Biofabrication for neural tissue engineering applications

Papadimitriou, Lila; Manganas, Phanee; Ranella, Anthi; Stratakis, Emmanuel

doi:10.1016/j.mtbio.2020.100043

Cited by 104 publications

(80 citation statements)

References 214 publications

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“…There are various methods of 3D printing that are used for different types of materials and different tissue engineering approaches [ 94 ]. 3D bioprinting offers the possibility to integrate the cells in a matrix with the potential of supporting the cells during the process of printing [ 95 ]. One of the challenges of 3D bioprinting is the design of proper bioinks with suitable mechanical and biocompatible properties [ 96 ].…”

Section: Fabrication Methods and Platforms For Regenerated Sf-basementioning

confidence: 99%

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

et al. 2021

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Silk refers to a family of natural fibers spun by several species of invertebrates such as spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has been primarily used in the textile industry and in clinical settings as a main component of sutures for tissue repairing and wound ligation. The biocompatibility, remarkable mechanical performance, controllable degradation, and the possibility of producing silk-based materials in several formats, have laid the basic principles that have triggered and extended the use of this material in regenerative medicine. The field of neural soft tissue engineering is not an exception, as it has taken advantage of the properties of silk to promote neuronal growth and nerve guidance. In addition, silk has notable intrinsic properties and the by-products derived from its degradation show anti-inflammatory and antioxidant properties. Finally, this material can be employed for the controlled release of factors and drugs, as well as for the encapsulation and implantation of exogenous stem and progenitor cells with therapeutic capacity. In this article, we review the state of the art on manufacturing methodologies and properties of fiber-based and non-fiber-based formats, as well as the application of silk-based biomaterials to neuroprotect and regenerate the damaged nervous system. We review previous studies that strategically have used silk to enhance therapeutics dealing with highly prevalent central and peripheral disorders such as stroke, Alzheimer’s disease, Parkinson’s disease, and peripheral trauma. Finally, we discuss previous research focused on the modification of this biomaterial, through biofunctionalization techniques and/or the creation of novel composite formulations, that aim to transform silk, beyond its natural performance, into more efficient silk-based-polymers towards the clinical arena of neuroprotection and regeneration in nervous system diseases.

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Section: Fabrication Methods and Platforms For Regenerated Sf-basementioning

confidence: 99%

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

et al. 2021

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“…Tissue engineering is focused on the repair or replacement of damaged or diseased tissues with synthetic and/or natural implants. The conductive scaffolds aimed at regeneration must be biocompatible with the host tissue without inducing inflammatory or immune reactions, allow cellular adhesion and extension, offer proper physical support, and mimic the biological environment, i.e., provide physical properties similar to the native tissue [ 289 , 290 ]. Again, CNTs have been suggested as excellent materials for this purpose.…”

Section: Cnt Embedded With Conjugated Polymersmentioning

confidence: 99%

Carbon Nanomaterials Embedded in Conductive Polymers: A State of the Art

et al. 2021

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Carbon nanomaterials are at the forefront of the newest technologies of the third millennium, and together with conductive polymers, represent a vast area of indispensable knowledge for developing the devices of tomorrow. This review focusses on the most recent advances in the field of conductive nanotechnology, which combines the properties of carbon nanomaterials with conjugated polymers. Hybrid materials resulting from the embedding of carbon nanotubes, carbon dots and graphene derivatives are taken into consideration and fully explored, with discussion of the most recent literature. An introduction into the three most widely used conductive polymers and a final section about the most recent biological results obtained using carbon nanotube hybrids will complete this overview of these innovative and beyond belief materials.

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“…The ideal neural tissue engineering scaffold can mimic the composition and structure of the extracellular matrix (ECM) to facilitate cell seeding, adhesion, proliferation, differentiation, and tissue generation [25,26]. In addition, micro grooves also play a guiding role in the directional growth of nerves, because the correct reconnection of nerve bundles helps to restore nerve function [27].…”

Section: Requirements For Ideal Peripheral Neural Scaffoldsmentioning

confidence: 99%

3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

Zhang

2020

Polymers

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Fabrication of nerve conduits for perfectly repairing or replacing damaged peripheral nerve is an urgent demand worldwide, but it is also a formidable clinical challenge. In the last decade, with the rapid development of manufacture technologies, 3D printing and bioprinting have been becoming remarkable stars in the field of neural engineering. In this review, we explore that the biomaterial inks (hydrogels, thermoplastic, and thermoset polyesters and composite) and bioinks have been selected for 3D printing and bioprinting of peripheral nerve conduits. This review covers 3D manufacturing technologies, including extrusion printing, inkjet printing, stereolithography, and bioprinting with inclusion of cells, bioactive molecules, and drugs. Finally, an outlook on the future directions of 3D printing and 4D printing in customizable nerve therapies is presented.

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Biofabrication for neural tissue engineering applications

Cited by 104 publications

References 214 publications

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

Carbon Nanomaterials Embedded in Conductive Polymers: A State of the Art

3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

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