Biofilm formation on polyetheretherketone and titanium surfaces

Barkarmo, Sargon; Longhorn, Daniel; Leer, Kiran; Johansson, Carina B.; Stenport, Victoria Franke; Franco-Tabares, Sebastian; Kuehne, Sarah A.; Sammons, Rachel

doi:10.1002/cre2.205

Cited by 46 publications

(30 citation statements)

References 40 publications

(62 reference statements)

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“…They concluded that no significant differences were found between smooth PEEK, machined commercially pure Ti, and Ti 6 Al 4 V and blasted PEEK was characterized by a higher biofilm formation. As highlighted by Barkarmo et al, the influence of superficial topography of the sample after 72 and 120 h is minimal and the significant differences that they found between smooth and blasted PEEK is more probably influenced by other factors, like the different chemical composition of the surfaces [30].…”

Section: Discussionmentioning

confidence: 88%

“…There are only few studies in literature that analyzed biofilm formation on PEEK surfaces. Barkarmo et al, have recently shown results about biofilm formation of different reference strains on PEEK and titanium surfaces at 72 and 120 h [30]. They concluded that no significant differences were found between smooth PEEK, machined commercially pure Ti, and Ti 6 Al 4 V and blasted PEEK was characterized by a higher biofilm formation.…”

Section: Discussionmentioning

confidence: 99%

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Material characterization and Streptococcus oralis adhesion on Polyetheretherketone (PEEK) and titanium surfaces used in implantology

D’Ercole

Cellini

Pilato

et al. 2020

J Mater Sci: Mater Med

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The aim of this study was to evaluate the interaction between Streptococcus oralis and Polyetheretherketone (PEEK), a novel material recently introduced in implantology. The topographical characterization and the Streptococcus oralis adhesion on this material were compared with other titanium surfaces, currently used for the production of dental implants: machined and double etched (DAE). The superficial micro-roughness of the PEEK discs was analyzed by scanning electron microscopy (SEM) and, the Energy Dispersive Spectrometer (EDS) analyzed their chemical composition. Atomic Force Microscopy (AFM) was used to characterize the micro-topography and the sessile method to evaluate the wettability of the samples. Microbiological analysis measured the colony forming units (CFUs), the biomass (OD570 detection) and the cell viability after 24 and 48 h after Streptococcus oralis cultivation on the different discs, that were previously incubated with saliva. Results showed that PEEK was characterized by a micro-roughness that was similar to machined titanium but at nano-level the nano-roughness was significantly higher in respect to the other samples. The EDS showed that PEEK superficial composition was characterized mainly by Carbonium and Oxygen. The hydrophilicity and wetting properties of PEEK were similar to machined titanium; on the contrary, double etched discs (DAE) samples were characterized by significantly higher levels (p < 0.05). PEEK was characterized by significant lower CFUs, biomass and viable cells in respect to the titanium surfaces. No differences were found between machined and DAE. The anti-adhesive and antibacterial properties showed by PEEK at 24 and 48 h against a pioneer such as S. oralis, could have an important role in the prevention of all pathologies connected with biofilm formation, like peri-implantitis in dentistry or prosthetic failures in orthopedics.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Material characterization and Streptococcus oralis adhesion on Polyetheretherketone (PEEK) and titanium surfaces used in implantology

D’Ercole

Cellini

Pilato

et al. 2020

J Mater Sci: Mater Med

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“…Similarly, in antibacterial screens, collection strains are often used, whose virulence and adherence capability might differ from those found in wild-type strains isolated from implants [28,29]. In addition, the promotion of tissue integration is not often tested on antimicrobial screens, and, if it happens to be included, the testing is done separately from the antibacterial properties [30][31][32][33][34]. This is less than ideal as anti-biofilm/antibacterial capability and tissue integration should be preferably tested together.…”

Section: Introductionmentioning

confidence: 99%

Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells

et al. 2020

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Biofilm-mediated infection is a major cause of bone prosthesis failure. The lack of molecules able to act in biofilms has driven research aimed at identifying new anti-biofilm agents via chemical screens. However, to be able to accommodate a large number of compounds, the testing conditions of these screenings end up being typically far from the clinical scenario. In this study, we assess the potential applicability of three previously discovered anti-biofilm compounds to be part of implanted medical devices by testing them on in vitro systems that more closely resemble the clinical scenario. To that end, we used a competition model based on the co-culture of SaOS-2 mammalian cells and Staphylococcus aureus (collection and clinical strains) on a titanium surface, as well as titanium pre-conditioned with high serum protein concentration. Additionally, we studied whether these compounds enhance the previously proven protective effect of pre-incubating titanium with SaOS-2 cells. Out of the three, DHA1 was the one with the highest potential, showing a preventive effect on bacterial adherence in all tested conditions, making it the most promising agent for incorporation into bone implants. This study emphasizes and demonstrates the importance of using meaningful experimental models, where potential antimicrobials ought to be tested for the protection of biomaterials in translational applications.

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“…Randomized controlled clinical trial showed that there is no statistically significant difference between the PEEK pillars compared to titanium and the PEEK did not cause bone resorption or inflammation, showing a promising alternative to titanium support [15]. Regarding the bacterial adhesion, the PEEK showed similar behavior when compared to cp-Ti, and Ti6Al4V [16].…”

Section: Editorialmentioning

confidence: 92%

Polyether Ether Ketone: The High-Performance Polymer in Dentistry

2019

ARC Journal of Dental Science

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The search for a material that presents minor limitations in dentistry has been leading to the need to insert new materials. In this context, a high performance polymer is being investigated and used, the polyether ether ketone (PEEK), which presents promising characteristics as an alternative to titanium dental implants, temporary abutments for dental implant and partial removable prosthesis due to its chemical resistance, mechanical properties, radiolucency, and easily modeled with hand drills or milling cutters.

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Biofilm formation on polyetheretherketone and titanium surfaces

Cited by 46 publications

References 40 publications

Material characterization and Streptococcus oralis adhesion on Polyetheretherketone (PEEK) and titanium surfaces used in implantology

Material characterization and Streptococcus oralis adhesion on Polyetheretherketone (PEEK) and titanium surfaces used in implantology

Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells

Polyether Ether Ketone: The High-Performance Polymer in Dentistry

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