“…[31][32][33][34] Among other uses, biomaterials are the root of many biomedical and pharma-ceutical preparations, they are fundamental for drug delivery systems from drug-eluting contact lenses to nanocarriers, and are the materials of choice in tissue engineering. [35][36][37][38][39] For instance, biomaterial strategies (implants, nanocarriers, and stimuli-responsive constructs, among others) were found promising in delivering a massive set of drugs\bioactive molecules (e.g., proteins, growth factors, cytokines, genetic materials, and chemotherapy, among others) for the treatment of diverse threatening diseases, 31,[40][41][42][43][44] including retinoblastoma. 22,45,46 Drug delivery systems can modulate the release of therapeutic agents and control their delivery to a specific location in the body.…”