Bioevaluation of Anisomeles indica extracts and their inhibitory effects on Helicobacter pylori-mediated inflammation

Lien, H.; Wang, Chyi Yann; Chang, Horng-Jinh; Huang, Chao; Peng, Ming; Sing, Yu Ting; Chen, Chia Chang; Lai, Chih Ho

doi:10.1016/j.jep.2012.11.015

Cited by 21 publications

(13 citation statements)

References 17 publications

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“…The filtrate was evaporated under reduced pressure at a temperature not exceeding 35°C to obtain the crude extract, which was subsequently stored at -20°C until analyzed. The detection and quantification of RV in the extract was performed by using a reversed-phase HPLC method using a Waters e2695 (Waters Separations Module, MI, USA) equipped with a quaternary pump, autosampler, and 2998 photodiode array detector (PDA) [28]. In addition, the Waters Empower software for peak identification and integration was used for the data HPLC data analysis.…”

Section: Methodsmentioning

confidence: 99%

Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems

et al. 2017

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Resveratrol (RV, 3,4ʹ,5-trihydroxystilbene) is naturally produced by a wide variety of plants including grapes and peanuts (Arachis hypogaea). However, the yield of RV from peanut stem and its potential radiosensitizing effects in prostate cancer (PCa) have not been well investigated. In this study, we characterized RV in peanut stem extract (PSE) for the first time and showed that both RV and PSE dose-dependently induced cell death in DOC-2/DAB2 interactive protein (DAB2IP)-deficient PCa cells with the radioresistant phenotype. Furthermore, the combination of radiation with either RV or PSE induced the death of radioresistant PCa cells through delayed repair of radiation-induced DNA double-strand break (DSB) and prolonged G2/M arrest, which induced apoptosis. The administration of RV and PSE effectively enhanced radiation therapy in the shDAB2IP PCa xenograft mouse model. These results demonstrate the promising synergistic effect of RV and PSE combined with radiation in the treatment of radioresistant PCa.

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Section: Methodsmentioning

confidence: 99%

Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems

et al. 2017

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“…Recent studies have suggested that Anisomeles ovata extracts exert various biological activities, including anti-oxidant, anti-inflammatory and tumor cell proliferation inhibitory [7][8][9][10], however, the underlying pharmacological mechanisms are still unclear. In order to identify the active ingredients of Anisomeles ovata, a number of chemical components have been identified, including flavonoids, terpenoids and steroids [9,[11][12][13]. Among the isolated compounds, 5,6,4′-trihydroxy-7,3′-dimethoxyflavone (5-TDMF) was found to be the major flavonoid in the methanol extract of Anisomeles ovata [14].…”

Section: -Tdmf Possesses Weak or No Cytotoxicity Toward The Experimementioning

confidence: 99%

The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

Wang

Liang

et al. 2016

Molecules

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Abstract:The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4 1 -trihydroxy-7,3 1 -dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-κB translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy.

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“…The supernatants from cell cultures were collected, and the levels of keratinocyte-derived chemokines (KCs), IL-6 and TNF-a were determined by using a sandwich ELISA kit (R&D Systems, MN, USA) [32].…”

Section: Measurement Of Cytokinesmentioning

confidence: 99%

Zinc Oxide Nanoparticles Impair Bacterial Clearance by Macrophages

et al. 2014

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Bioevaluation of Anisomeles indica extracts and their inhibitory effects on Helicobacter pylori-mediated inflammation

Cited by 21 publications

References 17 publications

Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems

Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems

The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

Zinc Oxide Nanoparticles Impair Bacterial Clearance by Macrophages

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