Biofabrication of hybrid bone scaffolds using a dual-nozzle bioplotter and in-vitro study of osteoblast cell

Jiang, Cho‐Pei; Chen, Yo-Yu

doi:10.1007/s12541-014-0549-9

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…Rodil et al reported enhanced biocompatibility via in vitro studies on different carbon-based coatings (a-C, a-C:N and a-C:H) on 316L SS substrates, in which pure a-C film showed particularly better cell viability than the other a-C based coatings [26]. Similarly, several other reports also demonstrated the improved biocompatibility of metal implants after surface modification with carbon-based coatings [27][28][29][30][31]. From a survey of the literature, it was evident that various parameters including the substrate temperature, thickness, chemical composition, roughness, etc., all have significant influences on the mechanical and tribological properties and biocompatibility of a-C coatings.…”

Section: Introductionmentioning

confidence: 94%

Effect of Target Power on Microstructure, Tribological Performance and Biocompatibility of Magnetron Sputtered Amorphous Carbon Coatings

Dhandapani,

Subbiah,

Thangavel

et al. 2023

Materials

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The tribological properties and preosteoblast behavior of an RF magnetron-sputtered amorphous carbon coating on a Si (100) substrate were evaluated. The graphite target power was varied from 200 to 500 W to obtain various coating structures. The amorphous nature of the coatings was confirmed via Raman analysis. The contact angle also increased from 58º to 103º, which confirmed the transformation of the a-C surface from a hydrophilic to hydrophobic nature with an increasing graphite target power. A minimum wear rate of about 4.73 × 10−8 mm3/N*mm was obtained for an a-C coating deposited at a 300 W target power. The 300 W and 400 W target power coatings possessed good tribological properties, and the 500 W coating possessed better cell viability and adhesion on the substrate. The results suggest that the microstructure, wettability, tribological behavior and biocompatibility of the a-C coating were highly dependent on the target power of the graphite. A Finite Element Analysis (FEA) showed a considerable increase in the Von Mises stress as the mesh size decreased. Considering both the cell viability and tribological properties, the 400 W target power coating was identified to have the best tribological property as well as biocompatibility.

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Section: Introductionmentioning

confidence: 94%

Effect of Target Power on Microstructure, Tribological Performance and Biocompatibility of Magnetron Sputtered Amorphous Carbon Coatings

Dhandapani,

Subbiah,

Thangavel

et al. 2023

Materials

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“…Recently, composite materials of polycaprolactone (PCL) were used to fabricate scaffolds by employing FDM, and it was reported that the scaffolds supported cell growth in vitro [189][190][191][192]. Furthermore, Rohner et al [193], reported 14.1% generation of new bone in a pig model after three months, using PCL scaffolds prepared by FDM and coated with bone marrow.…”

Section: Fused Deposition Modeling (Fdm)mentioning

confidence: 99%

Additive Manufacturing Techniques for Fabrication of Bone Scaffolds for Tissue Engineering Applications

Jahani¹,

Wang²,

Brooks³

2020

RPM

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Bone tissue engineering (BTE) as a modern and more effective treatment for bone defects has recently received lots of attention. One of the pivotal parts of BTE is the "scaffold", which functions as an indwelling carrier of cells and additives, as well as, providing a foundation for cell growth and eventually forming new, native-like bone. Up to now, many methods and materials have been employed to manufacture bone scaffolds. This review focuses on providing both basic knowledge of BTE as well as possible methods of scaffold manufacturing. We categorize the fabrication methods into; current conventional methods and newly emerging additive manufacturing (AM) techniques. The fundamental, capabilities and limitations of each technique is investigated, and the latest achievements are presented.

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“…Most additive manufacturing (AM) systems are designed to fabricate parts using a single material, and cannot use multiple materials to construct products. One aspect of AM development is the use of multi-material additive manufacturing (MMAM) technologies to produce parts using different materials [1][2][3]. Table 1 lists MMAM technologies and their associated methods.…”

Section: Introductionmentioning

confidence: 99%

Technical Development of Multi-Resin Three-Dimensional Printer Using Bottom-Up Method

Hsu

Lee²,

Jiang

2018

AUSMT

Self Cite

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The use of multi-resins entails certain challenges due to inter-stain in the intermediate layer of cured resins and misalignment caused by the use of multi-light sources or vat switching. This study proposes a new mechanism for a multi-resin three-dimensional printer that can fabricate physical models consisting of different resins without misalignment using the bottom-up method with a digital projector and a clean modulus that can avoid inter-staining. Experimental results show that the proposed C-arm design offers self-alignment when the platform is switched or during cleaning. The proposed clean modulus can also prevent inter-staining, thus producing a clear boundary layer. The linear and angular dimensions are respectively accurate within 20 µm and 0.2 o .

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Biofabrication of hybrid bone scaffolds using a dual-nozzle bioplotter and in-vitro study of osteoblast cell

Cited by 7 publications

References 18 publications

Effect of Target Power on Microstructure, Tribological Performance and Biocompatibility of Magnetron Sputtered Amorphous Carbon Coatings

Effect of Target Power on Microstructure, Tribological Performance and Biocompatibility of Magnetron Sputtered Amorphous Carbon Coatings

Additive Manufacturing Techniques for Fabrication of Bone Scaffolds for Tissue Engineering Applications

Technical Development of Multi-Resin Three-Dimensional Printer Using Bottom-Up Method

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