Biofilm Targeting Strategy in the Eradication of Burkholderia Infections: A Mini-Review

Gunardi, Wani Devita; Timotius, Kris Herawan; Natasha, Agustine; Evriarti, Paulina R.

doi:10.2174/1874285802115010051

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…The approach that should be developed is the other biofilm therapy target, such as QS inhibition, adhesioninhibiting-type bacteria, anti-virulence factor, and exopolysaccharide matrix degradation, to overcome antibiotic resistance. [26][27][28]…”

Section: Discussionmentioning

confidence: 99%

Antibiotic effectiveness on biofilm-producing Escherichia coli isolated from catheterized patients

Gunardi

Dharmawan²,

Layanto³

2022

JMedScie

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Biofilm is one of the factors that facilitate the occurrence of catheter-associated urinary tract infection (CAUTI). Escherichia coli is reported as one of the most dominant bacteria that have virulence factors including biofilm formation. Uropathogenic E. coli (UPEC) shows increasing resistance to several antibiotics. Examination of the antibiotic sensitivity on the biofilm-producing E. coli and its activity on biofilm formation are important for selecting high effectiveness antibiotics which is beneficial for the management of CAUTI patients. A total of 35 E. coli isolates were recultured in the medium of LB agar and blood agar. The isolates were evaluated the sensitivity based on their MIC value to several antibiotics. In addition, the antibiofilm activity of the antibiotics based on their MBIC value was also evaluated. The data obtained were analyzed both descriptively and analytically. Almost the E. coli isolates have good sensitivity to meropenem antibiotics, amoxicillin-clavulanic acid, and Fosfomycin. However, among the evaluated antibiotics, only fosfomycin that showed antibiofilm activity. The different in terms of the resistance phenotype between the urinary isolates and the catheter isolates was observed. However, there were no significantly differences in the MIC value (pMIC=0.522) and the MBIC value (pMBIC = 0.523). In conclusion, the alternatives of antibiotic therapy for the planktonic bacteria are amoxicillin-clavulanic acid and fosfomycin, while for the biofilm bacteria is fosfomycin. A biofilm screening examination on the catheter to improve the effectiveness of therapy management for CAUTI patients is recommended.

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Section: Discussionmentioning

confidence: 99%

Antibiotic effectiveness on biofilm-producing Escherichia coli isolated from catheterized patients

Gunardi

Dharmawan²,

Layanto³

2022

JMedScie

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Novel biostimulant bacterial exopolysaccharides production via solid-state fermentation as a valorisation strategy for agri-food waste

Garcia-Muchart,

Martínez-Avila,

Mejias

et al. 2024

Environ Sci Pollut Res

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Bacterial exopolysaccharides (EPS) are extracellular polymer-based substances recently defined as potential plant biostimulants, as they can increase nutrient uptake, water retention, and resistance to abiotic stress. As sugar-based substances, the bacteria producing them need to grow in a sugar-rich substrate. Hence, some agri-food by-products could be used as suitable carbon sources for EPS production as a cost-effective and more sustainable alternative to conventional substrates. Thus, this study aimed to produce EPS from specific bacterial strains through solid-state fermentation (SSF) using agri-food waste as a low-cost substrate. Six residues and five bacterial strains were tested in a lab-scale SSF system. From the assessed substrate-strain combinations, Burkholderia cepacia with ginger juice waste (GJW) resulted in the most promising considering several process parameters (EPS production, cumulative oxygen consumption, biomass growth, reducing sugars consumption). Also, dynamic monitoring of the system allowed for establishing 5 days as a suitable fermentation time. Then, using response surface methodology (Box-Behnken design), the process was optimised based on airflow rate (AF), inoculum size (IS), and micronutrient concentration (MN). In this stage, the best conditions found were at 0.049 (± 0.014) L h−1 per gram of dry matter (DM) for AF, 8.4 (± 0.9) E + 09 CFU g−1 DM for IS, and 0.07 (± 0.01) mL g−1 DM for MN, reaching up to 71.1 (± 3.2) mg crude EPS g−1 DM. Results show the potential of this approach to provide a new perspective on the value chain for the agri-food industry by introducing it to a circular economy framework.

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Bactericidal and antibiofilm activities of Piper betle extract against Burkholderia pseudomallei : in vitro and in silico approaches

Eawsakul,

Klangbud,

Saengsawang

et al. 2024

Biofouling

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Biofilm Targeting Strategy in the Eradication of Burkholderia Infections: A Mini-Review

Cited by 3 publications

References 65 publications

Antibiotic effectiveness on biofilm-producing Escherichia coli isolated from catheterized patients

Antibiotic effectiveness on biofilm-producing Escherichia coli isolated from catheterized patients

Novel biostimulant bacterial exopolysaccharides production via solid-state fermentation as a valorisation strategy for agri-food waste

Bactericidal and antibiofilm activities of Piper betle extract against Burkholderia pseudomallei : in vitro and in silico approaches

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