanocarrier strategies for treating diseases and delivering drugs, and they can be used against acute microbial diseases and multidrug-resistant bacterial strains [48,49]. Makabenta et al reported that ZnO NPs are the next-generation nanoantibiotics that are most commonly investigated against pathogenic/multidrug-resistant microorganisms [1].…”

Section: Antimicrobial Activity Of Nps Against E Coli and B Cereusmentioning

confidence: 99%

Salicylic-Zinc Nanocomposites with Enhanced Antibacterial Activity

Kang,

Lee,

Singh

et al. 2023

Coatings

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Numerous infectious diseases and microorganisms with high drug resistance have motivated researchers to develop nanocomposite particles as antimicrobial agents. Herein, we report on nanocomposites of salicylic acid (SA) and 5-sulfosalicylic acid (5-SSA) with zinc oxide (ZnO), namely SA-ZnO and 5-SSA-ZnO nanoparticles (NPs), with antibacterial and cytotoxic properties. Ultraviolet-visible and Fourier-transform infrared spectroscopy of the synthesized SA-ZnO and 5-SSA-ZnO NPs indicated the functionalization of ZnO with SA and 5-SSA. X-ray diffraction revealed the crystalline structures of the synthesized NPs. The zeta potentials of the SA-ZnO, 5-SSA-ZnO, and ZnO NPs were 1.42, −5.98, and −0.172, respectively. The SA-ZnO and 5-SSA-ZnO NPs were spherical. Besides, the results of the antimicrobial assay indicated a significant reduction (p < 0.05) in the growth of Escherichia coli and Bacillus cereus by SA-ZnO and 5-SSA-ZnO NPs (0.1%). Scanning electron microscopy of NP-treated bacteria revealed cell death. Moreover, SA-ZnO and 5-SSA-ZnO NPs did not exhibit substantial toxicity against human HaCaT cells even at a high concentration (200 µg/mL). Overall, SA-ZnO and 5-SSA-ZnO NPs exhibited antibiotic-mimicking activity against bacteria with no cytotoxicity.

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Section: Antimicrobial Activity Of Nps Against E Coli and B Cereusmentioning

confidence: 99%

Salicylic-Zinc Nanocomposites with Enhanced Antibacterial Activity

Kang,

Lee,

Singh

et al. 2023

Coatings

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“…The observed results are attributed to the rapid internalization of the synthesized crocin-Au NPs by the cancer cells and the subsequent release of conjugated crocin from the Au NPs. Vinayagam et al [349] green-synthesized Au NPs using Cynodon dactylon (Bermuda grass). The cytotoxic effects of these Au NPs were examined on the MCF-7 breast cancer cell line and the NIH 3T3 noncancerous cell line.…”

Section: Green Au Nps Applications In Cancer Therapy and Diagnosismentioning

confidence: 99%

Green Synthesis of Metal and Metal Oxide Nanoparticles for Recent Applications

Abuzeid,

Julien,

Zhu

et al. 2023

Preprint

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Green synthesis offers a superior alternative to traditional methods for producing metal and metal oxide nanoparticles. This approach is not only benign and safe but also cost-effective, scalable, and straightforward, operating under ambient conditions. Notable metals and metal oxide nanoparticles, such as manganese oxides, iron oxides, silver, and gold, have been produced using various bio-reductants derived from plant extracts. These biological agents not only expedite the reduction process but also stabilize the nanoparticles, serving dual roles as reducing and capping agents. This review presents the green synthesis of nanoparticles (NPs) obtained from biogenic wastes and plant extracts. The green-synthesized nanostructured MnO2 are evaluated as a potential photocatalyst for water treatment and as an electrode material in lithium-ion batteries and supercapacitors. The green-derived iron oxide nanoparticles are examined as promising antioxidant, anti-inflammatory, and anti-diabetic agents. Additionally, this review discusses the green synthesis of precious metal nanoparticles, specifically silver (Ag NPs) and gold (Au NPs), highlighting their potential medical applications in areas like antiviral treatments and cancer therapy.

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“…Upon treating the MCF-7 cancer cells with an IC50 concentration of C.dactylon-AuNPs, the ROS levels increased, leading to programmed cell death. Results of rhodamine staining, AO/EtBr, and DAPI staining show notable mitochondrial membrane damage and DNA fragmentation, suggesting apoptosis in cancer cell lines [ 148 ]. Another study carried out by Uzma and fellow researchers showed the potential of green synthesized AuNPs against breast cancer.…”

Section: Green Synthesis Of Aunps For Cancer Theranosticsmentioning

confidence: 99%

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

et al. 2022

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Nanoparticles are currently used for cancer theranostics in the clinical field. Among nanoparticles, gold nanoparticles (AuNPs) attract much attention due to their usability and high performance in imaging techniques. The wide availability of biological precursors used in plant-based synthesized AuNPs allows for the development of large-scale production in a greener manner. Conventional cancer therapies, such as surgery and chemotherapy, have significant limitations and frequently fail to produce satisfying results. AuNPs have a prolonged circulation time, allow easy modification with ligands detected via cancer cell surface receptors, and increase uptake through receptor-mediated endocytosis. To exploit these unique features, studies have been carried out on the use of AuNPs as contrast agents for X-ray-based imaging techniques (i.e., computed tomography). As nanocarriers, AuNPs synthesized by nontoxic and biocompatible plants to deliver therapeutic biomolecules could be a significant stride forward in the effective treatment of various cancers. Fluorescent-plant-based markers, including AuNPs, fabricated using Medicago sativa, Olax Scandens, H. ambavilla, and H. lanceolatum, have been used in detecting cancers. Moreover, green synthesized AuNPs using various extracts have been applied for the treatment of different types of solid tumors. However, the cytotoxicity of AuNPs primarily depends on their size, surface reactivity, and surface area. In this review, the benefits of plant-based materials in cancer therapy are firstly explained. Then, considering the valuable position of AuNPs in medicine, the application of AuNPs in cancer therapy and detection is highlighted with an emphasis on limitations faced by the application of such NPs in drug delivery platforms.

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Bioengineered gold nanoparticles using Cynodon dactylon extract and its cytotoxicity and antibacterial activities

Cited by 22 publications

References 53 publications

Salicylic-Zinc Nanocomposites with Enhanced Antibacterial Activity

Salicylic-Zinc Nanocomposites with Enhanced Antibacterial Activity

Green Synthesis of Metal and Metal Oxide Nanoparticles for Recent Applications

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

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