2020
DOI: 10.34133/2020/9426453
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Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections

Abstract: The formation of bacterial biofilms closely associates with infectious diseases. Until now, precise diagnosis and effective treatment of bacterial biofilm infections are still in great need. Herein, a novel multifunctional theranostic nanoplatform based on MnO2 nanosheets (MnO2 NSs) has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy (aPDT) of bacterial biofilm infections. In this study, Mn… Show more

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Cited by 94 publications
(77 citation statements)
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“…Although the development of antibiotics has relieved the unfavorable condition to a considerable extent, we have not conquered bacterial infections fundamentally, especially in the situation where the bacteria have the staggering capability of mutation to adapt to extremely harsh environments resulting in the transformation to antibiotic-resistant bacteria. Additionally, many bacteria live in a sticky and multicellular community called biofilm which consists of plentiful biochemical molecules making an indispensable contribution to bacterial growth and reproduction [ 51 ]. The biofilms serve as a natural obstacle to prevent the invasion of life-threatening substances including antibiotics and some designed antibacterial nanomaterials.…”
Section: Applications Of Low-temperature Pttmentioning
confidence: 99%
“…Although the development of antibiotics has relieved the unfavorable condition to a considerable extent, we have not conquered bacterial infections fundamentally, especially in the situation where the bacteria have the staggering capability of mutation to adapt to extremely harsh environments resulting in the transformation to antibiotic-resistant bacteria. Additionally, many bacteria live in a sticky and multicellular community called biofilm which consists of plentiful biochemical molecules making an indispensable contribution to bacterial growth and reproduction [ 51 ]. The biofilms serve as a natural obstacle to prevent the invasion of life-threatening substances including antibiotics and some designed antibacterial nanomaterials.…”
Section: Applications Of Low-temperature Pttmentioning
confidence: 99%
“…Xiu et al designed MnO 2 ‐based theranostic nanoagents for simultaneous detection and therapy of biofilm infections in vivo 110 . In this work, MnO 2 NSs were modified with bovine serum albumin (BSA), PEG, and Ce6 to form MnO 2 ‐BSA/PEG‐Ce6 nanosheets (MBP‐Ce6 NSs, Figure 8A).…”
Section: Promising Antibiofilm Strategymentioning
confidence: 99%
“…(D) MR images and (E) MR signal intensity of the infected tissues after treatment. (F) Immunofluorescence analysis and (G) photographs of the infected tissues after treatment 110 . Copyright 2020, American Association for the Advancement of Science.…”
Section: Promising Antibiofilm Strategymentioning
confidence: 99%
“…Precise drug delivery can be achieved through stimuli-responsive NPs. As a result of the combined activities of bacterial metabolism and host immune response, acidification can occur at the infected sites when hosts were infected by bacteria [ 218 , 219 ]. The efficacy of the delivery and release of drugs can be significantly hindered by the acid environment.…”
Section: Nanotechnology In Combatting Amrmentioning
confidence: 99%