Biofilme em rinossinusite crônica com polipose nasossinusal: estudo piloto

Bezerra, Thiago Freire Pinto; Pádua, Francini Grecco de Melo; Ogawa, Allex Itar; Gebrim, Eloísa Maria Mello Santiago; Saldiva, Paulo Hilário Nascimento; Voegels, Richard Louis

doi:10.1590/s1808-86942009000600003

Cited by 44 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Além disso, a higiene nasal diária com soro fisiológico é uma prática recomendada para manter as vias aéreas superiores desobstruídas de agentes irritantes, enquanto a identificação e evitação de desencadeadores, como alérgenos e irritantes ambientais, são estratégias cruciais para controlar os sintomas (Ito et al 2019 na redução de pólipos nasais e sintomas associados. Além disso, a terapia fotodinâmica, investigada como uma alternativa terapêutica, revela benefícios na redução da inflamação e dos sintomas nasais, proporcionando mais uma opção para os pacientes (Bezerra et al 2021;Santa et al 2022).…”

Section: Resultsunclassified

Tratamento da Rinossinusite Crônica: Atualizações e Desafios

Marambaia,

Gonçalves,

Barros

et al. 2024

Braz. J. Implantol. Health Sci.

View full text Add to dashboard Cite

A rinossinusite crônica, caracterizada pela inflamação persistente das cavidades nasais e seios paranasais, pode ser subdividida em RCP e RCSP. Seu diagnóstico e tratamento multifatorial exigem uma abordagem abrangente, incluindo exames físicos, terapias farmacológicas e intervenções cirúrgicas, quando necessário. Objetivo: Assim, o objetivo do presente estudo é analisar os avanços e desafios acerca do tratamento da rinossinusite crônica. Metodologia: A revisão multidisciplinar sobre o tratamento da rinossinusite crônica utilizou bases de dados como PubMed, LILACS e SciELO, selecionando estudos dos últimos 5 anos. Critérios rigorosos de inclusão e exclusão foram aplicados para analisar desafios e avanços, proporcionando uma visão atualizada da literatura sobre o tema. Resultados e Discussão: A rinossinusite crônica exige uma abordagem multifacetada, integrando métodos farmacológicos e não medicamentosos, como a lavagem nasal e a terapia com corticosteroides. No entanto, avanços terapêuticos, como a terapia biológica e a fotodinâmica, oferecem novas perspectivas; contudo, desafios como diagnóstico preciso e resistência bacteriana persistem, demandando pesquisa contínua. Conclusão: Os avanços na rinossinusite crônica prometem melhorar a qualidade de vida dos pacientes; no entanto, é essencial investir em pesquisa contínua, ensaios clínicos e colaboração multidisciplinar para desenvolver terapias mais eficazes e abordar desafios persistentes

show abstract

Section: Resultsunclassified

Tratamento da Rinossinusite Crônica: Atualizações e Desafios

Marambaia,

Gonçalves,

Barros

et al. 2024

Braz. J. Implantol. Health Sci.

View full text Add to dashboard Cite

show abstract

Effects of povidone‐iodine composite on the elimination of bacterial biofilm

Jeronimo

Choi

Yeon

et al. 2020

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

BackgroundPovidone‐iodine (PVP‐I) is well known as an antiseptic and exhibits extensive activity against various pathogens. However, due to its uniquely unpleasant nature, it cannot be used locally to deactivate various sinonasal pathogens. Therefore, we developed a PVP‐I composite that blocks the unpleasant odor of PVP‐I for use as a local antiseptic in the sinonasal cavity and evaluated its effect on bacterial biofilm's formation and elimination in in vivo and in vitro models.MethodsMTT, lactate dehydrogenase, and live/dead staining assay were performed to examine the cellular toxicity of PVP‐I composites on the primary human nasal epithelial and RPMI 2650 cells. Crystal violet assay was performed to quantify bacterial biofilm after treating with various agents, including PVP‐I and antibiotics. Hematoxylin‐and‐eosin staining, live/dead staining assay, and scanning electron microscopy were conducted to evaluate the effect of PVP‐I on biofilm formation in a mice biofilm model.ResultsIt was observed that the PVP‐I composite did not have any significant toxic effect on the nasal epithelial cells. Furthermore, the PVP‐I composite effectively inhibited the formation of bacterial biomass within a dose‐dependent manner after 48 hours of incubation with Pseudomonas aeruginosa and Staphylococcus aureus. In mice, it effectively eliminated biofilm from the mucosa of the nasal cavity and maxillary sinus at the tested concentrations.ConclusionThe results of this study indicate that the PVP‐I composite is a promising compound that could be used locally to prevent the formation of biofilms and to eliminate them from the sinonasal cavity.

show abstract

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Han

Wang

Sun

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The purpose of this study was to investigate the incidence of bacterial biofilm (BBF) in patients with chronic rhinosinusitis (CRS) using confocal scanning laser microscopy (CSLM), and to assess the relationship between BBF and clinical features of CRS. This was a prospective observational study of the sinus mucosa of 27 CRS patients and 10 controls undergoing endoscopic sinus surgery (ESS). Clinical information was recorded preoperatively and sinus mucosal specimens were collected intraoperatively. We determined the existence of BBF with BacLight/CSLM detection, and proposed a BBF scoring system based on its morphologic features. Clinical parameters, including symptom score, endoscopy score, CT score and symptom duration, were compared between CRS patients with and without BBF, and among CRS patients with different BBF score. BBF was found in 16/27 (59.26%) CRS patients and none in 10 controls. SNOT-20 symptom score and individual symptoms including need to blow nose, cough and postnasal discharge were significantly more severe in CRS patients with BBF than those without. BBF score was better correlated than BBF existence with SNOT-20 score (r = 0.811, P < 0.001 vs. r = 0.604, P = 0.001), and correlated with both endoscopy score (r = 0.490, P = 0.009) and symptom duration (r = 0.487, P = 0.010), neither was correlated with BBF (P = 0.824; P = 0.263). BBF score is likely to guide anti-BBF therapy in CRS patients.

show abstract

Biofilme em rinossinusite crônica com polipose nasossinusal: estudo piloto

Cited by 44 publications

References 29 publications

Tratamento da Rinossinusite Crônica: Atualizações e Desafios

Tratamento da Rinossinusite Crônica: Atualizações e Desafios

Effects of povidone‐iodine composite on the elimination of bacterial biofilm

Relationship between bacterial biofilm and clinical features of patients with chronic rhinosinusitis

Contact Info

Product

Resources

About